ROLE OF LOCAL HYPERTHERMIA IN COMBINED MODALITY TREATMENT OF SOFT TISSUE SARCOMAS
Abstract
The review aimed to assess the role of local hyperthermia in combined modality treatment of soft tissue sarcoma. The recent randomized trials have shown significant benefits from local hyperthermia in patients with soft tissue sarcoma. When combined with radiotherapy, hyperthermia has a complementary and additive effect. Extensive researches have also shown that hyperthermia improves the efficacy of many chemotherapeutic agents. Besides the increased effectiveness of radiotherapy and chemotherapy, hyperthermia has many anti-cancer effects and improves treatment results in patients with soft tissue sarcomas.
About the Authors
Zh. A. Startseva
Tomsk Cancer Research Institute; National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Startseva Zhanna Alexandrovna -MD, DSc, Head, Radiology Department.
Phone: +7 3822 418065. E-mail: clinica@oncology.tomsk.ru. SPIN-code: 8121-0310
Е. М. Slonimskaya
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Slonimskaya Elena Mikhailovna - Slonimskaya Elena Mikhailovna, MD, DSC, Professor, Head, General Oncology Department.
Phone: +7 3822 418092. E-mail: slonimskaya@rambler.ru. SPIN-code: 7763-6417
Yu. I. Tyukalov
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Tyukalov Yury Ivanovich - MD, PhD, Head Physician.
Phone: +7 3822 418080. E-mail: clinica@oncology.tomsk.ru. SPIN-code: 4237-0505
I. G. Frolova
Tomsk Cancer Research Institute; National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Frolova Irina Georgievna - MD, DSc., Professor, Head of the Diagnostic Imaging Department.
Phone: +73822 420057. E-mail: FrolovaIG@oncology.tomsk.ru
A. A. Zheravin
Tomsk Cancer Research Institute; National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Zheravin Alexandr Alexandrovich - MD, PhD, Senior Researcher, General Oncology Department.
Phone: +7 3822 418093. E-mail: zheravin2010@yandex.ru. SPIN-code: 2858-7175
A. I. Konovalov
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Konovalov Artyem Igorevich - junior researcher, Radiology Department.
Phone: +79234090300. E-mail: Armany-2008@yandex.ru
К. A. Simonov
Tomsk Cancer Research Institute; National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Simonov Kirill Alexandrovich - MD, PhD, oncologist, Radiology Department.
Phone: +7 3822420062. SPIN-code: 4267-9490
А. V. Bogoutdinova
Tomsk Cancer Research Institute; National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Bogoutdinova Anna Vladimirovna - MD, PhD, General Oncology Department.
Phone: +7 3822 418093, e-mail: clinica@oncology.tomsk.ru, SPIN-code 6120-7933
О. V. Kotova
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Kotova Olga Viktorovna - Postgraduat Student, Diagnostic Imaging Department.
Phone: +7 3822418090. E-mail: clinica@oncology.tomsk.ru. SPIN-code: 9058-9343
References
1. Aliev M.D. Современные подходы к лечению сарком мягких тканей // Prakticheskaja onkologija. 2004. № 20. P. 250–255. [in Russian]
2. Andronova N.V., Bokhyan B.Yu., Nikolaev A.L., Treshalina E.M., Aliev M.D., Filonenko D.V., Gopin A.V., Bozhevolnov V.E., Kogan B.Ya., Vorozhtcov G.N. Rationale for clinical study of preoperative treatment of soft tissue sarcomas with local ultrasound hyperthermia and chemotherapy with cisplatin and/ or doxorubicin // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2011. № 1. P. 28–33. [in Russian]
3. Burov D.A., Bokhyan B.U., Huseinov Z.H., Fedenko A.A., Martynkov D.V., Khaylenko V.A. Mistakes and complications in the treatment of soft tissue sarcomas // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2011. № 3. P. 29–36. [in Russian]
4. Davydov M.I., Aksel’ E.M. Статистика злокаче ственных новообразований в России и странах СНГ в 2010 г. // Vestnik RONC im. N.N. Blohina. 2012. № 10. P. 155–158. [in Russian]
