Quality of life of patients with locally advanced breast cancer after neutron therapy

Quality of life of 42 patients with locally advanced breast cancer (T2-4N0-3M0) after combined modality treatment including either neutron therapy or photon therapy was studied. The EORTC QLQ-30 (version 3.0) and EORTC QLQ -BR-23 questionnaires were used. A slight decrease in the physical and emotional state and nausea/vomiting were observed in the group of patients who received neutron therapy (n=20) as well as in the group of patients who received photon therapy (n=22). In patients of the neutron therapy group, an increase in the index of dyspnea by 6 points (with the baseline index of 15.0 ± 5.7 points) was observed. The dyspnea index decreased to 5.26 ± 2.9 points 12 months later in patients having no evidence of disease progression. Local pulmonary fibrosis was diagnosed in 2 (10 %) of 20 breast cancer patients. In photon therapy group patients, an increase in the index of dyspnea by 11 points (with the baseline index of 14.3 ± 5.1 points) was observed. In 12 months, the dyspnea index decreased to 7.1 ± 3.1 points. Local pulmonary fibrosis was diagnosed in 4 (18 %) of 22 patients. A moderate decline in the general health status was observed in both groups of patients after neutron therapy delivered to the anterior chest wall. However, all patients with locally advanced breast cancer subjectively noted the rise of the general health status 12 months after completion of treatment (78.3 ± 4.2 points, respectively). Thus, postoperative neutron therapy delivered to the anterior chest wall did not increase the frequency of complications and did not affect the quality of life of breast cancer patients.

1. Kaprin A.D., Starinsky V.V., Petrova G.V. Malignant neoplasms in Russia in 2016 (morbidity and mortality). Moscow, 2018, 250 p. (in Russian).

2. Khailenko VA., Komov D.V Oncommammology. Moscow, 2015. 328 p. (in Russian).

3. Krushnaya NA., Teske G.P. The impact of psychological counseling on the women quality of life in crisis, associated with health. Bulletin of Chelyabinsk State Pedagogical University. 2016; 3: 120-124. (in Russian).

4. Kaminska M., Ciszewski T., Kukielka-Budny B., Kubiatowski T., Baczewska B., Makara-Studzinska M., Staroslawska E., Bojar I. Life guality of women with breast cancer after mastectomy or breast conserving therapy treated with adjuvant chemotherapy. Ann Agric Environ Med. 2015; 22(4): 724-30. doi: 10.5604/12321966.1185784.

5. Startseva Zh.A., Velikaya VV, Simonov K.A., Musabaeva L.I. Postoperative radiation therapy for prevention of breast cancer local recurrence. Radiation and Risk. 2013; 22(3): 72-79. (in Russian).

6. DeminaEA., Ivankova Vs. Tumor radiation resistance: causes and mechanisms. Ukrainian radiological journal. 2012; 20 (2): 151-3. (in Russian).

7. Gribova O.V., Musabaeva L.I., Choynzonov E.L., Lisin V.A., Novikov V.A. Neutron therapy for salivary and thyroid gland cancer. AIP Conference Proceedings. 2016. 020021.

8. Zhogina ZhA., MusabaevaL.I., BalatskayaL.N., Slonimskaya E.M. Life quality of patients with locally advanced breast cancer as an assessment criterium of complex treatment with the use of 6.3 mev fast neutrons. Siberian Journal of Oncology. 2007; 4: 36-43. (in Russian).

9. NovikA.A., Ionova T.I. Guide to the study of quality of life in medicine. Moscow, 2002. 313 p. (in Russian).

10. ChoinzonovE.L., BalatskayaL.N. Quality of life for cancer patients. Tomsk, 2012. 152 p. (in Russian).

11. Chizhevskaya S.Yu., Cho-inzonov E.L., Balatskaya L.N. Quality of life in patients with laryngeal and laryngopharyngeal cancer in short-and long-term follow-up. Siberian Journal of Oncology. 2015; 2: 15-22. (in Russian).

12. Sharma N., Purkayastha A. Impact of radiotherapy on psychological, financial, and sexual aspects in postmastectomy carcinoma breast patients: A prospective study and management. Asia Pac J Oncol Nurs. 2017 Jan-Mar; 4(1): 69-76. doi: 10.4103/2347-5625.199075.

13. Velikova G., Williams L.J., Willis S., Dixon J.M., Loncaster J., Hatton M., Clarke J., Kunkler I.H., Russell N.S.; MRC SUPREMO trial UK investigators. Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomized, controlled trial. Lancet Oncol. 2018 Nov; 19(11): 1516-1529. doi: 10.1016/S1470-2045(18)30515-1.

14. Meattini I., Saieva G., Miccinesi G., Desideri I, Francolini G., Scotti V, Marrazzo L., Pallotta S., Meacci F., Muntoni C., Bendinelli B., Sanchez L.J., Bernini M., Orzalesi L., Nori J., Bianchi S., Livi L. Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: Health-related quality of life final analysis from the Florence phase 3 trial. Eur J Cancer. 2017 May; 76: 17-26. doi: 10.1016/j.ejca.2017.01.023.