PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS
Abstract
Currently, there is a marked tendency towards improvement of early detection of breast cancer that allows patients at extremely low risk for developing recurrent disease to be identified. Therefore, it is necessary to search for biological markers of unfavorable prognosis for patients with hormone-dependent breast cancer. In order to introduce these markers into routine clinical practice, they should be validated in welldesigned clinical studies, provide additional predictive information and be easily reproducible. The standard immunohistochemical parameters (estrogen and progesterone receptors and Ki67 cell proliferation index) can be served as these markers. However, the dynamic changes in these parameters during hormone therapyrather than their initial expression levels in the tumor are of great significance for the individualized hormone therapy.
About the Authors
M. V. Rodionova
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Rodionova Maria Valerievna, postgraduate, Department of Breast Tumor Surgery.
E-mail: miss.rodionova@gmail.com. SPIN-code: 8186-9358
I. K. Vorotnikov
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Vorotnikov Igor Konstantinovich, MD, Professor, Head of Department of Breast Tumor Surgery.
E-mail: i.vorotnikov@mail.ru
V. V. Rodionov
Ulyanovsk State University
Russian Federation
Russian Federation
Rodionov Valery Vitalievich, Professor, Head of Surgical Department № 2.
E-mail: dr.valery.rodionov@gmail.com
E. A. Dudko
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Dudko Evgeny Alexandrovich, PhD, Senior Researcher, Laboratory of Medical Chemistry.
E-mail: e.a.dudko@gmail.com. SPIN-code: 3046-5833
N. V. Chkhivadze
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Chkhvadze Nino Valerianovna, MD, PhD, Department of Breast Tumor Surgery.
E-mail: nchkhi@gmail.com
V. V. Kometova
Ulyanovsk State University
Russian Federation
Russian Federation
Kometova Vlada Vladimirovna, MD, PhD, pathologist, Department of Anatomic Pathology.
E-mail: vladastasiatema@mail.ru. SPIN-code: 2390-4253
D. A. Ryabchikov
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Ryabchikov Denis Anatolievich, MD, PhD, Senior Researcher, Department of Breast Tumor Surgery.
E-mail: dr.denisr@mail.ru
E. V. Oshkina
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Oshkina Elena Viktorovna, Researcher, Department of Epidemiology and Cancer Prevention.
E-mail: elen.oshkina@yandex.ru
A. S. Ozherelyev
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Ozherelyev Alexandr Svyatoslavovich, Professor, Principal Researcher, Surgery Department.
E-mail: labmedchem@mail.ru
T. А. Bogush
N.N. Blokhin Russian Cancer Research Center, Moscow
Russian Federation
Russian Federation
Bogush Tatiana Anatolievna, Professor, Head of Medical Chemistry Laboratory.
E-mail: bogush@orc.ru. SPIN-code: 4050-0061
References
1. Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists’ Group, Forbes J.F., Cuzick J., Buzdar A., Howell A., Tobias J.S., Baum M. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial // Lancet Oncol. 2008. Vol. 9 (1). P. 45–53.
2. Bullwinkel J., Baron-Lühr B., Lüdemann A., Wohlenberg C., Gerdes J., Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells // J. Cell Physiol. 2006. Vol. 206 (3). P. 624–635.
3. Chang J., Powles T.J., Allred D.C., Ashley S.E., Makris A., Gregory R.K., Osborne C.K., Dowsett M. Prediction of clinical outcome from primary tamoxifen by expression of biologic markers in breast cancer patients // Clin. Cancer Res. 2000. Vol. 6 (2). P. 616–621.
4. Cuzick J., Dowsett M., Pineda S., Wale C., Salter J., Quinn E., Zabaglo L., Mallon E., Green A.R., Ellis I.O., Howell A., Buzdar A.U., Forbes J.F. Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer // J. Clin. Oncol. 2011. Vol. 29 (32). P. 4273–4278. doi: 10.1200/JCO.2010.31.2835.
5. Dowsett M., Smith I., Robertson J., Robison L., Pinhel I., Johnson L., Salter J., Dunbier A., Anderson H., Ghazoui Z., Skene T., Evans A., A’Hern R., Iskender A., Wilcox M., Bliss J. Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer // J. Natl. Cancer Inst. Monogr. 2011. Vol. 2011 (43). P. 120–123. doi: 10.1093/jncimonographs/lgr034.
6. Dowsett M., Smith I.E., Ebbs S.R., Dixon J.M., Skene A., Griffith C., Boeddinghaus I., Salter J., Detre S., Hills M., Ashley S., Francis S., Walsh G.; IMPACT Trialists. Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival // Clin. Cancer Res. 2005. Vol. 11 (2 Pt 2). 951s–958s.
7. Eiermann W., Paepke S., Appfelstaedt J., Llombart-Cussac A., Eremin J., Vinholes J., Mauriac L., Ellis M., Lassus M., Chaudri-Ross H.A., Dugan M., Borgs M.; Letrozole Neo-Adjuvant Breast Cancer Study Group. Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study // Ann. Oncol. 2001. Vol. 12 (11). P. 1527–1532.
