Polyneoplasia associated with gastrointestinal stromal tumor: literature review and case report
N. V. Vasilyev,
V. A. Markovich,
I. G. Frolova,
R. V. Ermolenko,
A. A. Maltseva,
О. I. Kovalev,
P. G. Lyutikova https://doi.org/10.21294/1814-4861-2020-19-2-140-146
Abstract
The purpose of the study was to demonstrate a rare clinical case of polyneoplasia associated with GIST, combining three malignant neoplasms of different nosological affiliation and different tissue origin. Scientific interest is caused by the need to study polyneoplasia associated with Gist, which can be explained by the concept of Rodriquenz M.G. et al. (2016), suggesting the special role of a solitary GisT in the potential development of polyneoplasia.
Material and Methods. The search for relevant sources was carried out in the Medline, Cochrane Library, Elibrary systems, includibg publications from January 2009 to October 2019. Of the 507 studies, 21 were used to write a systematic review.
Results. In the vast majority of cases, polyneoplasia is represented by two malignant neoplasms in a single patient. Primary multiple metachronous and primary multiple synchronous tumors with three or more tumors are observed very rarely. Among all multiple primary tumors, our attention was drawn to polyneoplasia containing GisT. A neoplasm associated with a GisT is localized mainly in the gastrointestinal tract, and also occurs in the organs of the urinary system, female genital system, thyroid gland, breast, lungs, and testicles.
Conclusion. This clinical case is a rather rare phenomenon of polyneoplasia associated with GisT of rectum, which combines three malignant neoplasms. It should be noted that primary Gist in the rectum occurs in 4% of cases.
About the Authors
N. V. Vasilyev
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Nikolai V. Vasilyev - MD, PhD, Senior Researcher, Department of General and Molecular Pathology, Researcher ID (WOS): D-1144-2012. Author ID (Scopus): 57192110276.
5, Kooperativny Street, 634050 Tomsk
V. A. Markovich
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Vitaly A. Markovich - MD, Junior Researcher, Department of Thoracic Oncology.
5, Kooperativny Street, 634050 Tomsk
I. G. Frolova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Irina G. Frolova - MD, Professor, Head of Diagnostic Imaging Department, Researcher ID (WOS): C-8212-2012. Author ID (Scopus): 7006413170.
5, Kooperativny Street, 634050 Tomsk
R. V. Ermolenko
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Roman V. Ermolenko - Postgraduate, Imaging Department.
5, Kooperativny Street, 634050 Tomsk
A. A. Maltseva
Siberian State Medical University
Russian Federation
Russian Federation
Anastasia A. Maltseva - MD, Oncology Department, Siberian State Medical University (Tomsk, Russia).
2, Moskovsky Trakt Street, 634050 Tomsk
О. I. Kovalev
Siberian State Medical University
Russian Federation
Russian Federation
Oleg I. Kovalev - MD, Oncology Department, Siberian State Medical University (Tomsk, Russia).
2, Moskovsky Trakt Street, 634050 Tomsk
P. G. Lyutikova
Siberian State Medical University
Russian Federation
Russian Federation
Polina O. Lyutikova - MD, Oncology Department, Siberian State Medical University (Tomsk, Russia).
2, Moskovsky Trakt Street, 634050 Tomsk
References
1. Renda A. Multiple Primary Malignancies. Springer Science & Business Media, 2009. 287 p.
2. Rodriquenz M.G., Rossi S., Ricci R., Martini M., Larocca M., Dipasquale A., Quirino M., Schinzari G., Basso M., D’Argento E., Strip-poli A., Barone C., Cassano A. Gastrointestinal stromal tumors (GISTs) and second malignancies A novel “sentinel tumor”? A monoinstitutional, STROBE-compliant observational analysis. Medicine (Baltimore). 2016 Sep; 95(38): e4718. doi: 10.1097/MD.0000000000004718.
3. YamamotoD., Hamada Y., Tsubota Y., KawakamiK., Yamamoto C., Yamamoto M. Simultaneous development of adenocarcinoma and gastro-intestinal stromal tumor (GIST) in the stomach: case report. World J Surg Oncol. 2012. 10: 6. doi: 10.1186/1477-7819-10-6.
4. Kumar K., Rowsell C., Law C., Ko Y.-J. Coexistence of gastrointestinal stromal tumour and colorectal adenocarcinoma: Two case reports. J Gastrointest Oncol. 2011; 2: 50-54. doi: 10.3978/j.issn.2078-6891.2010.029.
5. Ferreira S.S., Werutsky G., Toneto M.G., Alves JM., Pianta C.D., Breunig R.C., da Rocha A.B., Grivicich I., Garicochea B. Synchronous gastrointestinal stromal tumors (GIST) and other primary cancers: Case series of a single institution experience. Int J Surg. 2010; 8: 314—317. doi: 10.1016/j.ijsu.2010.03.008.
6. Telugu R.B., Pushparaj M., Masih D., Pulimoo A. Synchronous Appearance of Adenocarcinoma and Gastrointestinal Stromal Tumour (GlST) ofthe Stomach: A Case Report. J Clin Diagn Res. 2016 Feb; 10(2): ED16-8. doi: 10.7860/JCDR/2016/17636.7289.
