EXPRESSION MICRORNA IN LARYNX CANCER
Abstract
MicroRNA are nonprotein-coding small ribonucleic acids controlling gene expression at post-transcriptional level. MicroRNA technically could controll 2/3 of human genome. At the present study abnormal expression of microRNA-18а, -21, -155, -200а, -200с, -205, -221, -494 in malignant tissue of squamous cell larynx carcinoma of 46 patients were studied. There was no statistically significant correlation between microRNA expression and pathological characteristics. Our data showed that oncogenic microRNA-21, -155, -205 were overexpressed as well as oncosypression microRNA-200a were underexpressed in larynx cancer compared to adjacent normal epithelium.
About the Authors
E. G. Nikitina
Tomsk Cancer Research Institute, Tomsk; Tomsk State University, Tomsk
Russian Federation
Russian Federation
Nikitina Ekaterina Gennadievna - M.S., Junior Researcher of the Laboratory of Oncovirology, Tomsk Cancer Research Institute; Junior Researcher of Tomsk State University.
Phone: +7 3822 51-29-57. E-mail: ekatarinanikitina@gmail.com
O. V. Cheremisina
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Cheremisina Olga Vladimirovna - MD., DSc, Professor, Head of the Endoscopy Department of Tomsk Cancer Research Institute.
Phone: +7 3822 41-80-91. E-mail: CheremisinaOV@oncology.tomsk.ru
V. A. Bychkov
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Bychkov Viacheslav Alekseevich - MD., PhD., Senior Researcher of the Laboratory of Oncovirology, Tomsk Cancer Research Institute; Junior Researcher of Tomsk State University.
Phone: +7 3822 51-29-57. E-mail: va.bych@gmail.com
D. E. Kulbakin
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Kulbakin Denis Evgenievic - MD., PhD., Junior Researcher of the Head and Neck Department, Tomsk Cancer Research Institute.
Phone: +7 3822 41-80-62. E-mail: kulbakin_d@mail.ru
E. L. Choinzonov
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Choynzonov Evgeny Lhamatsirenovich - MD., Academician of RAN, Professor, Director of Tomsk Cancer Research Institute
Phone: +7 3822 51-10-39. E-mail: nii@oncology.tomsk.ru
V. N. Stegniy
Tomsk State University, Tomsk
Russian Federation
Russian Federation
Stegniy Vladimir Nikolaevich - MD., DSc, Professor, Head of the Cytology and Genetics Department of Biology Institute of Tomsk State University.
Phone: +7 3822 52-97-52. E-mail: stegniy@ref.tsu.ru
N. V. Litviakov
Tomsk Cancer Research Institute, Tomsk; Tomsk State University, Tomsk
Russian Federation
Russian Federation
Litviakov Nikolay Vasilievich - MD., DSc, Head of the Laboratory of Oncovirology, Tomsk Cancer Research Institute; Senior Researcher of Tomsk State University.
Phone: +7 3822 51-46-07. E-mail: nvlitv72@yandex.ru
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Review
For citations:
Nikitina E.G., Cheremisina O.V., Bychkov V.A., Kulbakin D.E., Choinzonov E.L., Stegniy V.N., Litviakov N.V. EXPRESSION MICRORNA IN LARYNX CANCER. Siberian journal of oncology. 2015;1(2):46-52. (In Russ.)
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