8. Ellis M.J., Coop A., Singh B., Mauriac L., Llombert-Cussac A., Jänicke F., Miller W.R., Evans D.B., Dugan M., Brady C., Quebe-Fehling E., Borgs M. Letrozole is more effective neoadjuvant endocrine chemotherapy than tamoxifen for ErbB-1and/or ErbB-2-positive, estrogen receptorpositive primary breast cancer: evidence from a phase III randomized trial // J. Clin. Oncol. 2001. Vol. 19 (18). P. 3808–3816.
9. Ellis M.J., Tao Y., Luo J., A’Hern R., Evans D.B., Bhatnagar A.S., Chaudri Ross H.A., von Kameke A., Miller W.R., Smith I., Eiermann W., Dowsett M. Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics // J. Natl. Cancer Inst. 2008. Vol. 100 (19). P. 1380–1388. doi: 10.1093/jnci/djn309.
10. Fayanju O.M., Nwaogu I., Jeffe D.B., Margenthaler J.A. Pathological complete response in breast cancer patients following neoadjuvant chemotherapy at a Comprehensive Cancer Center: The natural history of elusive prognosticator // Mol. Clin. Oncol. 2015. Vol. 3. P. 775–780.
11. Gil M.J., Barnadas A., Cirera L., Tusquets I., Muñoz M., Arcusa A., Prieto L., Moreno A., Graupera J., Margeli M. Primary hormonal therapy with exemestane in patients with breast tumors >3 cm in diameter: Results of a Spanish multicenter phase II trial // J. Clin. Oncol. 2004. Vol. 22 (14S). P. 603.
12. Goldhirsch A., Winer E.P., Coates A.S., Gelber R.D., PiccartGebhart M., Thürlimann B., Senn H.J.; Panel members. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 // Ann. Oncol. 2013. Vol. 24 9. P. 2206–2223. doi: 10.1093/annonc/mdt303.
13. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation // Cell. 2011. Vol. 144 (5). P. 646–674. doi: 10.1016/j.cell.2011.02.013.
14. Howell A., Harland R.N., Barnes D.M., Baildam A.D., Wilkinson M.J., Hayward E., Swindell R., Sellwood R.A. Endocrine therapy for advanced carcinoma of the breast: relationship between the effect of tamoxifen upon concentrations of progesterone receptor and subsequent response to treatment // Cancer Res. 1987. Vol. 47 (1). P. 300–304.
15. Makris A., Powles T., Allred D.C., Ashley S., Ormerod M.G., Titley J.C., Dowsett M. Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response // Breast Cancer Res. Treat. 1998. Vol. 48 (1). P. 11–20.
16. Romero Q., Bendahl P.-O., Ferno M., Grabau D., Borgquist S. A novel model for Ki67 assessment in breast cancer // Diagnostic pathology. 2014. Vol. 9. P. 118. doi: 10.1186/1746-1596-9-118.
17. Rossi L., Stevens D., Pierga J., Lerebours F., Reyal F., Robain M., Asselain B., Rouzier R. Impact of Adjuvant Chemotherapy on Breast Cancer Survival: A Real-World Population // PloS. One. 2015. Vol. 10 (7): e0132853. doi: 10.1371/journal.pone.0132853.
18. Sachelarie I., Grossbard M.L., Chadha M., Feldman S., Ghesani M., Blum R.H. Primary Systemic Therapy of Breast Cancer // The Oncologist. 2006. Vol. 11 (6). P. 574–589.
19. Semiglazov V.F., Semiglazov V.V., Ivanov V.G., Bozhok A., Ziltzova E.K., Paltuev R.M., Dashian G.A., Kletzel A., Topuzov E.E., Berstein L. The relative efficacy of neoadjuvant endocrine therapy versus chemotherapy in postmenopausal women with ER-positive breast cancer // J. Clin. Oncol. 2004. Vol. 22 (14S). P. 519.
20. Von Minckwitz G., Untch M., Blohmer J.U., Costa S.D., Eidtmann H., Fasching P.A., Gerber B., Eiermann W., Hilfrich J., Huober J., Jackisch C., Kaufmann M., Konecny G.E., Denkert C., Nekljudova V., Mehta K., Loibl S. Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes // J. Clin. Oncol. 2012. Vol. 30 (15). P. 1796–1804. doi: 10.1200/JCO.2011.38.8595.
21. Witteveen A., Vliegen I.M., Sonke G.S., Klaase J.M., IJzerman M.J., Siesling S. Personalisation of breast cancer follow-up: a time-dependent prognostic nomogram for the estimation of annual risk of locoregional recurrence in early breast cancer patients // Breast Cancer Res. Treat. 2015. Vol. 152 (3). P. 627–636. doi: 10.1007/s10549-015-3490-4.
Review
For citations:
Rodionova M.V., Vorotnikov I.K., Rodionov V.V., Dudko E.A., Chkhivadze N.V., Kometova V.V., Ryabchikov D.A., Oshkina E.V., Ozherelyev A.S., Bogush T.А. PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS. Siberian journal of oncology. 2015;1(5):102-109. (In Russ.)
Views:
1070
Email this article 
