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CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF BILATERAL BREAST CANCER

Abstract

Background. The paper has been devoted to the study of clinical and morphological features of bilateral breast cancer (BC). Despite the increased interest in the lateral BC, pathogenesis of this type of cancer have been little studied. Мaterials and methods. Clinical and morphological parameters were studied in 600 patients with unilateral and bilateral breast carcinoma. Results. Synchronous and metachronic bilateral breast cancer is characterized by more pronounced heterogeneity of the morphological structure with the frequent presence of discrete groups of tumor cells and ductal structures in the tumor node as compared to unilateral breast cancer. Synchronous bilateral breast cancer has a favorable clinical course and is mainly represented by the luminal A molecular genetic type. Metachronous bilateral breast cancer is often characterized as a triple negative and luminal B type with high proliferative activity and is associated with poor prognosis. There is a difference in prognostic parameters of lymphogenous and hematogenous metastasis between synchronous and metachronous breast cancer. For synchronous bilateral breast cancer, morphological parameters can serve as prognostic factors of hematogenous and lymphogenous metastasis. For metachronous breast cancer, prognosis of hematogenous metastasis is associated with severity of lymphogenous metastasis. Conclusion. The data obtained allow us to determine the typical clinical and morphological features of synchronous and metachronous bilateral breast cancers, as well as to identify additional prognostic parameters of tumor progression.

About the Authors

М. V. Zavyalova
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute; National Research Tomsk State University
Russian Federation

Zavyalova Marina Viktorovna, MD, Professor, Head of Pathological Anatomy Department, Siberian State Medical University (Tomsk).

E-mail: zavyalovamv@mail.ru. SPIN-code: 1229-0323 . 



N. V. Krakhmal
Siberian State Medical University, Tomsk
Russian Federation

Krakhmal Nadezhda Valerievna, MD, postgraduate, lecturer of the Department of Pathological Anatomy.

E-mail: krakhmal@mail.ru. SPIN-code: 1543-6546. 



Е. A. Fesik
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute
Russian Federation

Fesik Evgenia Anatolyevna, MD, PhD, pathologist, Department of Pathological Anatomy and Cytology, Tomsk Cancer Research
Institute.

E-mail: fesik-evgenija@rambler.ru. SPIN-code: 6622-7291.



L. N. Bondar
Tomsk Cancer Research Institute
Russian Federation

Bondar Lyudmila Nikolaevna, MD, pathologist, Department of Pathological Anatomy and Cytology.

E-mail: bondaroncology@mail.ru. SPIN-code: 



Е. М. Slonimskaya
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute
Russian Federation

Slonimskaya Elena Mikhailovna, MD, Professor, Head of General Oncology Department, Tomsk Cancer Research Institute.
E-mail: slonimskaya@rambler.ru. SPIN-code: 7763-6417



S. V. Vtorushin
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute
Russian Federation

Vtorushin Sergey Vladimirovich, MD, Professor, Pathological Anatomy Department,SiberianStateMedicalUniversity(Tomsk).

E-mail: wtorushin@rambler.ru. SPIN-code: 2442-4720. 



V. M. Perelmuter
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute
Russian Federation

Perelmuter Vladimir Mikhailovich, MD, Professor, Head of Department of Pathological Anatomy and Cytology, Tomsk Cancer Research Institute.

E-mail: pvm@ngs.ru. SPIN-code: 6252-5319. 



О. Е. Savelyeva
Siberian State Medical University, Tomsk; Tomsk Cancer Research Institute
Russian Federation

Savelyeva Olga Evgenievna, MD, DSc, Senior Researcher, Department of Pathological Anatomy and Cytology, Tomsk Cancer Research Institute.

E-mail: olga.sav.1980@gmail.com. SPIN-code: 9633-9449.



