INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA
Abstract
Studies were conducted using ascetic HA-1 hepatomas and ascitic Ehrlich’s carcinoma cells. After passage of cells in mice, cell culture containing tumor-associated macrophages was studied. It was shown that the very low-density lipoprotein (VLDL)-cortisol complex significantly inhibited proliferative activity of tumor cells. The obtained constant of cortisol binding to VLDL indicated that the protein component of lipoproteins participated in the complex formation. Tumor-associated macrophages were suggested to play an important role in the formation of this complex. It was found that inhibition of tumor cell growth was related to apoptosis.
About the Authors
L. E. Panin
Research Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
Zh. I. Belonogova
Research Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
R. A. Knyazev
Research Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
I. O. Cheshenko
Research Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Panin L.E., Belonogova Zh.I., Knyazev R.A., Cheshenko I.O. INFLUENCE OF CORTISOL AND VERY LOW-DENSITY LIPOPROTEINES ON THE DEVELOPMENT OF HA-1HEPATOMA AND EHRLICH’S CARCINOMA. Siberian journal of oncology. 2013;(3):43-46. (In Russ.)
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