oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2018-17-1-19-25oncotomsk-666Research ArticleЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯLABORATORY AND EXPERIMENTAL STUDIESМАГНИТНЫЕ НАНОЧАСТИЦЫ Cu/Fe С ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮCu/Fe MAGNETIC NANOPARTICLES WITH ANTITUMOR ACTIVITYБакинаО. В.BakinaO. V.

Бакина Ольга Владимировна - кандидат химических наук, научный сотрудник, SPIN-код: 9002-1344.

634055, Томск, пр. Академический, 2/4

Olga V. Bakina - PhD, Researcher, SPIN-code: 9002-1344.

2/4, pr. Akademichesky, 634021-Tomsk

ovbakina@ispms.tsc.ruГлазковаЕ. А.GlazkovaE. A.

Глазкова Елена Алексеевна - кандидат технических наук, старший научный сотрудник, SPIN-код: 9642-1860.

Elena А. Glazkova - PhD, Senior Researcher, SPIN-code: 9642-1860.

2/4, pr. Akademichesky, 634021-Tomsk

eagl@ispms.tsc.ruСваровскаяН. В.SvarovskayaN. V.

Сваровская Наталья Валентиновна - кандидат химических наук, старший научный сотрудник, SPIN-код: 3019-7455.

Natalia V. Svarovskaya - PhD, Senior Researcher, SPIN-code: 3019-7455.

2/4, pr. Akademichesky, 634021-Tomsk

nvsv@ispms.tsc.ruКоровинМ. С.KorovinM. S.

Коровин Матвей Сергеевич - кандидат медицинских наук, научный сотрудник.

634055, Томск, пр. Академический, 2/4; 634050, Томск, Московский тракт, 2

Matvey S. Korovin - MD, PhD, Researcher.

2/4, pr. Akademichesky, 634021-Tomsk; 2, Moskovsky trakt, 634050-Tomsk

msk@ispms.tsc.ruФоменкоА. Н.FomenkoA. N.

Фоменко Алла Николаевна - инженер, SPIN-код: 4435-8053.

634055, Томск, пр. Академический, 2/4; 634050, Томск, Московский тракт, 2

Alla N. Fomenko - Engineer, SPIN-code: 4435-8053.

2/4, pr. Akademichesky, 634021-Tomsk; 2, Moskovsky trakt, 634050-Tomsk

alserova@ispms.tsc.ruЛернерМ. И.LernerM. I.

Лернер Марат Израильевич - доктор технических наук, заведующий лабораторией, SPIN-код: 3247-9864.

Marat I. Lerner - DSc, Head of Laboratory, SPIN-code: 3247-9864.

2/4, pr. Akademichesky, 634021-Tomsk

lerner@ispms.tsc.ruАвгустиновичА. В.AvgustinovichА. V.

Августинович Александра Владимировна, кандидат медицинских наук, заведующая отделением, SPIN-код: 2952-6119.

Alexandra V. Avgustinovich - MD, PhD, Head of Department, SPIN-code: 2952-6119.

3, Morskoy Prospekt, 197110-Saint-Petersburg

aov862@yandex.ruИнститут физики прочности и материаловедения Сибирского отделения Российской академии наукРоссияInstitute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of SciencesRussian FederationИнститут физики прочности и материаловедения Сибирского отделения Российской академии наук (ИФПМ СО РАН); Сибирский государственный медицинский университетРоссияInstitute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of SciencesRussian FederationКонсультативно-диагностический центр с поликлиникой Управления делами Президента Российской ФедерацииРоссияClinical Diagnostic Medical CentreRussian Federation2018030320181711925Copyright © Бакина О.В., Глазкова Е.А., Сваровская Н.В., Коровин М.С., Фоменко А.Н., Лернер М.И., Августинович А.В., 20182018Бакина О.В., Глазкова Е.А., Сваровская Н.В., Коровин М.С., Фоменко А.Н., Лернер М.И., Августинович А.В.Bakina O.V., Glazkova E.A., Svarovskaya N.V., Korovin M.S., Fomenko A.N., Lerner M.I., Avgustinovich А.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/666

Применение биметаллических наночастиц биосовместимых металлов с магнитными свойствами является новым подходом для борьбы с опухолевыми клетками. Наночастицы из несмешивающихся металлов Fe/Cu с разделенными фазами на уровне одной частицы синтезировали методом электрического взрыва железной и медной проволок в атмосфере аргона. Для характеристики наночастиц Cu/Fe использовали рентгено-фазовый анализ, просвечивающую электронную микроскопию, термодесорбцию азота и энергодисперсионный анализ. Наши исследования показали, что синтезированные наночастицы обладают противоопухолевой активностью по отношению к клеткам линий Neuro 2A и J 774. Такие частицы могут быть перспективны для создания препаратов для магнитной целевой доставки.

The use of bimetallic nanoparticles of biocompatible metals with magnetic properties is a new approach to combating cancer cells. Nanoparticles of immiscible Fe/Cu metals, with separated phases at the level of one particle, were synthesized by electric explosion of iron and copper wires in an argon atmosphere. To characterize Cu/Fe nanoparticles, X-ray phase analysis, transmission electron microscopy, thermal desorption of nitrogen, and energy-dispersive analysis were used. Our research has shown that synthesized nanoparticles have antitumor activity against Neuro 2A and J 774 cell lines. Such particles may be promising for the development of drugs for magnetic target delivery.

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The authors declare that there are no conflicts of interest present.