NEUTRON RADIATION THERAPY IN THE TREATMENT OF RECURRENT HIGH-GRADE GLIOMA
M. M. Sarycheva,
A. V. Vazhenin,
E. Ya. Mozerova,
A. A. Lozhkov,
R. Yu. Karabut,
A. Yu. Maksimovskaya,
D. M. Timokhina,
Zh. E. Sabelnikova https://doi.org/10.21294/1814-4861-2021-20-2-77-84
Abstract
The main objective of this study was to determine the place and role of neutron radiation therapy in the treatment of patients with recurrent high-grade glioma.
Material and Methods. Treatment outcomes were analyzed in 40 patients who were treated at Oncology Center (Chelyabinsk) and Center for Neutron Therapy (Snezhinsk) from 2005 to 2015. The median age of patients was 45 years. The male to female ratio was 1:1. Recurrent glioblastoma was diagnosed in 19 patients, and anaplastic astrocytoma was revealed in 21 patients. Twenty patients underwent neutron therapy alone,and 20 patients underwent combined neutronphoton radiation therapy. The median overall survival time for all patients with recurrent high-grade glioma was 50 months. The 1-year, 2-year and 3-year survival rates were 94.1 %, 77.8 % and 66.7 % respectively.
Results. The median survival time after treatment for relapse was 27 months. The main prognostic factors affecting the treatment outcomes were the age of the patients, histological verification and time to relapse. The method-specific overall survival rate was significantly higher in patients who underwent combined neutron-photon radiation therapy than in patients who underwent neutron therapy alone (48 months versus 20 months, p=0.05).
About the Authors
M. M. Sarycheva
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine;
South Ural State Medical University, department of Oncology, Radiology and Radiotherapy
Russian Federation
Russian Federation
MD, Radiotherapist; Assistant, Department of Oncology, Radiation Diagnostics and Radiation Therapy
42, Blucher Street, 454000, Chelyabinsk, Russia
64, Vorovskogo Street, 454000, Chelyabinsk, Russia
A. V. Vazhenin
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine;
South Ural State Medical University, department of Oncology, Radiology and Radiotherapy
Russian Federation
Russian Federation
MD, Professor, Member of the Russian Academy of Sciences, Head of the Department of Oncology, Radiation Diagnostics and Radiation Therapy; Head Physician
42, Blucher Street, 454000, Chelyabinsk, Russia
64, Vorovskogo Street, 454000, Chelyabinsk, Russia
E. Ya. Mozerova
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine;
South Ural State Medical University, department of Oncology, Radiology and Radiotherapy
Russian Federation
Russian Federation
MD, PhD, Radiotherapist; Assistant of the Department of Oncology, Radiation Diagnostics and Radiation Therapy
42, Blucher Street, 454000, Chelyabinsk, Russia
64, Vorovskogo Street, 454000, Chelyabinsk, Russia
A. A. Lozhkov
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
MD, Radiotherapist
ORCID: 0000-0001-6385-807
42, Blucher Street, 454000, Chelyabinsk, Russia
R. Yu. Karabut
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
MD, Radiotherapist
42, Blucher Street, 454000, Chelyabinsk, Russia
A. Yu. Maksimovskaya
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
MD, Radiotherapist
42, Blucher Street, 454000, Chelyabinsk, Russia
D. M. Timokhina
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
MD, Radiotherapist
42, Blucher Street, 454000, Chelyabinsk, Russia
Zh. E. Sabelnikova
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
MD, Radiotherapist
42, Blucher Street, 454000, Chelyabinsk, Russia
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Review
For citations:
Sarycheva M.M., Vazhenin A.V., Mozerova E.Ya., Lozhkov A.A., Karabut R.Yu., Maksimovskaya A.Yu., Timokhina D.M., Sabelnikova Zh.E. NEUTRON RADIATION THERAPY IN THE TREATMENT OF RECURRENT HIGH-GRADE GLIOMA. Siberian journal of oncology. 2021;20(2):77-84. (In Russ.) https://doi.org/10.21294/1814-4861-2021-20-2-77-84
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