7. Huang Y.C., Wang J.Y., Lin P.Y., Chin C.C., Chen C.S. Synchronous prostate stromal sarcoma and Gastrointestinal stromal tumor of rectum: Case report and review of the literature. Urology. 2006; 68: 672.e11-672. e13. doi: 10.1016/j.urology.2006.03.018.
8. Reith J.D., Goldblum J.R., LylesR.H., Weiss S.W Extragastrointestinal (Soft Tissue) Stromal Tumors: An Analysis of 48 Cases with Emphasis on Histologic Predictors of Outcome. Mod Pathol. 2000; 13 (5): 577-585. doi: 10.1038/modpathol.3880099.
9. Fletcher C.D.M., Bridge J.A., Hogendoorn P.C.W., Mertens F. WHO Classification of Tumours of Soft Tissue and Bone. IARC: Lyon, 2013. 468 p.
10. JiangM.J., Weng S.S., Cao Y, LiX.F., WangL.H., Xu J.H., Yuan Y Metachronous Primary Adenocarcinoma of Lung During Adjuvant Imatinib Mesylate Therapy for Gastrointestinal Stromal Tumor of Stomach. A Case Report. Medicine (Baltimore). 2015 Sep; 94(36): e1484. doi: 10.1097/MD.0000000000001484.
11. Kramer K., Wolf S., Mayer B., Schmidt S.A., Agaimy A., Henne-Bruns D., Knippschild U., Schwab M., Schmieder M. Frequence, Spectrum and Prognostic Impact of Additional Malignancies in Patients With Gastrointestinal Stromal Tumors. Neoplasia. 2015 Jan; 17(1): 134-40. doi: 10.1016/j.neo.2014.12.001.
12. Pandurengan R.K., Dumont A.G., Araujo D.M., Ludwig J.A., Ravi V., Patel S., Garber J., Benjamin R.S., Strom S.S., Trent J.C. Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol. 2010; 21: 2107-11. doi: 10.1093/annonc/mdq078.
13. Murphy J.D., Ma G.L., Baumgartner J.M., Madlensky L., Bur-goyne A.M., Tang C.-M., Martinez M.E., Sicklick J.K. Increased Risk of Additional Cancers Among Patients With Gastrointestinal Stromal Tumors: A Population-Based Study. Cancer. 2015 Sep 1; 121(17): 2960-7. doi: 10.1002/cncr.29434.
14. Agaimy A., Wunsch P.H., Sobin L.H., Lasota J., Miettinen M. Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol. 2006; 23: 120-129. doi: 10.1053/j.semdp.2006.09.004.
15. JayantK., AgrawalS., AgarwalR. Jejunal Gastrointestinal Stromal Tumor Associated with Synchronous Periampullary Adenocarcinoma - A Case Report. Am J Med Case Rep. 2014; 2(1): 12-15. doi: 10.12691/ajmcr-2-1-4.
16. Dincer M., Citlak G., Hut A., Tigrel L. Z., Benli C. Synchronous gastrointestinal stromal Tumor and Adenocarcinoma in the stomach. Natn J Lab Med. 2017; 6(1): PC07PC08. doi: 10.7860/NJLM/2017/24604:2201.
17. Vasilakaki T., KouliaK., TsavariA., ArkoumaniE., KouroumpasE., Pavlis A., Christopoulos G., Stamatiou K., Manoloudaki K., Zisis D. Synchronous Gastric Gastrointestinal Stromal Tumor and Colon Adenocarcinoma: A Case Report. Hindawi Publishing Corporation. Case Rep Oncol Med. 2014; 2014: 305848. doi: 10.1155/2014/305848.
18. Kurihara Y., Sakai Y., Tomita T. Complete response to imatinib mesylate treatment in jejuna leiomyosarcoma subsequently developing gastrointestinal stromal tumor and desmoids tumor. Am J Exp Clin Res. 2014; 1 (1): 11-15.
19. Fahin S., Sefkin S., Arslan E., Qaglayan K., Zengin K., Tanik S. Triple Synchronous Tumors in a Patient: Gastric Adenocarcinoma, Omental Gastrointestinal Stromal Tumor and Renal Angiomyolipoma. Am J Cancer. 2014; 2(2): 1-10.
20. Grobmyer S.R., LutherN., Antonescu C.R., Singer S., BrennanM.F. Multiple primary soft tissue sarcomas. Cancer. 2004; 101: 2633-2635.
21. Rebegea L.F., Patra^cu A., Miron D., Dumitru M.E., Firescu D. Metachronous gastrointestinal stromal tumor associated with other neoplasia - case presentation. Rom J Morphol Embryol. 2016; 57(4): 1429-1435.
Review
For citations:
Vasilyev N.V., Markovich V.A., Frolova I.G., Ermolenko R.V., Maltseva A.A., Kovalev О.I., Lyutikova P.G. Polyneoplasia associated with gastrointestinal stromal tumor: literature review and case report. Siberian journal of oncology. 2020;19(2):140-146. (In Russ.) https://doi.org/10.21294/1814-4861-2020-19-2-140-146
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