THE USE OF INNOVATIVE DOMESTIC CONTRAST AGENT GADOLINIUM-BASED FOR MR-CANCER DIAGNOSIS IN EXPERIMENT
Abstract
The present study of the functional suitability and specific activity of the contrast agent gadolinium-based for magnetic resonance imaging demonstrated that the investigated contrast agent intensively accumulates in organs and anatomical structures of the experimental animals. In the model of tumor lesions in animals, study have shown that investigational contrast agent accumulates in the tumor tissue and retained there in for a long enough time.
About the Authors
V. I. Chernov
Tomsk Саnсеr Rеsеаrсh Institute;
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
A. A. Titskaya
Tomsk Саnсеr Rеsеаrсh Institute;
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
I. G. Sinilkin
Tomsk Саnсеr Rеsеаrсh Institute;
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Sinilkin Ivan Gennadyevich, MD, PhD, Senior Researcher, Nuclear Medicine Department,TomskCancer Research. Institute.
Phone: +7 (3822) 42-00-59. E-mail: sinilkinig@oncology.tomsk.ru. SPIN-code: 7254-3474
R. V. Zelchan
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
Zelchan Roman Vladimirovich, MD, PhD, radiologist, Nuclear Medicine Department, Tomsk Cancer Research Institute, Nuclear Medicine Department.
Phone: +7 (3822) 42-00-59. E-mail: r.zelchan@ yandex.ru. SPIN-code: 2255-5282
E. G. Grigoryev
Tomsk Саnсеr Rеsеаrсh Institute
Russian Federation
Russian Federation
Grigoriev Evgeny Gennadievich, MD, PhD, Senior Researcher, Diagnostic Imaging Department.
Phone: +7 (3822) 41-80-90. E-mail: adresprostoy@gmail.com. SPIN-code: 2079-2370
I. G. Frolova
Tomsk Саnсеr Rеsеаrсh Institute
Russian Federation
Russian Federation
Frolova Irina Georgievna, MD, DSc, Professor, Head of the Diagnostic Imaging Department.
Phone: +7 (3822) 42-00-57. E-mail: FrolovaIG@oncology.tomsk.ru. SPIN-code: 9800-9777
I. F. Nam
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
NamIrina Felixovna, PhD, Assistant Professor of Industrial and Medical Electronics.
Phone: +7 (3822) 48-85-00. E-mail: iphn@mail.ru
References
1. Brasch R.C., Weinmann H.-J., Wesbey G.E. Contrast-Enhanced NMR Imaging: Animal Studies Using Gadolinium-DTPA complex // AJR. 1984. Vol. 142 (3). P. 625–630.
2. Carr D.H., Brown J., Bydder G.M., Weinmann H.J., Speck U., Thomas D.J., Young I.R. Intravenous chelated gadolinium as a contrast agent in NMR imaging of cerebral tumours // Lancet. 1984. Vol. 1 (8375). P. 484–486.
3. Laniado M, Weinmann HJ, Schörner W, Felix R, Speck U. First use of GdDTPA/dimeglumine in man // Physiol. Chem. Phys. Med. NMR. 1984. Vol. 16 (2). Р.157–165.
4. Weinmann H.J., Brasch R.C., Press W.R., Wesbey G.E. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent // AJR. 1984. Vol. 142 (3). P. 619–624.
5. Weinmann H.J., Ebert W., Misselwitz B., Schmitt-Willich H. Tissuespecific MR contrast agents // Eur. J. Radiol. 2003. Vol. 46 (1). P. 33–44.
6. Weinmann HJ, Laniado M, Mützel W. Pharmacokinetics of Gd- DTPA/dimeglumine after intravenous injection into healthy volunteers // Physiol. Chem. Phys. Med. NMR. 1984. Vol. 16 (2). P. 167–172.
Review
For citations:
Chernov V.I., Titskaya A.A., Sinilkin I.G., Zelchan R.V., Grigoryev E.G., Frolova I.G., Nam I.F. THE USE OF INNOVATIVE DOMESTIC CONTRAST AGENT GADOLINIUM-BASED FOR MR-CANCER DIAGNOSIS IN EXPERIMENT. Siberian journal of oncology. 2015;1(4):45-50. (In Russ.)
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