COMBINED MODALITY TREATMENT INCLUDING LOCAL HYPERTHERMIA IN PATIENTS WITH LOCALLY-ADVANCED LARYNGEAL AND LARYNGOPHARYNGEAL CANCER
Abstract
The paper presents two-year results of combined modality treatment of patients with stage III–IV (T3N0–1M0) locally advanced laryngeal and laryngopharyngeal cancer. In the first phase of the treatment, all 24 patients included into the study, received preoperative RT with local hyperthermia. Preventive tracheostoma was not an obstacle for the treatment. Patients who achieved partial response or stable disease underwent surgery. In case of complete tumor regression (n=5), radiotherapy was continued up to the total dose of 66 Gy. Histological examination of surgical specimens revealed complete pathological response in all patients who received combined modality treatment. Regional metastases were revealed in 2 patients, and they subsequently underwent lymph node dissection. The overall 2-year survival rate was 100 % and 2-year metastasis-free survival was 91.7 %.
About the Authors
E. L. ChoynzonovRussian Federation
Choynzonov Evgeny Lhamatsirenovich, MD, DSc, Academician of RAS, Professor, Director of the Tomsk Cancer Research Institute.
E-mail: nii@oncology.tomsk.ru. SPIN-code: 2240-8730.
M. R. Mukhamedov
Russian Federation
Muhamedov Marat Rafkatovich, MD, DSc, Leading researcher, Department head and neck tumors.
E-mail: muhamedov@oncology.tomsk.ru. SPIN-code: 6780-1498.
Zh. A. Startseva
Russian Federation
Startseva Zhanna Alexandrovna, MD, DSc, Head, Radiology Department.
E-mail: zhanna.alex@ rambler.ru. SPIN-code: 8121-0310.
I. O. Spivakova
Russian Federation
Spivakova Irina Olegovna, Postgraduat Student, Department head and neck tumors.
E-mail: irensp2005@mail.ru. SPIN-code: 5877-5820.
O. V. Cheremisina
Russian Federation
Cheremisina Olga Vladimirovna, MD, DSc, Head of Endoscopy Department.
E-mail: СheremisinaOV@oncology.tomsk.ru. SPIN-code: 9579-2691.
N. V. Vasilyev
Russian Federation
Vasilyev Nikolai Voltovich, MD, PhD, Senior Researcher, Laboratory of Pathological Anatomy and Cytology.
E-mail: vasilievasn@yandex.ru. SPIN-code: 1627-5226.
O. V. Gribova
Russian Federation
Gribova Olga Vjacheslavovna, MD, PhD, Researcher, Radiology Department.
E-mail: gribova79@mail.ru. SPIN-code: 1405-1669.
References
1. Kaprin A.D., Starinskij V.V., Petrova G.V. Cancer incidence in Russia in 2012 (morbidity and mortality). Moscow, 2014. 250 p. [in Russian]
2. Kicmanjuk Z.D., Choinzonov E.L., Musabaeva L.I., Novikov V.A. Tactics of treatment of laryngeal cancer at the present stage // Sibirskij onkologicheskij zhurnal. 2003. № 2. P. 3–11. [in Russian]
3. Mukhamedov M.R., Choinzonov E.L., Gunter V.E., Cheremisina O.V., Lukyanov V.D., Myadzel A.A., Shinkarev S.A., Korenev A.A., Vasiliev N.V., Tsvetayev V.A., Kulbakin D.E. Titanium nikcekide-based bioadapted implants in surgical rehabilitation of patients with laryngeal cancer (results of a ten-year cooperative study) // Vestnik RONC im. N. N. Blohina RAMN. 2010. Vol. 21 (1). P. 65–70. [in Russian]
4. Podvjaznikov S.O., Choinzonov E.L., Kropotov M.A., Kozhanov L.G., Pustynskij I.N., Pis’mennyj V.I., Alieva S.B., Aketova T.A., Tabolinovskaja T.D. Diagnosis and treatment of cancer of the hypopharynx. Clinical recommendations // Sibirskij onkologicheskij zhurnal. 2014. № 6. P. 71–75. [in Russian]
5. Chizhevskaya S.Yu., Choinzonov E.L., Balatskaya L.N. Quality of life in patients with laryngeal and laryngopharyngeal cancer in short-and long term follow-up // Sibirskij onkologicheskij zhurnal. 2015. № 2. P. 15–22. [in Russian]
6. Chizhevskaya S.Yu., Choinzonov E.L. Modern approaches to combined modality treatment for laryngeal and laryngopharyngeal cancers // Sibirskij onkologicheskij zhurnal. 2007. № 4. P. 127–132. [in Russian]
7. Choynzonov E.L., Startseva Zh.A., Mukhamedov M.R., Spivakova I.O., Cheremisina O.V., Gribova O.V., Kul’bakin D.E. Local hyperthermia in the combined treatment of patients with cancer of the larynx and hypopharynx // Sibirskij onkologicheskij zhurnal. 2014. № 5. P. 5–12. [in Russian]
8. Choinzonov E.L., Balatskaya L.N., Muhamedov M.R. Cancer of the larynx. Modern aspects of treatment and rehabilitation. Tomsk, 2008. 276 p. [in Russian]
9. Choinzonov E.L., Balatskaya L.N. Life quality of cancer patients. Tomsk, 2011. 152 p. [in Russian]
10. Genden E.M., Ferlito A., Rinaldo A., Silver C.E., Fagan J.J., Suárez C., Langendijk J.A., Lefebvre J.L., Bradley P.J., Leemans C.R., Chen A.Y., Jose J., Wolf G.T. Recent changes in the treatment of patients with advanced laryngeal cancer // Head Neck. 2008. Vol. 30 (1). P. 103–110.
11. Nakahara R., Kodaira T., Furutani K., Tachibana H., Tomita N., Inokuchi H., Mizoguchi N., Goto Y., Ito Y., Naganawa S. Treatment outcomes of definitive chemoradiotherapy for patients with hypopharyngeal cancer // J. Radiat. Res. 2012. Vol. 53 (6). P. 906–915. doi: 10.1093/jrr/rrs052.
Review
For citations:
Choynzonov E.L., Mukhamedov M.R., Startseva Zh.A., Spivakova I.O., Cheremisina O.V., Vasilyev N.V., Gribova O.V. COMBINED MODALITY TREATMENT INCLUDING LOCAL HYPERTHERMIA IN PATIENTS WITH LOCALLY-ADVANCED LARYNGEAL AND LARYNGOPHARYNGEAL CANCER. Siberian journal of oncology. 2015;(6):13-18. (In Russ.)