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NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL

Abstract

Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma. Materials and methods: One hundred and thirteen surgical specimens of squamous cell lung cancer were studied using double staining for Ki-67 antigen (MIB-1 clone, DAKO) by immunohistochemistry and for Ag-ЯОР-proteins with silver nitrate. results: In squamous cell carcinoma, the Ag-NOR area in Ki-67 positive cells correlated with the clinical and morphological parameters: parameter T, the greatest tumor size, parameter N, stage of the disease and tumor differentiation. When the area of Ag-ЯОР-proteins in Ki-67 positive cells was small, the long-term survival rates were higher.   The Ag-ЯОР area in Ki-67 positive cells is an independent prognostic factor in squamous cell lung cancer.

About the Authors

D. S. Kobyakov
Kogalym Municipal Hospital, Kogalym
Russian Federation

Kobyakov Dmitriy Sergeevich - M.D., PhD.
E-mail: dskob@yandex.ru



A. F. Lazarev
Altai branch of the N.N. Blokhin Russian Cancer Research Center, RAMS, Barnaul
Russian Federation

Lazarev Aleksandr Fedorovich - MD, DSc, Professor, Director of the Altai branch N.N. Blokhin Russian Cancer Research Center
E-mail: aoc@ctmed.ru



Е. L. Lushnikova
Research Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk
Russian Federation

Lushnikova Elena Leonidovna - DSc, Professor, FGBU (Federal State Budgetary Institution) Research Institute of regional pathology and pathomorphology SO (Siberian Department) RAMS.
Tel.: 8 (383)-333-48-45. E-mail: pathol@soramn.ru



L. М. Nepomnyaschikh
Research Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk
Russian Federation

Nepomnyashchikh Lev Moiseevich - MD, DSc, Associate Member of RAS, Professor, Director of the FGBU (Federal State Budgetary Institution) Research Institute of regional pathology and pathomorphology SO (Siberian Department) RAMS
Tel.: 8 (383)-333-48-45. E-mail: pathol@soramn.ru



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For citations:


Kobyakov D.S., Lazarev A.F., Lushnikova Е.L., Nepomnyaschikh L.М. NUCLEAR ORGANIZERS IN KI-67 POSITIVE CELLS OF SQUAMOUS CELL LUNG CANCER: CLINICAL MORPHOLOGICAL PARALLELS AND SURVIVAL. Siberian journal of oncology. 2015;1(2):58-63. (In Russ.)

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)