EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS
https://doi.org/10.21294/1814-4861-2020-19-6-93-98
Abstract
The purpose of the study was to analyze the antitumor effects of the extract of mycelium from Duddingtonia flagrans (strain F-882) on xenografts of human C33a cervical cancer cells.
Material and Methods. To evaluate the antitumor effect, we used the absolute values of xenograft volumes and calculated the tumor growth inhibition and the index of tumor growth.
Results. At the first stage of the experiment, a 4-week subcutaneous injection of the water extract of F-882 resulted in an almost twofold slowdown in xenograft growth, with the tumor growth inhibition value of 50.6 %. In the second stage of the experiment, a 2.5-week subcutaneous injection followed by a 1.5-week intratumoral injection of F-882 also caused the tumor growth inhibition. After completing F-882 injections, the effect of tumor growth inhibition continued for 2.5 weeks and the tumor growth inhibition value was 58.7 %.
Conclusion. The mycelium extract F-882 was shown to have an antitumor effect on subcutaneous xenografts of human C33a cervical carcinoma cells.
Supporting agencies: The studies are supported by the budget project (№ 0324-2019-0041) and implemented using the equipment of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS, supported by the Ministry of Education and Science of Russia (Unique identifier of the project RFMEFI62119X0023)
About the Authors
O. I. Solovieva
Federal Research Center of Cytology and Genetics SB RAS
Russian Federation
Russian Federation
Laboratory Assistant at the SPF-Vivarium
10, ak. lavrentiev ave., 630090, Novosibirsk, Russia
E. L. Zavjalov
Federal Research Center of Cytology and Genetics SB RAS
Russian Federation
Russian Federation
PhD, Head of the SPF-Vivarium
Researcher ID (WOS): X-2415-2019. Author ID (Scopus): 26321256500
10, ak. lavrentiev ave., 630090, Novosibirsk, Russia
T. V. Teplyakova
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
DSc, Professor, Head of the Mycology Laboratory
630559, Koltsovo, Russia
L. R. Lebedev
State Research Center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
MD, DSc, Head of the Laboratory of Nucleic Acids and Recombinant Proteins of the State Research Center
630559, Koltsovo, Russia
i A. Razumov
Federal Research Center Institute of Cytology and Genetics, Siberian Division
of the Russian Academy of Sciences;
State Research center of Virology and Biotechnology «Vector»
Russian Federation
Russian Federation
DSc, Senior Researcher at the Laboratory of Laboratory Animal Genetics
Researcher ID (WOS): X-1783-2019. Author ID (Scopus): 7003465369
10, ak. lavrentiev ave., 630090, Novosibirsk, Russia
630559, Koltsovo, Russia
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Review
For citations:
Solovieva O.I., Zavjalov E.L., Teplyakova T.V., Lebedev L.R., Razumov i.A. EFFECT OF THE MYCELIUM EXTRACT FROM DUDDINGTONIA FLAGRANS FUNGUS ON SUBCUTANEOUS XENOGRAFT OF HUMAN C33a CERVICAL CARCINOMA CELLS. Siberian journal of oncology. 2020;19(6):93-98. (In Russ.) https://doi.org/10.21294/1814-4861-2020-19-6-93-98
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