Photodynamic therapy in surgical treatment of patients by a skin melanom
Abstract
In experimental and clinical research carried out studying of influence of neoadjyuvant photodynamic therapy on T- and B-cellular immune answer in surgical treatment of patients of a melanoma of skin of the I–III stage. PDT was executed to 25 patients two days prior to surgical removal of primary tumor from July, 2012 to January, 2013. As a result of the conducted research it was revealed that: the increase in concentration fotoditaziny doesn‘t lead to increase in quantity of tumoral cages at stages early apoptosis; lengthening of time of an exposition leads to increase in a share of late forms apoptosis, and FDT use with fotoditaziny in a dose of 50,0 mg with the subsequent radiation (662 nanometers, 400 J) in 2 days prior to surgical intervention promotes T- and B-cellular link of immune system.
About the Authors
G. I. Gafton
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
Yu. V. Semiletova
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
V. V. Anisimov
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
M. L. Gelfond
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
M. Yu. Myasnyankin
SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
A. V. Novick
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SPBGPMA of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
T. L. Nekhayeva
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
I. A. Balduyeva
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
I. G. Gafton
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Gafton G.I., Semiletova Yu.V., Anisimov V.V., Gelfond M.L., Myasnyankin M.Yu., Novick A.V., Nekhayeva T.L., Balduyeva I.A., Gafton I.G. Photodynamic therapy in surgical treatment of patients by a skin melanom. Siberian journal of oncology. 2013;(4):23-27. (In Russ.)
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