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THE VALUE OF PET/CT IN THE DIAGNOSIS, STADING AND MONITORING OF COLORECTAL CANCER

https://doi.org/10.21294/1814-4861-2019-18-4-67-77

Abstract

The purpose of the study was to provide up-to-date data on the efficacy of positron emission computed tomography (PET) for the diagnosis, assessment of tumor extension and monitoring of colorectal cancer.

Material and Methods. The Medline and Pubmed databases were used for searching for publications devoted to clinical trials of diagnostic value of PET with 18F-Ftordesoxyglucose (PET with 18F-FDG).

Results. Data on the value of PET with 18F-FDG in visualization of the primary tumor, detection of lymph node and distant metastases and assessment of the treatment response in patients with colorectal cancer were presented.

Conclusion. PET with 18F-FDG was shown to be a promising imaging method for colorectal cancer. It is the most sensitive method in the detection of liver metastases. 18F-FDG PET is particularly superior to CT and MET in the ability to assess tumor response to treatment and predict early tumor response to therapy. The development of new radiopharmaceuticals for the diagnosis, staging, monitoring and prediction of colorectal cancer is of great importance. 

About the Authors

V. I. Chernov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, DSc, Professor, Deputy Director for Science and Innovation, Head of Nuclear Medicine Department,

5, Kooperativny Street, 634009-Tomsk



N. M. Goncharova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, Junior Researcher, Chemotherapy Department,

5, Kooperativny Street, 634009-Tomsk



V. E. Goldberg
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, DSc, Professor, Head of Chemotherapy Department,

5, Kooperativny Street, 634009-Tomsk



E. A. Dudnikova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, Junior Researcher, Chemotherapy Department,

5, Kooperativny Street, 634009-Tomsk



R. V. Zelchan
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Radiologist, Nuclear Medicine Department,

5, Kooperativny Street, 634009-Tomsk



A. A. Medvedeva
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Senior Researcher, Nuclear Medicine Department,

5, Kooperativny Street, 634009-Tomsk



I. G. Sinilkin
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Senior Researcher, Nuclear Medicine Department,

5, Kooperativny Street, 634009-Tomsk



O. D. Bragina
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Junior Researcher, Nuclear Medicine Department,

5, Kooperativny Street, 634009-Tomsk



A. V. Avgustinovich
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Researcher, Abdominal Department,

5, Kooperativny Street, 634009-Tomsk



A. V. Goldberg
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, Junior Researcher, Department of Radiation Diagnostics,

5, Kooperativny Street, 634009-Tomsk



R. V. Ermolenko
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD. Postgraduate, Radiology Department,

5, Kooperativny Street, 634009-Tomsk



N. O. Popova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Senior Researcher, Chemotherapy Department,

5, Kooperativny Street, 634009-Tomsk



E. I. Simolina
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Researcher, Department of Chemotherapy,

5, Kooperativny Street, 634009-Tomsk



V. V. Vysotskaya
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science
Russian Federation

MD, PhD, Researcher, Chemotherapy Department,

5, Kooperativny Street, 634009-Tomsk



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43. Zeltchan R., Medvedeva A., Sinilkin I., Bragina O., Chernov V., Stasyuk E., Dergilev A. Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis. IOP Conference Series: Materials Science and Engineering. 2016; 012054.

44. Zelchan R.V., Medvedeva A.A., Sinilkin I.G., Bragina OD, Chernov V.I., Stasyuk E.S., Ilina E.A., Skuridin V.S. The study of the functional suitability of the tumororotropic radiopharmaceutical 99mTc-1-TIO-6-glucose in the experiment. Molecular medicine. 2018; 3 (16): 54–57. (in Russian).

45. Zeltchan R., Medvedeva A., Sinilkin I., Chernov V., Bragina O., Stasyuk E., Rogov A., Il'Ina E., Larionova L., Skuridin V., Dergilev A. Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis. IOP Conference Series: Materials Science and Engineering 8. VIII International Scientific Conference «Issues of Physics and Technology in Science, Industry and Medicine». 2016. 012054.

46. Chernov V.I., Dudnikova E.A., Zelchan R.V., Kravchuk T.L., Danilova A.V., Medvedeva A.A., Sinilkin I.G., Bragina O.D., Goldberg V.E., Goldberg A.V., Frolova I.G. The first experience of using 99mtc-1-thio-d-glucose for single-photon emission computed tomography imaging of lymphomas. Siberian Journal of Oncology. 2018; 17(4): 81–87. (in Russian). Doi: 10.21294/1814-4861-2018-17-4-81-87.


Review

For citations:


Chernov V.I., Goncharova N.M., Goldberg V.E., Dudnikova E.A., Zelchan R.V., Medvedeva A.A., Sinilkin I.G., Bragina O.D., Avgustinovich A.V., Goldberg A.V., Ermolenko R.V., Popova N.O., Simolina E.I., Vysotskaya V.V. THE VALUE OF PET/CT IN THE DIAGNOSIS, STADING AND MONITORING OF COLORECTAL CANCER. Siberian journal of oncology. 2019;18(4):67-77. (In Russ.) https://doi.org/10.21294/1814-4861-2019-18-4-67-77

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ISSN 1814-4861 (Print)
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