COMPARATIVE ANALYSIS OF THE RADIATION EXPOSURE ON THE TARGET AND CRITICAL ORGANS WITH 2D AND 3D PLANNING OF RADIATION THERAPY FOR LUNG CANCER
Abstract
Background and purpose. The purpose of this investigation was to evaluate feasibility, safety and efficacy of radiotherapy for inoperable non-small-cell lung cancer (NSCLC). Various radiotherapy planning methods have been proposed to decrease normal tissue toxicity. We compared 2D-RT with 3D-RT for NSCLC. Parameters assessed included dose to PTV and organ-at-risk (OAR), multiple conformity and homogeneity indices. Material and methods. Initial and re-simulation CT images from 52 consecutive patients with IIB – IIIB NSCLC were used to quantify dosimetric differences between 2D and 3D conformal radiotherapy. Contouring was performed on both CTs, and plans (n=104 plans) and dose-volume histograms were generated. Results. All plans provided comparable PTV coverage. Compared with 2D-RT, 3D-RT significantly reduced the maximum dose to heart (p<0.01), spinal cord (p<0.01), whole lung (p<0.01), esophagus (p<0.02) – Wilcoxon test.
About the Authors
I. A. Gulidov
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Gulidov Igor Alexandrovich, MD, Professor, Head of External Beam Radiation Therapy Department.
E-mail: iagulidov@mrrc. obninsk.ru. SPIN-code: 2492-5581
I. N. Ivanova
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Ivanova Irina Nikolaevna, MD, PhD, radiologist, External Beam Radiation Therapy Department.
E-mail: ivanirka@gmail. com. SPIN-code: 5950-0917
D. V. Gogolin
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Gogolin Danil Vyacheslavovich, radiologist, External Beam Radiation Therapy Department.
E-mail: dgogolin@yandex.ru. SPIN-code: 7491-3379
A. I. Gorsky
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Gorsky Anton Igorevich, Leading Researcher, Laboratory of Assessment of Radiation Risks and Mathematical Modeling.
Phone: +7 (484) 939-32-60. E-mail: gorsky@nrer.ru
L. V. Kursova
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Kursova Larisa Viktorovna, MD, PhD, Leading research fellow, Department of Surgical and Conservative Treatment of Radiationinduced Damage.
E-mail: larisa@mrrc.obninsk.ru. SPIN-code: 4852-3241
A. Ju. Bouksha
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Buksha Anna Yurievna, engineer, Department of Clinical Topometry and Dosimetry nduced Damage.
Phone: +7 (484) 399-30-35. E-mail: a.bouksha@mail.ru. SPIN-code: 9184-2186
Yu. A. Ragulin
A.F. Tsyba Medical Radiological Research Center affiliated to P.A. Gertsen Moscow Cancer Research Institute, Obninsk
Russian Federation
Russian Federation
Ragulin Yuriy Alexandrovich, MD, PhD, Head of Department of Thoracic Radiotherapy and Surgery with Group of Breast Cancer Treatment.
E-mail: yuri.ragulin@mail.ru. SPIN-code: 6453-6594
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Review
For citations:
Gulidov I.A., Ivanova I.N., Gogolin D.V., Gorsky A.I., Kursova L.V., Bouksha A.J., Ragulin Yu.A. COMPARATIVE ANALYSIS OF THE RADIATION EXPOSURE ON THE TARGET AND CRITICAL ORGANS WITH 2D AND 3D PLANNING OF RADIATION THERAPY FOR LUNG CANCER. Siberian journal of oncology. 2015;1(5):14-20. (In Russ.)
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