Preview

Siberian journal of oncology

Advanced search

COMBINED TREATMENT FOR EARLY-STAGE ENDOMETRIAL CANCER

Abstract

In spite of number of studies, including randomized, there is lack of consent on adjuvant radiotherapy for early-stage endometrial cancer. The literature and the results of own studies on combined treatment of this pathology are presented in this paper.

About the Authors

V. N. Nechushkina
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation


K Y. Morkhov
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation


V. V. Kuznetsov
N.N. Blokhin Russian Cancer Research Center RAMS
Russian Federation


References

1. Aaldders J., Abeler V., Kolstad P., Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients // Obstet. Gynecol. 1980. Vol. 56 (4). P. 419–427.

2. ASTEC/EN.5 Study Group, Blake P., Swart A.M. et al. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis // Lancet. 2009. Vol. 373 (9658). P. 137–146.

3. Boronow R.C., Morrow C.P., Creasman W.T. et al. Surgical staging in endometrial cancer: clinical-pathologic findings of a prospective study // Obstet. Gynecol. 1984. Vol. 63 (6). P. 825–832.

4. Cowles T.A., Magrina J.F., Masterson B.J. Comparison of clinical and surgical staging in patients with endometrial carcinoma // Obstet. Gynecol. 1985. Vol. 66 (3). P. 413–416.

5. Creasman W.T., Morrow C.P., Bundy B.N. et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study // Cancer. 1987. Vol. 60 (8). Suppl. P. 2035–2041.

6. Creasman W.T., Odicino F., Maisonneuve P. et al. Carcinoma of the Corpus Uteri // Int. J. Gynaecol. Obstet. 2006. Vol. 95. Suppl. 1. P. S105–144.

7. Creutzberg C.L., van Putten W.L., Koper P.C. et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma // Lancet. 2000. Vol. 355 (9213). P. 1404–1411.

8. Greven K.M., D’Agostino R.B. Jr., Lanciano R.M., Corn B.W. Is there a role for a brachytherapy vaginal cuff boost in the adjuvant management of patients with uterine-confined endometrial cancer? // Int. J. Radiat. Oncol. Biol. Phys. 1998. Vol. 42 (1). P. 101–104.

9. Johnson N., Cornes P. Survival and recurrent disease after postoperative radiotherapy for early endometrial cancer: systematic review and meta-analysis // BJOG. 2007. Vol. 114 (11). P. 1313–1320.

10. Keys H.M., Roberts J.A., Brunetto V.L. et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study // Gynecol. Oncol. 2004. Vol. 92 (3). P. 744–751.

11. Lindemann K., Onsrud M., Tropé C.G., Kristensen G.B. Long-term survival after radiation therapy for early stage endometrial carcinoma: the Oslo study revisited // Int. J. Gynecol. Cancer. 2012. Vol. 22 (8). Suppl. 3. P. E111.

12. McMeekin D.S., Alektiar K.M., Sabbatini P.J., Zaino R.J. Corpus: mesenchymal tumors. In: Principles and Practice of Gynecologic Oncology / Eds. R.R. Barakat, M. Markman, M.E. Randall. 5th ed. Wolters Kluwer. Lippincott Williams & Wilkins, 2009. P. 733–761.

13. NCCN Clinical Practice Guidelines In Oncology Uterine Neoplasms. Version 3.2012 [Электронный ресурс] URL: http://www.nccn.org/ professionals/physician_gls/pdf/uterine.pdf (дата обращения: 01.10.12).

14. Nout R.A., Smit V., Putter H. et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial // Lancet. 2010. Vol. 375 (9717). P. 816–823.

15. Schink J.C., Lurain J.R., Wallemark C.B., Chmiel J.S. Tumor size in endometrial cancer: a prognostic factor for lymph node metastasis // Obstet. Gynecol. 1987. Vol. 70 (2). P. 216–219.

16. Scholten A.N., van Putten W.L., Beerman H. et al. Postoperative radiotherapy for Stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology review // Int. J. Radiat. Oncol. Biol. Phys. 2005. Vol. 63 (3). P. 834–838.

17. Straughn J.M. Jr., Huh W.K., Kelly F.J. et al. Conservative management of stage I endometrial carcinoma after surgical staging // Gynecol. Oncol. 2002. Vol. 84 (2). P. 194–200.

18. Straughn J.M., Huh W.K., Orr J.W. Jr. et al. Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy // Gynecol. Oncol. 2003. Vol. 89 (2). P. 295–300.


Review

For citations:


Nechushkina V.N., Morkhov K.Y., Kuznetsov V.V. COMBINED TREATMENT FOR EARLY-STAGE ENDOMETRIAL CANCER. Siberian journal of oncology. 2013;(3):70-74. (In Russ.)

Views: 782


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)