COMPLICATIONS OF NEOADYAVANT THERAPY FOR CANCER OF THE HEAD OF THE PANCREAS
https://doi.org/10.21294/1814-4861-2019-18-3-20-25
Abstract
Aim: to study complications of preoperative chemoembolization of the gastroduodenal artery and external beam radiation therapy in patients with pancreatic head cancer.
Material and Methods. Sixty patients underwent chemoembolization of the gastroduodenal artery and external beam radiation therapy. Femoral artery angiography was performed using the Seldinger’s technique. Lipiodol 5–7 ml and gemcitabine 400 mg/m2 were used for transarterial chemoembolization. Radiation therapy was given at a total dose of 50 Gy (2 Gy/fraction, 5 times a week, over 5 weeks) using AGAT -R apparatus.
Results. Complications after chemoembolization of the gastroduodenal artery were observed in 18.3 % of patients: abdominal pain in 3.3 % of patients; pain and nausea in 3.3 %; pain, nausea and fever in 6.7 %; pain, nausea and increased blood amylase in 1.7 %; pain, nausea and fever, blood amylase in 1.7 %; nausea, fever and blood amylase in 1.7 %. Radiation-induced injuries were observed in 23.3 % of patients: erythema in 18.3 %, grade 1 leukopenia in 1.7% and grade 2 leukopenia in 3.3 %.
Conclusion. Complications of neoadjuvant therapy in terms of frequency and severity were consistent with literature data, were manageable with conservative treatment, and did not increase the duration of the preoperative period.
About the Authors
R. I. Rasulov
Irkutsk State Medical Academy of Postgraduate Education;
Irkutsk Regional Oncology Center
Russian Federation
Russian Federation
Rodion I. Rasulov, MD, DSc, Professor of the Department of Oncology, Irkutsk State Medical Academy of Postgraduate Education
100, Yubileiny Street, 664049-Irkutsk,
32, Frunze Street, 664035-Irkutsk
M. V. Zemko
Irkutsk Regional Oncology Center
Russian Federation
Russian Federation
Marina V. Zemko, Postgraduate, Department of Oncology, Irkutsk State Medical Academy of Postgraduate Education
32, Frunze Street, 664035-Irkutsk
A. V. Shelekhov
Irkutsk State Medical Academy of Postgraduate Education;
Irkutsk Regional Oncology Center;
Irkutsk State Medical University
Russian Federation
Russian Federation
Alexey V. Shelekhov, MD, DSc, Professor of the Department of Oncology, Irkutsk State Medical Academy of Postgraduate Education
100, Yubileiny Street, 664049-Irkutsk,
32, Frunze Street, 664035-Irkutsk,
1, Krasnogo Vosstaniya Street, 664003-Irkutsk
K. G. Zubrinckiy
Irkutsk Regional Oncology Center
Russian Federation
Russian Federation
Konstantin G. Zubrinsky, Assistant of the Department of Oncology of Irkutsk State Medical Academy of Postgraduate Education
32, Frunze Street, 664035-Irkutsk
G. I. Songolov
Irkutsk State Medical University
Russian Federation
Russian Federation
Gennady I. Songolov, MD, PhD, Associate Professor of the Department of Topographic Anatomy and Surgery
1, Krasnogo Vosstaniya Street, 664003-Irkutsk
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Review
For citations:
Rasulov R.I., Zemko M.V., Shelekhov A.V., Zubrinckiy K.G., Songolov G.I. COMPLICATIONS OF NEOADYAVANT THERAPY FOR CANCER OF THE HEAD OF THE PANCREAS. Siberian journal of oncology. 2019;18(3):20-25. (In Russ.) https://doi.org/10.21294/1814-4861-2019-18-3-20-25
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