On the role of autophagy in the progression of differentiated thyroid cancer (literature review)
https://doi.org/10.21294/1814-4861-2021-20-6-134-140
Abstract
The aim of the study was to analyze and summarize available literature data on the role of autophagy in thyroid cancer. Material and methods. We analyzed 34 publications available from pubmed and elibrary. Ru databases concerning thyroid cancer and autophagy. Results. The review discussed the role of autophagy in the progression of thyroid cancer. The development of autophagy-targeted therapy was shown can improve treatment for thyroid cancer. Differentiated thyroid cancer (dtc) is the most common endocrine malignancy. Treatment of dtc patients who are resistant to radioactive iodine therapy is a major challenge. Molecular targeted therapy using tyrosine kinase inhibitors significantly improves treatment outcomes. Conclusion. To enhance the therapeutic effect of treatment with multi-target tyrosine kinase inhibitors, as well as to overcome drug resistance, it is necessary to study the role of autophagy in the development and progression of thyroid cancer.
About the Authors
K. A. Garipov
Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education;
Republican Clinical Cancer Center of Ministry of Health of the Republic of Tatarstan
Russian Federation
Russian Federation
MD, Postgraduate, Department of Oncology, Radiology and Palliative Medicine; Oncologist, Department No. 4
SPIN-код: 9013-7722
36, Butlerova st., 420012, Kazan, Russia
29, Sibirsky trakt, 420029, Kazan, Russia
Z. A. Afanaseva
Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education;
Republican Clinical Cancer Center of Ministry of Health of the Republic of Tatarstan
Russian Federation
Russian Federation
MD, DSc, Professor, Department of Oncology, Radiology and Palliative Medicine; Head of the Center for Diagnosis and Treatment of Patients with Thyroid Cancer and Other Endocrine Organs
SPIN-код: 9921-0860. Researcher ID (WOS): AAE-2027-2020. Author ID (Scopus): 57196436798
36, Butlerova st., 420012, Kazan, Russia
29, Sibirsky trakt, 420029, Kazan, Russia
Z. I. Abramova
Federal University Kazan (Volga Region) Federal University, Institute of Fundamental Medicine and Biology
Russian Federation
Russian Federation
DSc, Professor, Department of Biochemistry, Biotechnology and Pharmacology, Institute of Fundamental Medicine and Biology; Chief Researcher, Laboratory of Molecular Foundations of Pathogenesis and Therapy of Tumor Diseases, Institute of Physics and Mathematics and Biology, Kazan Federal University
SPIN-код: 5293-9741. Researcher ID: N-6976-2013. Author ID (Scopus): 24833015100
18, Kremlin st., 420008, Kazan, Russia
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Review
For citations:
Garipov K.A., Afanaseva Z.A., Abramova Z.I. On the role of autophagy in the progression of differentiated thyroid cancer (literature review). Siberian journal of oncology. 2021;20(6):134-140. (In Russ.) https://doi.org/10.21294/1814-4861-2021-20-6-134-140
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