oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2018-17-1-72-81oncotomsk-674Research ArticleОБЗОРЫREVIEWSВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ХОЛОДНОЙ АТМОСФЕРНОЙ ПЛАЗМЫ В ОНКОЛОГИИ (ОБЗОР ЛИТЕРАТУРЫ)FEASIBILITY OF USING COLD ATMOSPHERIC PLASMA IN THE TREATMENT OF CANCER PATIENTS (LITERATURE REVIEW)КороткийВ. Н.KorotkyV. N.

Короткий Владимир Николаевич - кандидат медицинских наук, доцент кафедры дерматовенерологии.

117997, Москва, ул. Островитянова, 1

Vladimir N. Korotky, MD, PhD, Department of Dermatology and Venerology.

vkbknk@gmail.comФГБУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical CenterRussian Federation2018040320181717281Copyright © Короткий В.Н., 20182018Короткий В.Н.Korotky V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/674

Лучевая и фотодинамическая терапия, используемые при противоопухолевом лечении, генерируют только активные формы кислорода. Вместе с тем было показано, что высокие концентрации NO индуцируют апоптоз опухолевых клеток, предполагая, что азотзависимый стресс может быть одним из решающих факторов в противоопухолевой терапии. Холодная атмосферная плазма (CAP) представляет собой высокореактивное ионизированное физическое состояние, которое вызывает различные биологические эффекты. Процессы ионизации, диссоциации, возбуждения и рекомбинации атомов и молекул в низкотемпературной плазме (НТП) приводят к образованию большого количества активных форм кислорода и азота. В обзоре представлены результаты исследований, раскрывающих механизм противоопухолевого действия НТП, ее воздействие на различные клеточные линии опухолей, описаны результаты лечения опухолей на моделях животных. Высказываются предложения по применению НТП в терапии злокачественных новообразований.

Radiation and photodynamic therapy used in anti-cancer therapy generate only active forms of oxygen. High NO concentrations has been shown to induce apoptosis of tumor cells, suggesting that nitrogen-dependent stress can be one of the decisive factors in anti-cancer therapy. Cold atmospheric plasma (CAP) is a highly reactive ionized physical state that causes various biological effects. The processes of ionization, dissociation, excitation and recombination of atoms and molecules in CAP lead to the formation of a large number of active forms of oxygen and nitrogen. This review presents the results of studies revealing the mechanism of the antitumor effect of CAP, its effect on various tumor cell lines, and the treatment outcomes in animal models. Further studies on using CAP in cancer therapy are required.

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The authors declare that there are no conflicts of interest present.