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THE INTRACELLULAR AND CIRCULATING POOLS OF PROTEASOMES: THE VALUE AT CANCER IN DIFFERENT LOCATIONS

Abstract

This review presents the structure of the proteasome system, discusses its involvement in the pathogenesis of many cancers, including the process of metastasis. It describes the distinctive structural characteristics of intra- and extracellular pools of proteasomes, possible ways of their exit into the extracellular space and their forms of existence outside the cell. Also in the present review discusses the importance of circulating proteasomes for prognosis course of the cancer.

About the Authors

E. E. Shashova
Tomsk Cancer Research Institute
Russian Federation

Shashova Elena Evgenievna, MD, PhD, Senior Researcher, Tumor Biochemistry Laboratory.

E-mail: SchaschovaEE@oncology.tomsk.ru. SPIN-code: 5079-8784.


E. S. Kolegova
Tomsk Cancer Research Institute; Siberian State Medical University, Tomsk
Russian Federation

Kolegova Elena Sergeevna, assistant researcher, Tumor Biochemistry Laboratory.

E-mail: elenakolegova@oncology.tomsk.ru. SPIN-code: 5865-1264.



I. V. Kondakova
Tomsk Cancer Research Institute
Russian Federation

Kondakova Irina Viktorovna, MD, Professor, Tumor Biochemistry Laboratory.

Phone: +7 3822 51-25-29. E-mail: kondakova@oncology.tomsk.ru. SPIN-code: 9338-4149



A. A. Zavyalov
Tomsk Cancer Research Institute; Siberian State Medical University, Tomsk
Russian Federation

Zavyalov Alexandr Alexandrovich, MD, DSc, Principal Researcher, Thoracic and Abdominal Department.

E-mail: ZavyalovAA@oncology.tomsk.ru. SPIN-code: 5087-2394.



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Review

For citations:


Shashova E.E., Kolegova E.S., Kondakova I.V., Zavyalov A.A. THE INTRACELLULAR AND CIRCULATING POOLS OF PROTEASOMES: THE VALUE AT CANCER IN DIFFERENT LOCATIONS. Siberian journal of oncology. 2015;(6):76-82. (In Russ.)

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)