MICRORNA EXPRESSION PROFILE ALTERATIONS IN MELANOMA AND MELANOMA MICROENVIRONMENT
Abstract
Melanoma of the skin is considered as multiplex neoplastic system characterized by high tumor heterogeneity. MicroRNAs are a class of epigenetic regulators by which 90 % of human genome is controlled. At the present time more than 1 500 types of microRNAs is identified. Comparative analysis of microRNA expression profile is performed in melanoma, melanocytic nevi and tumor microenvironment in the present study. The differences of microRNA expression levels should be under further consideration to evaluate their functional significance in melanomagenesis and possible application as melanoma prognostic and diagnostic markers.
About the Authors
A. V. Komina
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Komina Anna Vladimirovna, Researcher, Department of Pathological Physiology.
E-mail: komivlann@yandex.ru. SPIN-code: 1172-2769
M. B. Aksenenko
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Aksenenko Maria Borisovna, MD, PhD, lecturer, Department of Pathological Physiology.
E-mail: aksenenko_mariya@mail.ru. SPIN-code: 6958-9122
N. V. Palkina
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Palkina Nadezhda Vladimirovna, postgraduate, Department of Pathological Physiology.
E-mail: MosmanNV@yandex.ru
S. A. Artemiev
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Artemiev Sergey Alexandrovich, MD, DSc, Associate Professor, Department of Pathological Physiology.
Phone: 8 (3912) 97-96-97. E-mail: skyman1977@mail.ru. SPIN-code: 8049-0119
T. G. Ruksha
Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Russian Federation
Ruksha Tatiana Gennadievna, MD, DSc, Head of Department of Pathological Physiology.
E-mail: tatyana_ruksha@mail.ru. SPIN-code: 5412-2148
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Review
For citations:
Komina A.V., Aksenenko M.B., Palkina N.V., Artemiev S.A., Ruksha T.G. MICRORNA EXPRESSION PROFILE ALTERATIONS IN MELANOMA AND MELANOMA MICROENVIRONMENT. Siberian journal of oncology. 2015;1(5):67-73. (In Russ.)
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