efficacy of local hyperthermia in chemotherapy and /or radiation therapy for recurrences of hodgkin’s lymphom
Abstract
Results of local hyperthermia (LHT) in combined modality treatment of 25 patients with chemo-and radio-resistant recurrences of Hodgkin’s lymphoma were analyzed. Local hyperthermia for superficial tumors was combined with chemotherapy, radiotherapy and chemoradiotherapy (41.5–42.6°С for 40–60 min.) Radiation therapy was given in daily fractions of 2 Gy or daily dose was split into 2 fractions of 1 Gy + 1 Gy to a total dose of 20–30 Gy. At 4–6 month follow-up, complete tumor response was observed in 65.0 % of cases, partial response in 15.0 % and disease progression in 20.0 %. At a follow-up of 12–30 months after completion of thermochemotherapy, local control was 16.7 % and at a follow-up of 30–60 months after completion of thermoradiotherapy, local control was 35.4 %. Accordingly, local hyperthermia improves short-and long-term results (local control) of radiotherapy and chemotherapy in patients with chemo-and radio-resistant recurrences of Hodgkin’s lymphoma.
About the Authors
O. K. Kurpeshev
Medical Radiological Research Center RAMS, Obninsk
Russian Federation
Russian Federation
V. V. Pavlov
Medical Radiological Research Center RAMS, Obninsk
Russian Federation
Russian Federation
S. S. Shklyaev
Medical Radiological Research Center RAMS, Obninsk
Russian Federation
Russian Federation
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Review
For citations:
Kurpeshev O.K., Pavlov V.V., Shklyaev S.S. efficacy of local hyperthermia in chemotherapy and /or radiation therapy for recurrences of hodgkin’s lymphom. Siberian journal of oncology. 2013;(4):28-30. (In Russ.)
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