PRECLINICAL STUDIES OF α(1,2)-L-RAMNO-α(1,4)-D-GALACTOPIRANOZILURONAN FROM RHIZOMES ACORUS CALAMUS L. IN CANCER EXPERIMENT
Abstract
α(1,2)-L-ramno-α(1,4)-D-galaktopiranoziluronan from rhizomes Acorus calamus L. administered intravenously enhances the antitumor and antimetastatic efficacy of cyclophosphamide in mice with Lewis lung carcinoma, lung cancer – 67 and melanoma B-16.
About the Authors
K. A. Lopatina
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk; National Research Tomsk State University, Tomsk
Russian Federation
Russian Federation
T. G. Razina
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk
Russian Federation
Russian Federation
E. P. Zueva
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk; National Research Tomsk State University, Tomsk
Russian Federation
Russian Federation
S. G. Krylova
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk
Russian Federation
Russian Federation
A. M. Guryev
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
E. N. Amosova
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk
Russian Federation
Russian Federation
O. Y. Rybalkina
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk; National Research Tomsk State University, Tomsk
Russian Federation
Russian Federation
E. A. Safonova
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk
Russian Federation
Russian Federation
L. A. Efimova
Federal State Budgetary Scientific Institution «Research Institute of Pharmacology and Regenerative Medicine named after E.D. Goldberg, Tomsk
Russian Federation
Russian Federation
M. V. Belousov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
References
1. Gol'dberg E.D., Razina T.G., Zueva E.P., Amosova E.N., Krylova S.G., Gol'dberg V.E. Plants in complex oncotherapy. M., 2008. 232 p. [in Russian]
2. Zueva E.P., Lopatina K.A., Razina T.G., Gur'ev A.M. Polisaccharides in oncology. Tomsk: Pechatnaja manufaktura, 2010. 108 p. [in Russian]
3. Lakin G.F. Biometric. M., 1990. 352 p. [in Russian]
4. Guide to experimental (preclinical) study of new pharmacological substances / Ed. by R.U. Habriev. M., 2005. 832 p. [in Russian]
5. Safonova E.A., Gur’ev A.M., Razina T.G., Zueva E.P., Efimova L.A., Lopatina K.A. Increase the effectiveness of chemotherapy using pharmacologically active fractions isolated from the polysaccharide complex calamus (Acorus calamus L.) // Rossijskij bioterapevticheskij zhurnal. 2012. Vol. 11 (4). P. 55–58. [in Russian]
6. Safonova E.A., Lopatina K.A., Vetoshkina T.V., Razina T.G., Zueva E.P., Gur’ev A.M. Correction hepatotoxicity cyclophosphamide watersoluble polysaccharides Tussilago farfara ordinary and Acorus Calamus // Bjulleten’ sibirskoj mediciny. 2011. № 1. P. 70–75. [in Russian]
7. Safonova E.A., Lopatina K.A., Razina T.G., Fedorova E.P., Pahomova A.V., Vychuzhanina A.V., Zueva E.P., Efimova L.A. Correction of the toxic effect of paclitaxel on the blood system and the epithelium of the small intestine with water-soluble polysaccharides Tussilago farfara, Acorus Calamus and Echinacea purpurea // Rossijskij bioterapevticheskij zhurnal. 2010. Vol. 2 (9). P. 19–23. [in Russian]
8. Safonova E.A., Razina T.G., Lopatina K.A., Fedorova E.P., Zueva E.P., Gur’ev A.M. Reducing the toxicity of paclitaxel on the blood system water-soluble polysaccharides Tussilago farfara and Acorus Calamus // Sibirskij onkologicheskij zhurnal. 2010. № 2. P. 42–46. [in Russian]
9. Belska N.V., Guriev A.M., Danilets M.G., Trophimova E.S., Uchasova E.G., Ligatcheva A.A., Belousov M.V., Agaphonov V.I., Golovchenko V.G., Yusubov M.S., Belsky Y.P. Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response // Int. Immunopharmacol. 2010. Vol. 10 (8). P. 933–942. doi: 10.1016/j.intimp.2010.05.005.
10. Chetty C., Chetty C., Lakka S.S., Bhoopathi P., Rao J.S. MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells // Int. J. Cancer. 2010. Vol. 127 (5). P. 1081–1095. doi: 10.1002/ijc.25134.
11. Lee H., Lee H., Kim J.S., Kim E. Fuciodan from seaweed Fucus vesiculosus inhibits migration and invasion of human Lung Cancer cell via PI3K-AKT-mTOR pathways // PLOS One. 2012. Vol. 7. P. 506–524. doi: 10.1371/journal.pone.0050624.
Review
For citations:
Lopatina K.A., Razina T.G., Zueva E.P., Krylova S.G., Guryev A.M., Amosova E.N., Rybalkina O.Y., Safonova E.A., Efimova L.A., Belousov M.V. PRECLINICAL STUDIES OF α(1,2)-L-RAMNO-α(1,4)-D-GALACTOPIRANOZILURONAN FROM RHIZOMES ACORUS CALAMUS L. IN CANCER EXPERIMENT. Siberian journal of oncology. 2015;1(1):59-63. (In Russ.)
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