TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS
Abstract
Twenty-six cases with secondary malignant tumors in children and adolescents receiving treatment for Hodgkin’s lymphoma and acute lymphoblastic leukemia were analyzed. In all cases the lesion had developed in an area of previous radiation treatment. The interval between the primary treatment and secondary cancer development was from 3 to 29 years. The radiation therapy dose was from 12 to 45 Gy. Treatment of secondary cancer was successful only in 5 patients, the remaining patients died of disease progression. The risk of developing secondary cancer should be considered when planning treatment for patients with hemoblastosis. In cases with favorable prognosis (complete remission after induction chemotherapy and other signs of favorable prognosis) it is advisable to withhold radiation therapy as the most important risk factor for cancer.
About the Authors
O. I. Scherbenko
Russian Scientific Center of Roentgenoradiology, Moscow
Russian Federation
Russian Federation
R. A. Parkhomenko
Russian Scientific Center of Roentgenoradiology, Moscow
Russian Federation
Russian Federation
References
1. Agha A., Sherlock M., Brennan S. at al. Hypothalamic-Pituitary Dysfunction after irradiation of nonpituitary brain tumors in adults // J. Clin. Endocrinol. Metabolism. 2005. Vol. 90 (12). P. 6355.
2. Alison M.R., Lin W.R., Lim S.M. et al. Cancer stem cells: in the line of fire // Cancer Treat. Rev. 2012. Vol. 38 (6). P. 589–598.
3. Asai A., Kawamoto K. Radiation-induced brain injury // Brain Nerve. 2008. Vol. 6 (2). P. 123–129.
4. Armstrong G.T., Robison L.L., Liu W. et al. Occurrence of Multiple Subsequent Neoplasms in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study // Eur. J. Cancer. 2003. Vol. 39 (16). P. 2379–2386.
5. Armstrong G.T., Stovall M., Robison L.L. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study // Radiat. Res. 2010. Vol. 174 (6). P. 840–850.
6. Armstrong G.T., Yasui Y., Huang S. et al. Long-term outcomes among survivors of childhood central nervous system malignancies in the childhood cancer survivor study // J. Natl. Cancer Inst. 2009. Vol. 101 (13). P. 946–958.
7. Anderson N.E. Late complications in childhood central nervous system tumor survivors // Curr. Opin. Neurol. 2003. Vol. 16 (6). P. 677–683.
8. Asai A., Matsutni M., Matsuda T. at al. Radiation-induced brain atrophy // Gan No Rinsho. 1989. Vol. 35 (11). P. 1325–1329.
9. Barbaro P.M., Johnston K., Dalla-Pozza L. et al. Reduced incidence of second solid tumors in survivors of childhood Hodgkin’s lymphoma treated without radiation therapy // Ann. Oncol. 2011. Vol. 22 (12). P. 2569–2574.
10. Brunner T.B., Kunz-Schughart L.A., Grosse-Gehling P. et al. Cancer stem cells as a predictive factor in radiotherapy // Semin. Radiat. Oncol. 2012. Vol. 22 (2). P. 151–174.
11. Castellino S.M., Geiger A.M., Mertens A.C. et al. Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study // Blood. 2011. Vol. 117 (6). P. 1806–1816.
12. Friedman D.L., Whitton J., Leisenring W. et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study // J. Natl. Cancer Inst. 2010. Vol. 102 (14). P. 1083–1095.
13. Henderson T.O., Oeffinger K.C., Whitton J. et al. Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study // Ann. Intern. Med. 2012. Vol. 156 (11). P. 757–766.
14. Galloway T.J., Indelicato D.J., Amdur R.J. et al. Second tumors in pediatric patients treated with radiotherapy to the central nervous system // Am. J. Clin. Oncol. 2012. Vol. 35 (3). P. 279–283.
15. Grotenhuis B.A., Wijnhoven B.P., van Lanschot J.J. Cancer stem cells and their potential implications for the treatment of solid tumors // J. Surg. Oncol. 2012. Vol. 106 (2). P. 209–215.
16. Koch U., Krause M., Baumann M. Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective // Semin. Cancer Biol. 2010. Vol. 20 (2). P. 116–124.
17. Metzger M.L., Weinstein H.J., Hudson M.M. et al. Association between radiotherapy vs no radiotherapy based on early response to VAMP chemotherapy and survival among children with favorable-risk Hodgkin lymphoma // JAMA. 2012. Vol. 307 (24). P. 2609–2616.
18. O'Brien M.M., Donaldson S.S., Balise R.R. et al. Second malignant neoplasms in survivors of pediatric Hodgkin’s lymphoma treated with low-dose radiation and chemotherapy // J. Clin. Oncol. 2010. Vol. 28 (7). P. 1232–1239.
19. Sun W.F., Cheng F.W., Lee V. et al. Second malignant neoplasms in childhood cancer survivors in a tertiary pediatric oncology centre in Hong Kong, China // Chin. Med. J. (Engl). 2011. Vol. 124 (22). P. 3686–3692.
20. Travis L.B., Ng A.K., Allan J.M. et al. Second malignant neoplasms and cardiovascular disease following radiotherapy // J. Natl. Cancer Inst. 2012. Vol. 104 (5). P. 357–370.
Review
For citations:
Scherbenko O.I., Parkhomenko R.A. TO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTS. Siberian journal of oncology. 2013;(4):62-65. (In Russ.)
Views:
583
Email this article 
