Photodynamic therapy in surgical treatment of patients by a skin melanom
Abstract
In experimental and clinical research carried out studying of influence of neoadjyuvant photodynamic therapy on T- and B-cellular immune answer in surgical treatment of patients of a melanoma of skin of the I–III stage. PDT was executed to 25 patients two days prior to surgical removal of primary tumor from July, 2012 to January, 2013. As a result of the conducted research it was revealed that: the increase in concentration fotoditaziny doesn‘t lead to increase in quantity of tumoral cages at stages early apoptosis; lengthening of time of an exposition leads to increase in a share of late forms apoptosis, and FDT use with fotoditaziny in a dose of 50,0 mg with the subsequent radiation (662 nanometers, 400 J) in 2 days prior to surgical intervention promotes T- and B-cellular link of immune system.
About the Authors
G. I. Gafton
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
Yu. V. Semiletova
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
V. V. Anisimov
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
M. L. Gelfond
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
M. Yu. Myasnyankin
SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
A. V. Novick
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SPBGPMA of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
T. L. Nekhayeva
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
I. A. Balduyeva
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg, SZGMU of I.I. Mechnikov of Ministry of Health of Russia, St. Petersburg
Russian Federation
Russian Federation
I. G. Gafton
N.N. Petrov Oncology scientific research institute of Ministry Health of Russia, St. Petersburg
Russian Federation
Russian Federation
References
1. Балдуева И.А. Иммунологические особенности взаимоотношения опухоли и организма при меланоме // Практическая онкология. 2001. № 4 (8). С. 37–41.
2. Васильев Н.Е. Иммунологические аспекты фотодинамической терапии // Материалы научно-практической конф. «Применение полупроводниковых лазеров в медицине». СПб., 2006. С. 62.
3. Гейниц А.В., Сорокатый А.Е., Ягудаев Д.М., Трухманов Р.С. Фотодинамическая терапия. История создания метода и ее механизмы // Лазерная медицина. 2007. Т. 11, вып. 3. С. 42–46.
4. Гельфонд М.Л., Арсеньев А.И., Барчук А.С. Фотодинамическая терапия с Фотодитазином в комбинированном лечении трахеобронхиального рака и рака пищевода // Российский биотерапевтический журнал. 2004. Т. 3, № 2. С. 49–50.
5. Красновский А.А. Фотодинамическое действие и синглетный кислород // Биофизика. 2004. Т. 49, № 2. С. 305–321.
6. Филоненко Е.В., Вашакмадзе Л.А., Кириллов Н.В., Хомяков В.М. Интраоперационная фотодинамическая терапия в хирургическом лечении рака желудка. (Обзор литературы) // Сибирский онкологический журнал. 2012. № 2 (50). С. 84–89.
7. Bracketta C.M., Gollnick S.O. Photodynamic Therapy Enhancement of Anti-Tumor // Immunity Photochem. Photobiol. Sci. 2011. Vol. 10 (5). P. 649–652.
8. Dougherty T.J., Gomer C.J., Henderson B.W. et al. Photodynamic therapy // J. Natl. Cancer Inst. 1998. Vol. 90. P. 889–905.
9. Foroulis C.N., Thorpe J.A. Photodynamic therapy (PDT) in Barrett’s esophagus with dysplasia or early cancer // J. Cardiothorac Surg. 2006. Vol. 29 (1). P. 30–34.
10. Gollnick S.O., Brackett C.M. Enhancement of anti-tumor immunity by photodynamic therapy // Immunol. Res. 2010. Vol. 46 (l–3). P. 216–226.
11. Gross S.A., Wolfsen H.C. The role of photodynamic therapy in the esophagus // Gastrointest. Endosc. Clin. N. Am. 2010. Vol. 20 (1). P. 35–53.
12. Huang Z., Xu H., Meyers A.D. et al. Photodynamic therapy for treatment of solid tumors- potential and technical challenges // Technol. Cancer Res. Treat. 2008. Vol. 7 (4). P. 309–320.
13. Mroz P., Szokalska A., Wu M.X., Hamblin M.R. Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response // PLoS ONE. 2010. Vol. 5 (12). P. 151–194.
14. Preise D., Scherz A., Salomon Y. Antitumor immunity promoted by vascular occluding therapy: lessons from vascular-targeted photodynamic therapy (VTP) // Photochem. Photobiol. Sci. 2011. Vol. 10 (5). P. 681–688.
Review
For citations:
Gafton G.I., Semiletova Yu.V., Anisimov V.V., Gelfond M.L., Myasnyankin M.Yu., Novick A.V., Nekhayeva T.L., Balduyeva I.A., Gafton I.G. Photodynamic therapy in surgical treatment of patients by a skin melanom. Siberian journal of oncology. 2013;(4):23-27. (In Russ.)
Views:
576
Email this article 