References

1. Ablitsova N.V., Ermakov A.V., Rasskazova E.A., Saribekian É.K., Tyshchenko E.V. Bilateral synchronous breast cancer: Long-term results of treatment // Onkologija. 2014. № 1. P. 14–18. [in Russian]

2. Zavyalova M.V., Shvedova M.V., Perelmuter V.М., Slonimskaya Е.М., Vtoryshin S.V., Telegina N.S., Savenkova О.V. Clinicalmorphological characteristics of bilateral invasive ductal breast cancer // Sibirskij onkologicheskij zhurnal. 2010. № 6. P. 17–21. [in Russian]

3. Imjanitov E.N. Hereditary breast cancer // Prakticheskaja onkologija. 2010. Vol. 11 (4). P. 258–265 [in Russian]

4. Baker B., Morcos B., Daoud F., Sughayer M., Shabani H., Salameh H., Almasri M. Histo-boilogical comparative analysis of bilateral breast cancer // Med. Oncol. 2013. Vol. 30 (4). P. 711–718. doi: 10.1007/s12032-013- 0711-8.

5. Beckmann K.R., Buckingham J., Craft P., Dahlstrom J.E., Zhang Y., Roder D., Stuart-Harris R. Clinical characteristics and outcomes of bilateral breast cancer in Australian cohort // Breast. 2011. Vol. 20 (2). P. 158–164. doi: 10.1016/j.breast.2010.10.004.

6. Chen S.F., Du C.W., Yang P., Zhang H.W., Kwan M., Zhang G.J. The molecular and clinicopathologic characteristics of bilateral breast cancer // Sci. Rep. 2013. Vol. 3. P. 2590. doi: 10.1038/srep02590.

7. Diaz R., Munarriz B., Santaballa A., Palomar L., Montalar J. Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience // Med. Oncol. 2012. Vol .29 (1). P. 16–24. doi: 10.1007/s12032-010-9785-8.

8. Huo D., Melkonian S., Rathouz P.J., Khramtsov A., Olopade O.I. Concordance in histological and biological parameters between first and second primary breast cancers // Cancer. 2011. Vol. 117 (5). Р. 907–915. doi: 10.1002/cncr.25587.

9. Kheirelseid E.A., Jumustafa H., Miller N., Curran C., Sweeney K., Malone C., McLaughlin R., Newell J., Kerin M.J. Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics // Breast Cancer Res. Treat. 2011. Vol. 126 (1). P. 131–140. doi: 10.1007/s10549-010-1057-y.

10. Londero A.P., Bernardi S., Bertozzi S., Angione V., Gentile G., Dri C., Minucci A., Caponnetto F., Petri R. Synchronous and metachronous breast malignancies: A cross-sectional ratrospective study and review of the literature // Biomed. Res. Int. 2014; 2014: 250727. doi: 10.1155/2014/250727.

11. Narod S.A. Bilateral breast cancer // Nat. Rev. Clin. Oncol. 2014. Vol. 11 (3). P. 157–166. doi: 10.1038/nrclinonc.2014.3.

12. Schmid S.M., Pfefferkorn C., Myrick M.E., Viehl C.T., Obermann E., Schötzau A., Güth U. Prognosis of early-stage synchronous bilateral invasive breast cancer // Eur. J. Surg. Oncol. 2011. Vol. 37 (7). P. 623–628. doi: 10.1016/j.ejso.2011.05.006.

13. Wang T., Liu H., Chen K.X., Xun P., Li H.X., Tang S.C. The risk factors and prognosis of bilateral primary breast cancer: a comparative study with unilateral breast cancer // Oncol. Res. 2011. Vol. 19 (3–4). P. 171–178.

14. Xing Y., Meng Q., Sun L., Chen X., Cai L. Survival analysis of patients with unilateral and bilateral primary breast cancer in Northeast China // Breast Cancer. 2015. Vol. 22 (5). P. 536–543. doi: 10.1007/ s12282-014-0517-3.

15. Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Denisov E.V., Litvyakov N.V., Slonimskaya E.M., Cherdyntseva N.V. The presence of alveolar structures in invasive ductal NOS breast carcinoma is associated with lymph node metastasis // Diagn. Cytopathol. 2013. Vol. 41 (3). P. 279–282. doi: 10.1002/dc.21852.


Review

For citations:


Zavyalova М.V., Krakhmal N.V., Fesik Е.A., Bondar L.N., Slonimskaya Е.М., Vtorushin S.V., Perelmuter V.M., Savelyeva О.Е. CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF BILATERAL BREAST CANCER. Siberian journal of oncology. 2015;(6):26-32. (In Russ.)

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)