ANALYSIS OF INFECTIOUS COMPLICATIONS IN CANCER PATIENTS DURING 2014-2016
https://doi.org/10.21294/1814-4861-2019-18-4-43-49
Abstract
The purpose of the study was to analyze infectious complications caused by multi-drug-resistant organisms depending on anticancer therapy.
Material and Methods. A total of 229 cancer patients with infectious complications of cancer therapy were included into the study.
Results. Lung cancer was the most predominant cancer (26.6 %) followed by gastric cancer (25.3 %) and esophageal cancer (14.4 %). Infectious complications occurring after surgery were observed in 83.4 % of the patients. Infectious complications caused by Acinetobacter baumannii were the most common (40.6 %), followed by Klebsiella pneumoniae (28.5 %), Pseudomonas aeruginosa (19.5 %), Staphylococcus spp. (9.4 %), and Enterococcus spp. (1.8 %).
Conclusion. Infectious complications occurred more frequently in postoperative cancer patients (p<0.02), and the ESKAPE group pathogens were the leading cause of these infections.
About the Authors
V. V. AginovaRussian Federation
Postgraduate, 24, Kashirskoe shosse, 115478-Moscow;
Lecturer, 6, Chuksin tupik, 127206-Moscow
N. V. Dmitrieva
Russian Federation
MD, DSc, Professor, Head of the Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients,
24, Kashirskoe shosse, 115478-Moscow
I. N. Petukhova
Russian Federation
MD, DSc, Leading Research Scientist, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients,
24, Kashirskoe shosse, 115478-Moscow
Z. V. Grigorievskaya
Russian Federation
MD, DSc, Senior Researcher, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients,
24, Kashirskoe shosse, 115478-Moscow
N. S. Bagirova
Russian Federation
MD, DSc, Leading Researcher, Laboratory of Microbiological Diagnosis and Treatment of Infections in Oncology,
24, Kashirskoe shosse, 115478-Moscow
I. V. Tereshchenko
Russian Federation
Research fellow, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients,
24, Kashirskoe shosse, 115478-Moscow
S. A. Dyakova
Russian Federation
Microbiologist, Laboratory of Microbiological Diagnosis and Treatment of Infections in Oncology,
24, Kashirskoe shosse, 115478-Moscow
T. A. Kalinchuk
Russian Federation
Laboratory Assistant, Laboratory of Microbiological Diagnosis and Treatment of Infections in Oncology,
24, Kashirskoe shosse, 115478-Moscow
A. I. Dmitrieva
Russian Federation
Microbiologist, Laboratory of Microbiological Diagnosis and Treatment of Infections in Oncology,
24, Kashirskoe shosse, 115478-Moscow
V. D. Vinnikova
Russian Federation
Student,
20/1, Delegatskaya Street, 127473-Moscow
References
1. WHO. Cancer [Internet]. URL: https://www.who.int/ru/news-room/fact-sheets/detail/cancer (cited: 01.05.2019).
2. UN News [Internet]. URL: https://news.un.org (cited: 01.05.2019).
3. Arruebo M., Vilaboa N., Sáez-Gutierrez B., Lambea J., Tres A., Valladares M., González-Fernández A. Assessment of the evolution of cancer treatment therapies. Cancers (Basel). 2011 Aug 12; 3(3): 3279–330. doi: 10.3390/cancers3033279.
4. Goldenshlyuger N.I. Surgical treatment of cancer: efficacy, methods and approaches, localization [Internet]. URL: http://onkolib.ru/lechenie-raka/operaciya (cited: 05.01.2019). (in Russian).
5. Dmitrieva N.V., Petukhova I.N., Smolyanskaya A.Z. Infectious complications in the oncological clinic. Practical Oncology. 2001; 1(5): 18–20. (in Russian).
6. Petukhova I.N., Dmitrieva N.V., Bagirova N.S., Grigorievskaya Z.V., Shilnikova I.I., Varlan G.V., Tereshchenko I.V. Postoperative infections in cancer patients. Malignant tumors. 2016; 4 (21). Suppl. 1: 48–53. (in Russian).
7. Kozlov R.S. Nosocomial infections: epidemiology, pathogenesis, prevention, control. Clinical Microbiology and Antimicrobial Chemotherapy. 2000; 2 (1): 16–30. (in Russian).
8. Dmitrieva N.V., Petukhova I.N., Bagirova N.C., Grigorievskaya Z.V., Dyakova S.A., Tereshchenko I.V., Sokolova E.N. Prevalence of nosocomial microorganisms in the oncological clinic. Russian Clinical laboratory diagnosis. 2016; 9: 109–110. [Internet] URL: https://rucont.ru/efd/487133 (in Russian).
9. Grigorievskaya Z.V., Petukhova I.N., Bagirova N.S., Shilnikova I.I., Tereshchenko I.V., Grigorievsky E.D., Dmitrieva N.V. Nasocomial infectoions in cancer patients: problem of gram-negative bacterial resistance. Siberian Journal of Oncology. 2017; 16(1): 91–97. (in Russian). doi: 10.21294/1814-4861 -2017-16-1-91-97.
10. Dmitrieva N.V., Grigorievskaya Z.V., Bagirova N.S., Petukhova I.N., Tereshchenko I.V., Shil’nikova I.I., Kulaga E.V., Kalinchuk T.A. Infections caused by multi-and pan-resistant microorganisms in an oncology clinic. Medical alphabet. 2016; 3(19): 48–49. (in Russian)].
11. Antimicrobial resistance surveillance in Europe 2016 [Internet]. URL: https://www.ecdc.europa.eu/en/publications-data/antimicrobialresistance-surveillance-europe-2016 (cited 01.05.2019).
12. WHO Global Strategy for Containment of Antimicrobial Resistance. World Health Organization. Geneva, 2001. [Internet]. URL: http://whqlibdoc.who.int/hq/2001/WHO_CDS_CSR_DRS_2001.2.pdf. (cited 01.05.2019).
13. WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index. [Internet]. URL: http://www.whocc.no/atcddd/. (cited 01.05.2019).
14. Gelfond V.M. Infectious complications in cancer patients. Practical oncology. 2009; 10 (3): 141–146. (in Russian).
Review
For citations:
Aginova V.V., Dmitrieva N.V., Petukhova I.N., Grigorievskaya Z.V., Bagirova N.S., Tereshchenko I.V., Dyakova S.A., Kalinchuk T.A., Dmitrieva A.I., Vinnikova V.D. ANALYSIS OF INFECTIOUS COMPLICATIONS IN CANCER PATIENTS DURING 2014-2016. Siberian journal of oncology. 2019;18(4):43-49. (In Russ.) https://doi.org/10.21294/1814-4861-2019-18-4-43-49