5. Dobrodeev A.Yu., Zavyalov A.A., Tuzikov S.A., Startseva Zh.A., Kostromitsky D.N. Hyperthermia in treatment of non-small cell lung cancer // Sibirskij onkologicheskij zhurnal. 2014. № 4. P. 60–65. [in Russian]
6. Zhamgarjan G.S., Tjukalov Ju.I., Starceva Zh.A., Kotova O.V, Konovalov A.I, Zheravin A.A. Предоперационная гамма-терапия с локальной гипертермией у больных с рецидивами сарком мягких тканей // Evrazijskij onkologicheskij zhurnal 2014. № 3. P. 643. [in Russian]
7. Zubarev A.L., Kurilchik A.A., Kudryavtseva G.T., Kurpeshev O.K., Starodubtsev A.L., Ivanov V.E. Thermo-chemo-radio-therapy in the combined treatment of locally advanced soft tissue sarcomas (STS) // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2011. № 1. P. 34–38. [in Russian]
8. Kaprin A.D., Starinskij V.V., Petrova G.V. Состояние онкологической помощи населению России в 2012 году. M., 2013. P. 28. [in Russian]
9. Kuleshova D.V., Loshhenov V.B., Shevchik S.A., Barun V.V. Эксперимент ально е и теоретиче ско е исследование лазерной гипертермии биологической ткани // Al’manah klinicheskoj mediciny. 2006. № 12. P. 25. [in Russian]
10. Kurpeshev O.K., Zubarev A.L. Результаты химиои термолучевой терапии больных с саркомой мягких тканей, подвергшихся и не подвергшихся оперативному вмешательству // Onkologija. 2006. Vol. 8 (3). P. 255–259. [in Russian]
11. Kurpeshev O.K., Mardynskij Ju.S., Berdov B.A. Локальная электромагнитная гипертермия в лечении злокачественных опухолей: Методическое пособие для врачей. Obninsk, 2001. [in Russian]
12. Musabaeva L.I., Startseva Zh.A. Intraoperative electon radiation therapy and external beam radiation therapy for stage I-II breast cancer (literature review) // Sibirskij onkologicheskij zhurnal. 2011. № 2. P. 79–85. [in Russian]
13. Pisareva L.F., Chojnzonov E.L., Tahauov R.M. Рак гортани на территории Сибири и Дальнего Востока (основные статистические показатели) // Sibirskij onkologicheskij zhurnal. 2003. № 2. P. 44–46. [in Russian]
14. Tamrazov R.I., Barsukov Y.A., Tkachev S.I., Nikolayev A.V., Gordeyev S.S. Local hyperthermia in rectal cancer treatment: a view on the future from the past // Onkologicheskaja koloproktologija. 2011. № 3. P. 12–21. [in Russian]
15. Teplyakov V.V., Bukharov F.D., Urlova A.N., Karpenko V.U., Derzhavin V.A., Mislevtsev I.V., Yakovleva E.C. Diagnostic and treatment mistakes in managing of soft tissue sarcomas // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2012. № 1. P. 29–35. [in Russian]
16. Tkachev S.I., Aliev M.D., Glebovskaya V.V., Yarmonenko S.P., Wainson A.A., Ivanov S.M., Trofimova O.P., Karapetyan R.M., Bokhyan B.Yu., Yaghunovich I.P. Thermoradiotherapy as a component of desmoid tumor management // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2009. № 1. P. 34–37. [in Russian]
17. Fedenko A.A., Gorbunova V.A., Bokhyan B.Yu., Aliev M.D., Istomin I.A. Trabectedin in the treatment of soft tissue sarcomas. First russian experience // Sarkomy kostej, mjagkih tkanej i opuholi kozhi. 2011. № 2. P. 47–54. [in Russian]
18. Choynzonov E.L., Startseva Zh.A., Mukhamedov M.R., Spivakova I.O., Cheremisina O.V., Gribova O.V., Kulbakin D.E., Surkova P.V. Local hyperthermia in combined modality treatment of laryngeal and laryngopharyngeal cancer // Sibirskij onkologicheskij zhurnal. 2014. № 5. P. 5–9. [in Russian]
19. Shevchenko L.N. Radiation therapy for the locally advanced cervical carcinoma in the condition of the local laser-induced hyperthermia // Vestnik Rossijskogo nauchnogo centra rentgenologii Minzdrava Rossii. 2010. Vol. 1 (10). P. 14. [in Russian]
20. Belal A., Kandil A., Allam A., Khafaga Y., El-Husseiny G., El-Enbaby A., Memon M., Younge D., Moreau P., Gray A., Schultz H. Malignant fibrous histiocytoma: a retrospective study of 109 cases // Am. J. Clin. Oncol. 2006. Vol. 25 (1). С. 16–22.
