ADAPTATION OF LINEAR-QUADRATIC MODEL FOR PLANNING NEUTRON THERAPY REGIMENS
Abstract
Based on the fact that the parameters of the linear-quadratic model for neutron therapy were found, the comparison of single therapeutic doses in neutron therapy, calculated using the TDF (time-dose-fractionation) and linear-quadratic (LQ) models were carried out. The calculation results were shown to be in good agreement. We also compared the degree of discrepancy in results calculated using the TDF and LQ models between neutron therapy and gamma therapy. It was shown that the use of the linear-quadratic model designed for neutron therapy is capable of providing adequate control for radiation-induced tissue reactions.
About the Authors
V. A. Lisin
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
V. V. Velikaya
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
I. A. Miloichikova
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
References
1. Guter R.S., Ovchinskiy B.V. Elements of numerical analysis and mathematical processing of the experimental results. M.: Nauka, 1970. 430 p. [in Russian]
2. Zholkiver K.I., Zevrieva I.F., Dosakhanov A.Kh. Quantitative assessment of the biological radiation effect in normal tissues of cancer patients. Alma-Ata,1983. 36 p. [in Russian]
3. Lisin V.A. TDF model for cancer therapy with fast neutrons // Meditsinskaya radiologiya. 1988. № 9. P. 9–12. [in Russian]
4. Lisin V.A. Assessment of parameters of linear-quadratic model in neutron therapy // Meditsinskaya fizika. 2010. № 4. P. 5–12. [in Russian]
5. Lisin V.A. Theoretical studies of dose-dependence of fast neutron RBE for skin and normal tissue // Radiobiologiya.1986. № 5. P. 656–660. [in Russian]
6. Lisin V.A., Musabaeva L.I. Quantitative assessment of radiationinduced reactions considering radiobiological parameters // Med. radiologiya. 1983. № 12. P. 30–34. [in Russian]
7. Neutron therapy for cancer / Eds. L.I. Musabaeva, V.A. Lisin. Tomsk, 2008. 285 p. [in Russian]
8. Novikov V.A., Musabaeva L.I., Kitsmanyuk Z.D., Lisin V.A. Tumors of the nasal cavity and paranasal sinuses (new approaches to treatment and rehabilitation). Tomsk, 2002. 197 p. [in Russian]
9. Mechanisms of densely ionizing radiation / Eds. A.V. Savich, V.K. Mazurik. M.: Meditsina, 1985. 230 p. [in Russian]
10. Pavlov A.S., Fadeeva M.A., Karyakina N.F. Linear-quadratic model in calculations of isoeffective dose and in the assessment of anti-tumor effect and radiation-induced complications: A guide for physicians. M., 2005. 67 p. [in Russian]
11. Yarmonenko S.P. Radiobiology of humans and animals. M.: Vysshaya shkola, 1984. 375 p. [in Russian]
12. Сatterall M., Bewley D.K. Fast neutrons in the Treatment of Cancer. London, Academic Press, New York, Grune and Stratto. 1979. 394 p.
13. Dale R.G., Jones B. The assessment of RBE effects using the concept of biologically effective dose // Int. J. Radiat. Oncol. Biol. Phys. 1999. Vol. 43 (3). P. 639–645.
14. Yaes R.J. Linear-quadratic model isoeffect relations for proliferating tumor cells for treatment with multiple fractions per day // Int. J. Radiat. Oncol. Biol. Phys. 1989. Vol. 17 (4). P. 901–905.
Review
For citations:
Lisin V.A., Velikaya V.V., Miloichikova I.A. ADAPTATION OF LINEAR-QUADRATIC MODEL FOR PLANNING NEUTRON THERAPY REGIMENS. Siberian journal of oncology. 2015;1(1):33-37. (In Russ.)
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