COMPARATIVE ANALYSIS OF QUANTITATIVE COMPUTED TOMOGRAPHY DATA AND HISTOLOGICAL FINDINGS IN PATIENTS WITH GIANT CELL BONE TUMOR TREATED WITH DENOSUMAB
https://doi.org/10.21294/1814-4861-2021-20-2-22-28
Abstract
Background. Giant cell tumor of bone (GCTB) is a common benign lesion accounting for 4–9.5 % of all primary bone tumors. Although surgery is considered the method of choice in the treatment of GCT, however, denosumab, a genetically engineered drug with a novel mechanism of action, has been recently used to treat GCTB. Histological examination of a surgical specimen is undoubtedly the most objective method for assessing the effectiveness of the treatment. However, in some cases it is necessary to assess the effectiveness of conservative therapy at the stages of its implementation.
The purpose of the study was to compare CT-densitometry findings with histological findings in GCTB patients treated with denosumab.
Material and Methods. The study included 30 patients aged from 28 to 59 years with histologically verified GCTB, who received targeted therapy with denosumab followed by surgery. The changes in tumor structure during denosumab therapy and surgical specimens of the tumor were assessed.
Results. The relationship between the CT-densitometry findings and histopathological findings of surgical specimens was revealed in GCTB patients treated with denosumab.
Conclusion. CT-densitometry findings were shown can be used to
predict pathological response of the tumor to denosumab treatment.
About the Authors
S. A. Tabakaev
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, Junior Researcher, Department of Radiation Imaging Department
Author ID (Scopus): 89609295899
5, Kooperativny Street, 634009, Tomsk, Russia
I. G. Frolova
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, DSc, Professor, Head of Imaging Department
Author ID (Scopus): 700641170. Researcher ID (WOS): С-8212-2012
5, Kooperativny Street, 634009, Tomsk, Russia
I. I. Anisenya
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, PhD, Senior Researcher
Researcher ID (WOS): D-8434-2012. Author ID (Scopus): 6507640381
5, Kooperativny Street, 634009, Tomsk, Russia
N. V. Vasilyev
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, PhD, Senior Researcher, Department of General and Molecular Pathology
Researcher ID (WOS): D-1144-2012. Author ID (Scopus): 57192110276
5, Kooperativny Street, 634009, Tomsk, Russia
A. V. Bogoutdinova
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, PhD, Oncologist, Department of General Oncology
5, Kooperativny Street, 634009, Tomsk, Russia
P. K. Sitnikov
Cancer Research Institute. Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
MD, Oncologist, Department of General Oncology
5, Kooperativny Street, 634009, Tomsk, Russia
References
1. Huh A., Villelli N., Martinez D., Ting J., Birhiray R., Payner T.D., Kulwin C.G. Denosumab Treatment for a Residual Giant Cell Tumor of the Clivus: A Case Report and Review of the Literature. World Neurosurg. 2018 Oct; 118: 98–101. doi: 10.1016/j.wneu.2018.06.242.
2. Bachini P., Bertoni F., Boulytcheva I. Differential diagnosis of giant cell-containing bone lesions. Sarcomas of bones, soft tissues and skin tumors. 2013; 3: 31–38.
3. Oktay K., Guzel E., Simsek S., Guzel A. Giant cell tumor of the eleventh thoracic vertebra in a pediatric patient: an interesting case report and comprehensive literature review. Childs Nerv Syst. 2019 Mar; 35(3): 553–557. doi: 10.1007/s00381-018-3980-x.
4. Dianov S.V. Adjuvant cryotherapy in the surgical treatment of giant cell bone tumor. Traumatology and Orthopedics of Russia. 2018; 24(1): 8–17. (in Russian). doi: 10.21823/2311-2905-2018-24-1-8-17.
5. Amanatullah D.F., Clark T.R., Lopez M.J., Borys D., Tamurian R.M. Giant cell tumor of bone. Orthopedics. 2014 Feb; 37(2): 112–20. doi: 10.3928/01477447-20140124-08.
6. Balberkin A.K.1, Shavirin D.A. Clinics, diagnostic and surgical treatment of tumors of bones, forming knee joint (literature review). Sarcomas of Bones, Soft Tissues and Skin Tumors. 2013; (1): 15–23. (in Russian).
7. Tikhilov R.M., Ptashnikov D.A., Mikailov I.M., Zasulsky F.Yu., Grigoryev P.V. Surgical treatment for giant cell tumor of the bones. P.A. Herzen Journal of Oncology. 2017; 6(1): 5–11. (in Russian). doi: 10.17116/onkolog2017615-11.
8. Tojibayev A., Gafur-Akhunov M. Optimization of surgical treatment methods of giant cell tumor of long bones. Eurasian Journal of Oncology. 2015; 4(7): 52–59. (in Russian).
9. Terskov A.Iu., Ivanov V.V., Nikolaenko A.N. Our tactics in diagnostics and treatment of patients with giant-cell tumors of bones. Genij Ortopedii. 2013; (2): 67–71. (in Russian).
10. Dydykina P.S., Petrova E.V., Dydykina I.S., Smirnov A.V., Muravyev Yu.V., Glukhova S.I., Nasonov E.L. Changes of clinical and radiographic parameters during denosumab therapy in rheumatoid arthritis patients receiving glucocorticoids: preliminary results. Rheumatology Science and Practice. 2015; 53(4): 397–402. (in Russian). doi: 10.14412/1995-4484-2015-397-402.
11. Gershtein E.S., Timofeev Yu.S., Zuev A.A., Kushlinskii N.E. RANK/RANKL/OPG ligand-receptor system and its role in primary bone neoplasms (literature analysis and own data). Advances in Molecular Oncology. 2015; 3(2): 51–59. (in Russian). doi: 10.17650/2313-805X-2015-2-3-51-59.
12. Manzyuk L.V., Bagrova S.G., Kopp M.V., Kutukova S.I., Semiglazova T.Yu. The use of osteomodifying agents for the prevention and treatment of bone tissue pathology in malignant neoplasms. Malignant Tumors: Practical Recommendations from RUSSCO. 2017; 7: 3s2: 477–485. (in Russian).
13. Huvos A.G., Rosen G., Marcove R.C. Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement. Arch Pathol Lab Med. 1977 Jan; 101(1): 14–8.
Review
For citations:
Tabakaev S.A., Frolova I.G., Anisenya I.I., Vasilyev N.V., Bogoutdinova A.V., Sitnikov P.K. COMPARATIVE ANALYSIS OF QUANTITATIVE COMPUTED TOMOGRAPHY DATA AND HISTOLOGICAL FINDINGS IN PATIENTS WITH GIANT CELL BONE TUMOR TREATED WITH DENOSUMAB. Siberian journal of oncology. 2021;20(2):22-28. (In Russ.) https://doi.org/10.21294/1814-4861-2021-20-2-22-28
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