MALIGNANT TUMORS OF BONES. MORBIDITY, MORTALITY, INDEX ACCURACY, SURVIVAL OF PATIENTS ACCORDING TO HISTOLOGICAL FORMS

Introduction. Standardized (world standard) incidence of malignant tumors of bones (S40,41) does not have has significant fluctuations. According to IARC among male population the most common incidence rates range from 1 to 2 cases per 100.000 and among female population – from 0.5 to 1.0 among women.  Purpose of study. To study dynamics of morbidity and mortality from malignant tumors of bones, the quality of estimation, observed and relative survival of patients according to histological forms. The work of this level is held in Russia for the first time. Material and methods of study. There were used an open world and domestic sources to estimate the prevalence of malignant tumors of bones, databases of population-based cancer registers, classical methods of population-based estimation of the prevalence of malignant tumors of bones. results of study. The basis of this work is data from the Population-based Cancer Registry of St. Petersburg and special studies being held before its establishing in 1993. Annually in St. Petersburg there are registered 40–60 primary cases of malignant tumors of bones (S40, 41). The level of morphological verification of these malignancies in Russia is 82.1 %, in St. Petersburg – 84.9 %. There is a high rate of undefined stage: in Russia – 19.7 %, in St. Petersburg – 24.5 %, in Moscow – 23.5 %. During the first year of observation 27.3 % of patients die in Russia, 21.7 % in St. Petersburg, and 11.1 % in Moscow. In comparison with the average data (Eurocare program) the relative survival of patients in St. Petersburg is significantly lower: in men (St. Petersburg – 42.2–48.2 %, (Eurocare-3,4 – 55–58 %), in women (St. Petersburg – 32.2–54.6 % (Eurocare – 59–63 %). conclusion. Thus, in this work for the first time in Russia it is showed dynamics of absolute and relative incidence rates of malignant tumors of bones since 1980 by sex and age-specific indicators. It is presented a set of analytical indicators, the level of morphological verification, one-year mortality as well as observed and relative survival. For the first time it is provided dynamics of a 5-year survival of patients with malignant tumors of bone in accordance with the histological forms. There is marked a growth of a 5-year survival rates of patients with chondrosarcoma and osteosarcoma.

malignant tumors of bones, incidence, mortality, index accuracy, survival, histology

1. Malignancies in Leningrad / Ed. R.I. Vagner. L., 1991. 158 p. [in Russian]

2. Malignant tumors in Russia in 2013 (morbidity andRussian]

3. Ivanov O.A., Sukharev A.E., Starinskiy V.V., Egorov S.N. Processing method database (survival): methodical recommendations. M., 1997. 32 p. [in Russian]

4. Merabishvili V.M. The survival of cancer patients. SPb., 2006. 440 p. [in Russian]

5. Merabishvili V.M. Survival of cancer patients / Ed. Yu.A. Shcherbuk. SPb., 2011. Issue 2. Part 1. 332 p. [in Russian]

6. Merabishvili V.M. Survival of cancer patients / Ed. Yu.A. Shcherbuk. SPb., 2011. Issue 2. Part 2. 408 p. [in Russian]

7. Merabishvili V.M. Cancer control in St. Petersburg (operative report for 2011–2012, precise elaboration of registry`s data base in accordance with internationals standarts). Population-based Cancer Registry (IACR № 221) Sci publ. / Ed. V. M. Kolabutin, A.M. Belyaev. SPb., 2013. № 18. 368 p. [in Russian]

8. Merabishvili V.M. Oncological Statistics (traditional methods, new information technologies). Guidelines for physicians. SPb., 2011. Part I. 224 p. [in Russian]

9. Merabishvili V.M. Oncological Statistics (traditional methods, new information technologies). Guidelines for physicians. SPb., Part II. 248 p. [in Russian]

10. Organization and operation of the population cancer registry: Methodical recommendations / Eds. V.V. Starinskiy, V.M. Merabishvili, O.P. Gretsova et al. M., 2001. 13 p. [in Russian]

11. The basic principles of selection and coding underlying cause of death in patients with malignant tumors: Methodical recommendations / Eds. V.V. Starinskiy. M., 2002. 37 p. [in Russian]

12. Starinskiy V.V., Petrova G.V., Gretsova O.P., Kharchenko N.V., Merabishvili V.M. Improving the forms of federal statistical reporting on oncology // Povolozhskiy onkologicheskiy vestnik. 2001. № 1. P. 88–89. [in Russian]

13. Cancer incidence in five continents. Vol. I–IX. URL : http://www. ci5.iarc.fr/C151-IX/C15i-ix.htm (25.02.2015).

14. Gl oboc an – 2012 URL:http://www.globocan.iarc.fr(25.02.2015).

15. Richards M. Eurocare 4 studies bring new data of cancer survival // Lancet oncology. 2007. Vol. 8 (9). P. 752–753.

16. Survay of Cancer patients in Europe: the Eurocare-3 Study / Ed. F. Berrino et al. // Ann. Oncol. 2003. Vol. 14. Suppl. 5.

17. Survival of cancer patients in Europe / Ed. F. Berrino et al. IARC Sci. publ. № 132. Lyon, 1995. 465 p.

18. Survival of cancer patients in Europe: the Eurocare-2 Study / Ed. F. Berrino et al. IARC Sci. publ. № 151. Lyon, 1999. 572 p.

19. Verdecchia A., Francisci S., Brenner H., Gatta G., Micheli A., Mangone L., Kunkler I. Recent cancer survival in Europe: a 2000–2002 period analysis of Eurocare-4 data // Lancet oncol. 2007. Vol. 8 (9). P. 784–796.