MOLECULAR MECHANISMS THAT LEAD TO CHOLANGIOCARCINOMA, DURING CHRONIC INFECTION OF LIVER FLUKES
Abstract
Cholangiocarcinoma is a malignant tumor, characterized by poor prognosis and a low five-year survival rate. There is a clear correlation between the incidence of opisthorchiasis and high incidence of cholangiocarcinoma in South-East Asia. Liver flukes Clonorchis sinensis and Opisthorchis viverrini are I class carcinogens. There are some endemic regions of opisthorchiasis In the Russian Federation. The most important factor that leads to carcinogenesis during liver fluke infection is chronic inflammation. This review article focuses on the communication of chronic inflammation caused by invasion of liver flukes and cholangiocarcinoma. This paper summarizes the current knowledge about the risk factors for cholangiocarcinoma, as well as knowledge about the molecular aspects of the induction of carcinogenesis by liver flukes.
About the Authors
A. O. Bogdanov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Bogdanov Alexandr Olegovich, student, Medical-Biological Faculty.
E-mail: AxeBogdanov@gmail.com. SPIN-code: 7566-5860.
D. V. Prokudina
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Prokudina Daria Vladimirovna, student, Medical-Biological Faculty.
E-mail: dariya1992@mail.ru. SPIN-code: 7768-5902.
A. N. Baykov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Baikov Alexandr Nikolaevich, MD, DSc, Head of Central Research Laboratory.
SPIN-code: 3510-4400.
I. V. Saltykova
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Saltykova Irina Vladimirovna, MD, PhD, Researcher, Central Research Laboratory.
E-mail: ira.saltikova@mail.ru. SPIN-code: 9432-3873.
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Review
For citations:
Bogdanov A.O., Prokudina D.V., Baykov A.N., Saltykova I.V. MOLECULAR MECHANISMS THAT LEAD TO CHOLANGIOCARCINOMA, DURING CHRONIC INFECTION OF LIVER FLUKES. Siberian journal of oncology. 2015;(6):83-90. (In Russ.)
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