CLINICAL-IMMUNOLOGICAL ASSESSMENT OF EFFICACY OF NEOADJUVANT PHOTODYNAMIC THERAPY IN SURGICAL MANAGEMENT OF PRIMARY MELANOMA
Abstract
Efficacy of neoadjuvant photodynamic therapy (PDT) with photoditazine and radachlorine was assessed in 42 patients with stage I–III primary melanoma. The control group consisted of 42 patients with melanoma who underwent surgery alone. The 2.5-year overall and recurrence-free survival rates were significantly higher in patients who received neoadjuvant PDT than in the control group patients. Neoadjuvant PDT performed 2 days before surgery was found to promote the activation of T-and B-cell immunity. In the experimental study it was shown that the increase in time of laser irradiation of melanoma cell culture accompanied by a significant increase in the proportion of late apoptotic cells.
About the Authors
G. I. Gafton
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Gafton Georgij Ivanovich - MD, DSc.
Russian Federation
Gafton Georgij Ivanovich - MD, DSc.
V. V. Anisimov
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Anisimov Valentin Vadimovich - MD, DSc., Principal Investigator
Russian Federation
Anisimov Valentin Vadimovich - MD, DSc., Principal Investigator
M. L. Gelfond
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Gelfond Mark Lvovich - Senior Researcher
Russian Federation
Gelfond Mark Lvovich - Senior Researcher
Yu. V. Semiletova
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Semiletova Yulia Vadimovna
Russian Federation
Semiletova Yulia Vadimovna
I. A. Baldueva
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Baldueva Irina Aleksandrovna - MD, DSc.
Russian Federation
Baldueva Irina Aleksandrovna - MD, DSc.
Т. L. Nekhaeva
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Nekhaeva Tatjana Leonidovna
Russian Federation
Nekhaeva Tatjana Leonidovna
A. V. Novik
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Novik Aleksej Viktorovich - MD., PhD., Senior Researcher
Russian Federation
Novik Aleksej Viktorovich - MD., PhD., Senior Researcher
М. Yu. Myasnyankin
N.N. Petrov Research Institute of Oncology, St. Petersburg, Pesochny
Russian Federation
Myasnyankin Michael Jurevich
Russian Federation
Myasnyankin Michael Jurevich
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Review
For citations:
Gafton G.I., Anisimov V.V., Gelfond M.L., Semiletova Yu.V., Baldueva I.A., Nekhaeva Т.L., Novik A.V., Myasnyankin М.Yu. CLINICAL-IMMUNOLOGICAL ASSESSMENT OF EFFICACY OF NEOADJUVANT PHOTODYNAMIC THERAPY IN SURGICAL MANAGEMENT OF PRIMARY MELANOMA. Siberian journal of oncology. 2015;1(2):31-38. (In Russ.)
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