BREAST-CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS
https://doi.org/10.21294/1814-4861-2021-20-4-116-121
Abstract
The purpose of the study was to present the most recent data on the outcomes of breast-conserving surgery after neoadjuvant chemotherapy for breast cancer patients.
Material and methods. We analyzed relevant publications available in the pubmed, cochrane library, e-library databases between 1990 and 2020, and 24 of them were used to write this review.
Results. Neoadjuvant chemotherapy for breast cancer patients is currently a widespread treatment option. The main advantage of this type of treatment for patients with early stage breast cancer is the feasibility of performing breast-conserving surgery in cases of partial or complete clinical response and, therefore, the improvement of the quality of life of patients with equivalent rates of disease-free survival compared to radical mastectomies.
Conclusion. Numerous studies have shown that breast-conserving surgery following neoadjuvant chemotherapy is the safe surgery with good oncologic outcomes and an alternative to radical mastectomies in breast cancer patients. However, further studies are required to determine the optimal safe resection margin width in patients with complete and partial responses to neoadjuvant chemotherapy.
About the Authors
A. R. Bosieva
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, PhD, Researcher, Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin
3, 2nd Botkinsky Passage, 125284, Moscow, Russia
M. V. Ermoshchenkova
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation;
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
MD, PhD, Researcher, Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin; Assistant Professor
3, 2nd Botkinsky Passage, 125284, Moscow, Russia
8/2, Trubetskaya Street, 119991, Moscow, Russia
N. N. Volchenko
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, Head of Oncomorphology Department
3, 2nd Botkinsky Passage, 125284, Moscow, Russia
A. D. Zikiryahodjaev
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation;
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
MD, DSc, Head of the Department of Oncology and Reconstructive Plastic Surgery of the Breast and Skin; Assistant Professor
3, 2nd Botkinsky Passage, 125284, Moscow, Russia
8/2, Trubetskaya Street, 119991, Moscow, Russia
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Review
For citations:
Bosieva A.R., Ermoshchenkova M.V., Volchenko N.N., Zikiryahodjaev A.D. BREAST-CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS. Siberian journal of oncology. 2021;20(4):116-121. (In Russ.) https://doi.org/10.21294/1814-4861-2021-20-4-116-121
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