COMBINED MODALITY TREATMENT INCLUDING LOCAL HYPERTHERMIA IN PATIENTS WITH LOCALLY-ADVANCED LARYNGEAL AND LARYNGOPHARYNGEAL CANCER
Abstract
The paper presents two-year results of combined modality treatment of patients with stage III–IV (T3N0–1M0) locally advanced laryngeal and laryngopharyngeal cancer. In the first phase of the treatment, all 24 patients included into the study, received preoperative RT with local hyperthermia. Preventive tracheostoma was not an obstacle for the treatment. Patients who achieved partial response or stable disease underwent surgery. In case of complete tumor regression (n=5), radiotherapy was continued up to the total dose of 66 Gy. Histological examination of surgical specimens revealed complete pathological response in all patients who received combined modality treatment. Regional metastases were revealed in 2 patients, and they subsequently underwent lymph node dissection. The overall 2-year survival rate was 100 % and 2-year metastasis-free survival was 91.7 %.
About the Authors
E. L. Choynzonov
Tomsk Cancer Research Institute;
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Choynzonov Evgeny Lhamatsirenovich, MD, DSc, Academician of RAS, Professor, Director of the Tomsk Cancer Research Institute.
E-mail: nii@oncology.tomsk.ru. SPIN-code: 2240-8730.
M. R. Mukhamedov
Tomsk Cancer Research Institute;
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Muhamedov Marat Rafkatovich, MD, DSc, Leading researcher, Department head and neck tumors.
E-mail: muhamedov@oncology.tomsk.ru. SPIN-code: 6780-1498.
Zh. A. Startseva
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Startseva Zhanna Alexandrovna, MD, DSc, Head, Radiology Department.
E-mail: zhanna.alex@ rambler.ru. SPIN-code: 8121-0310.
I. O. Spivakova
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Spivakova Irina Olegovna, Postgraduat Student, Department head and neck tumors.
E-mail: irensp2005@mail.ru. SPIN-code: 5877-5820.
O. V. Cheremisina
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Cheremisina Olga Vladimirovna, MD, DSc, Head of Endoscopy Department.
E-mail: СheremisinaOV@oncology.tomsk.ru. SPIN-code: 9579-2691.
N. V. Vasilyev
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Vasilyev Nikolai Voltovich, MD, PhD, Senior Researcher, Laboratory of Pathological Anatomy and Cytology.
E-mail: vasilievasn@yandex.ru. SPIN-code: 1627-5226.
O. V. Gribova
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Gribova Olga Vjacheslavovna, MD, PhD, Researcher, Radiology Department.
E-mail: gribova79@mail.ru. SPIN-code: 1405-1669.
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Review
For citations:
Choynzonov E.L., Mukhamedov M.R., Startseva Zh.A., Spivakova I.O., Cheremisina O.V., Vasilyev N.V., Gribova O.V. COMBINED MODALITY TREATMENT INCLUDING LOCAL HYPERTHERMIA IN PATIENTS WITH LOCALLY-ADVANCED LARYNGEAL AND LARYNGOPHARYNGEAL CANCER. Siberian journal of oncology. 2015;(6):13-18. (In Russ.)
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