THE FIRST EXPERIENCE OF USING LOCAL HYPERTHERMIA IN COMBINED MODALITY TREATMENT OF OPERABLE NON-SMALL CELL LUNG CANCER
Abstract
The paper presents the first experience in treating 5 patients with stage II–III non-small cell lung cancer using combined modality treatment including 40 Gy preoperative hyperfractionated radiotherapy with concurrent 2 cycles of paclitaxel/carboplatin chemotherapy and local hyperthermia (10 sessions) followed by radical surgery. The overal response rate to preoperative treatment was 80 %. Chemotherapy was well tolerated and hyperthermia resulted no in adverse effects. All patients underwent surgery (4 lobectomies and 1 pneumonectomy). No complications were observed in the postoperative period. The follow-up period ranged from 6 to 20 months. No evidence of disease progression and radiation-induced damages were observed.
About the Authors
A. Yu. Dobrodeev
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Dobrodeev Alexei Yuryevich, MD, DSc, Senior Researcher, Thoracic and Abdominal Department.
E-mail: dobrodeev@oncology.tomsk.ru. SPIN-code: 5510-4043.
A. A. Zavyalov
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Zavyalov Aleksandr Aleksandrovich, MD, DSc, Senior Researcher, Thoracic and Abdominal Department.
E-mail: ZavyalovAA@oncology.tomsk.ru. SPIN-code: 5087-2394.S. А. Tuzikov
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Tuzikov Sergey Aleksandrovich, MD, DSc., Professor, Head of The Thoracal and Abdominal Department.
E-mail: TuzikovSA@oncology. SPIN-code: 5662-6431.
Zh. A. Startseva
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Startseva Zhanna Alexandrovna, MD, DSc, Head, Radiology Department.
E-mail: zhanna.alex@ rambler.ru. SPIN-code: 8121-0310.
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Review
For citations:
Dobrodeev A.Yu., Zavyalov A.A., Tuzikov S.А., Startseva Zh.A. THE FIRST EXPERIENCE OF USING LOCAL HYPERTHERMIA IN COMBINED MODALITY TREATMENT OF OPERABLE NON-SMALL CELL LUNG CANCER. Siberian journal of oncology. 2015;(6):52-56. (In Russ.)
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