21. De la Mata M.D., Gomez-Espi M., Loano M.A. et al. Preoperative chemoradiation +/− IORT in esophageal cancer // Proc. of the Intern. Soc. Intraoperative Radiation Therapy. 2005. P. 247–278.
22. Demetri G.D., Chawla S.P., von Mehren M., Ritch P., Baker L.H., Blay J.Y., Hande K.R., Keohan M.L., Samuels B.L., Schuetze S., Lebedinsky C., Elsayed Y.A., Izquierdo M.A., Gómez J., Park Y.C., Le Cesne A. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules // J. Clin. Oncol. 2009. Vol. 27 (25). P. 4188–4196. doi: 10.1200/JCO.2008.21.0088.
23. Gatta G., Ciccolallo L., Kunkler I., Capocaccia R., Berrino F., Coleman M.P., De Angelis R., Faivre J., Lutz J.M., Martinez C., Möller T., Sankila R. Survival from rare cancer in adults: a population-based study // Lancet Oncol. 2006. Vol. 7 (2). Р. 132–140.
24. Gronchi A., Lo Vullo S., Fiore M., Mussi C., Stacchiotti S., Collini P., Lozza L., Pennacchioli E., Mariani L., Casali P.G. Aggressive surgical policies in a retrospectively reviewed singleinstitution case series of retroperitoneal soft tissue sarcoma patients // J. Clin. Oncol. 2009. Vol. 27 (1). P. 24–30. doi: 10.1200/JCO.2008.17.8871.
25. Issels R.D., Lindner L.H., Verweij J., Wust P., Reichardt P., Schem B.C., Abdel-Rahman S., Daugaard S., Salat C., Wendtner C.M., Vujaskovic Z., Wessalowski R., Jauch K.W., Dürr H.R., Ploner F., Baur-Melnyk A., Mansmann U., Hiddemann W., Blay J.Y., Hohenberger P. Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised highrisk soft-tissue sarcoma: a randomised phase 3 multicentre study. For the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG), the European Society for Hyperthermic Oncology (ESHO). 2010.
26. Jemal A. World Cancer Statistics, 2006. CA Cancer // J. Clin. 2006. Vol. 56. P. 106.
27. Kaur P., Hurwitz M.D., Krishnan S., Asea A. Combined Hyperthermia and Radiotherapy for the Treatment of Cancer // Cancers (Basel). 2011. Vol. 3 (4). P. 3799–3823. doi: 10.3390/cancers3043799.
28. O′Sullivan B., Davis A.M. A randomized phase III phase trial of preoperative compared to postoperative radiotherapy in extremity soft tissue sarcoma // Proc. ASTRO. 2001. Vol. 51. P. 151.
29. Shibata S.I., Pezner R., Chu D., Doroshow J.H., Chow W.A., Leong L.A., Margolin K.A., McNamara M.V., Morgan R.J. Jr., Raschko J.W., Somlo G., Tetef M.L., Yen Y., Synold T.W., Wagman L., Vora N., Carroll M., Lin S., Longmate J. A study of radiotherapy modalities combined wish continuous 5-FU infusion for locally advanced gastrointestinal malignancies // Eur. J. Sur. Oncol. 2004. Vol. 30 (6). P. 650–657.
30. Stoeckle E., Coindre J.M., Kind M., Kantor G., Bui B.N. Evaluating surgery quality in soft tissue sarcoma // Recent Results Cancer Res. 2009. Vol. 179. P. 229–242.
31. van der Zee J. Heating the patient: a promising approach? // Ann. Oncol. 2002. Vol. 13 (8). P. 1173–1184.
32. van der Zee J., Vujaskovic Z., Kondo M., Sugahara T. The Kadota Fund International Forum 2004-Clinical group consensus // Int. J. Hyperthermia. 2008. Vol. 24 (2). P. 111–122. doi: 10.1080/02656730801895058.
33. Wendtner C.M., Abdel-Rahman S., Krych M., Baumert J., Lindner L.H., Baur A., Hiddemann W., Issels R.D. Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas // J. Clin. Oncol. 2002. Vol. 20 (14). P. 3156–3164.
Review
For citations:
Startseva Zh.A., Slonimskaya Е.М., Tyukalov Yu.I., Frolova I.G., Zheravin A.A., Konovalov A.I., Simonov К.A., Bogoutdinova А.V., Kotova О.V. ROLE OF LOCAL HYPERTHERMIA IN COMBINED MODALITY TREATMENT OF SOFT TISSUE SARCOMAS. Siberian journal of oncology. 2015;1(3):76-81. (In Russ.)
Views:
789
Email this article 
