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PREMALIGNANT LESIONS AND SYNCHRONOUS GASTRIC CANCER IN PATIENTS WITH LUNG AND HEAD AND NECK CANCER

Abstract

The paper presents the analysis of the frequency of synchronous gastric and esophageal carcinomas in 176 patients with primary respiratory tract cancer, 122 (69.3%) of them with head and neck cancer and 54 (30.7%) with lung cancer.  The endoscopic examination revealed synchronous gastric cancer (n=4) and synchronous esophageal cancer (n=1) in 5 (2.8 %) cases (3 with primary lung cancer and 2 with primary laryngeal cancer). These patients received anticancer treatment for synchronous polyneoplasias. Ninety-one (51.7 %) patients had gastric mucosal atrophy, which in 25.7 % of cases was characterized as premalignant lesions: grade I-II dysplasia (20.2%) and grade III dysplasia (5.5%).  Considering the data obtained, patients with respiratory tract cancer have an increased risk for developing gastric and esophageal cancer. Endoscopic esophageal and gastric examination using advanced technologies should be included in the algorithm of management of these patients.

About the Authors

О. V. Cheremisina
Tomsk Cancer Research Institute
Russian Federation

Cheremisina Olga Vladimirovna MD., DSc, Professor, Head of the Endoscopy Department.
Phone: +7 3822 41-80-91. E-mail: CheremisinaOV@oncology.tomsk.ru



К. Yu. Menshikov
Tomsk Cancer Research Institute
Russian Federation

Меньшиков Кирилл Юрьевич - MD, Endoscopy Department.
Телефон: +7 (3822) 418094



S. G. Afanasyev
Tomsk Cancer Research Institute
Russian Federation

Afanasjev Sergey Gennadjevich - MD, DSc., Leading researcher, Thoracal and Abdominal Department.
E-mail: AfanasievSG@oncology.tomsk.ru



M. V. Vusik
Tomsk Cancer Research Institute
Russian Federation

Vusik Marina Vladimirovna - MD, DSc., Leading researcher, Endoscopy Department.
Телефон: +7 (3822) 418094



References

1. Agabekyan G.O., Kropotov M.A., Saprina O.A., Stelmakh D.K., Park M.B. Second primary cancer in patients with head and neck squamous cell carcinoma (review of the literature) // Sovremennaja onkologija. 2014. Vol. 16 (2). P. 82–86. [in Russian]

2. Bisenkov L.N., Gaidar B.V., Shanin Yu.N., Parfenov V.E., Shalaev S.A., Orzheshkovsky O.V., Kuznetsov I.M., Gunyat R.Ya. Single-stage operations for synchronous multiple primary and metastatic cancer of the lung and other organs // Vestnik hirurgii im. I.I. Grekova. 2006. Vol. 165 (6). P. 9–16. [in Russian]

3. Vazhenin A.V., Behtereva E.I., Behtereva S.A., Gjulov H.Ja. Multiple primary cancers. Cheljabinsk: Ieroglif, 2000. 170 p. [in Russian]

4. Lenshin A.V., Il’in A.V., Odireev A.N., Krajnov S.A., Poberezhskij A.V. Primary synchronous multicentric lung polyneoplasia (clinical and radiological follow-up, literature review) // Bjulleten’ fiziologii i patologii dyhanija. 2014. № 53. P. 114–125. [in Russian]

5. Multiple-primary cancers / Eds. V.I. Chissov, A.H. Trahtenberg. M., 2000. [in Russian]

6. Skoropad V.Yu., Berdov B.A., Kozlov I.G. Metachronic malignant tumors in patients radically operated on gastric cancer // Sibirskij onkologicheskij zhurnal. 2010. № 6. P. 5–11. [in Russian]

7. Amer M.H. Multiple neoplasms, single primaries, and patient survival // Cancer Manag Res. 2014. Vol. 5 (6). P. 119–134. doi: 10.2147/CMAR.S57378.

8. Griffioen G.H., Louie A.V., de Bree R., Smit E.F., Paul M.A., Slotman B.J., Leemans C.R., Senan S. Second primary lung cancers following a diagnosis of primary head and neck cancer // Lung Cancer. 2015. Vol. 88 (1). P. 94–99. doi: 10.1016/j.lungcan.2015.01.011.

9. Lee G.D., Kim Y.H., Kim J.B., Choi S.H., Kim H.R., Kim D.K., Park S.I. Esophageal Cancer Associated with Multiple Primary Cancers: Surgical Approaches and Long-term Survival // Ann. Surg. Oncol. 2013. Vol. 20 (13). P. 4260–4266. doi: 10.1245/s10434-013-3183-3.

10. Li L., Yang L., Liu Y., Zhao C., Lin D., Wu N., Liu X., Gao Y. Study on 21 cases of multiple primary lung cancer // Zhonghua Yi Xue Za Zhi. 2014. Vol. 94 (11). P. 844–847.

11. Marchioni A., Lasagni A., Busca A., Cavazza A., Agostini L., Migaldi M., Corradini P., Rossi G. Endobronchial metastasis: an epidemiologic and clinicopathologic study of 174 consecutive cases // Lung Cancer. 2014. Vol. 84 (3). P. 222–228. doi: 10.1016/j.lungcan.2014.03.005.

12. Son C., Lee S.K., Choi P.J., Roh M.S. Characteristics of additional primary malignancies in Korean patients with non-small cell lung cancer // J. Thorac. Dis. 2013. Vol. 5 (6). P. 737–744. doi: 10.3978/j.issn.2072-1439.2013.11.23.

13. Vo D.T., Nakayama T., Yamamoto H., Mukaisho K., Hattori T., Sugihara H. Progression risk assessments of individual non-invasive gastric neoplasms by genomic copy-number profile and mucin phenotype // BMC Med. Genomics. 2015. Vol. 8 (1). P. 6. doi: 10.1186/s12920-015-0080-6

14. Wolff H.A., Wolff C.R., Hess C.F., Jung K., Sennhenn-Kirchner S., Hinterthaner M., Müller-Dornieden A., Körber W., Marten-Engelke K., Roedel R., Christiansen H., Engelke C. Second primary malignancies in head and neck cancer patients: high prevalence of curable-stage disease // Strahlenther. Onkol. 2013. Vol. 189 (10). P. 874–880. doi: 10.1007/s00066-013-0404-4.


Review

For citations:


Cheremisina О.V., Menshikov К.Yu., Afanasyev S.G., Vusik M.V. PREMALIGNANT LESIONS AND SYNCHRONOUS GASTRIC CANCER IN PATIENTS WITH LUNG AND HEAD AND NECK CANCER. Siberian journal of oncology. 2015;1(2):76-80. (In Russ.)

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)