Preview

Siberian journal of oncology

Advanced search

FEATURES PATHOMORPHOLOGICAL MANIFESTATIONS OF DYSPLASTIC CHANGES OF VARIOUS DEGREES IN THE CERVIX IN WOMEN OF DIFFERENT AGE GROUPS

Abstract

Morphological and morphometric study of biopsy showed that in the 2 age groups of subjects: 1 – 65 women of reproductive age to 35 years old, 2 – 57 women postreproductive age, over 49 years. Patients of the 1-st group were more frequent CIN2 and CIN3. It is revealed that the patients of this group in the stratified squamous epithelium of the cervix are more active processes of proliferation, expressed as a thickening layer of stratified squamous epithelium on the whole, the thickening of the basal layer, more common acanthosis, in comparison with changes of stratified squamous epithelium in women of older age. It is established that the symptoms of viral lesions of the stratified squamous epithelium (koilocytes), often encountered in young women. Assessment of the manifestations of the reaction of local immunity in the stroma of the cervix showed that more severe inflammatory reaction was marked in young patients with CIN3 as the most active perifocal inflammatory process.

About the Authors

M. S. Seliakova
Novosibirsk State Medical University
Russian Federation

Selyakova Maria Sergeevna, Postgraduate of the Department of Pathological Anatomy.

Phone: 8 (953) 762-66-86. E-mail: mari.selyakova@mail.ru



T. A. Ageeva
Novosibirsk State Medical University
Russian Federation

Ageeva Tatyana Avgustovna, DSc, Professor of the Department of Pathological Anatomy.

Phone: 8 (903) 937-50-51. E-mail: ageta@mail.ru 



References

1. Babaeva A.G. Regeneration: facts and prospects. M., 2009. 336 p. [in Russian]

2. Diseases of cervix, vagina and vulva (the Wedge lectures) / Ed. V.N. Prilepskaya. M., 2000. 432 p. [in Russian]

3. Korolenkova L.I. Associated with infection of the human papilloma virus markers for the occurrence and progression of cervical intraepithelial neoplasms: from research to clinical practice // Tumors of the female reproductive system. 2010. № 4. P. 64–70. [in Russian]

4. Krasnopol’skiy V.I., Zarochentseva N.V., Belaya Yu.M., Shipulina O.Yu., Mikheeva I.V., Serova O.F., Mel’nik T.N. Human papillomavirus infection rates among female adolescents in the Moscow Region // The Russian Bulletin of the obstetrician-gynecologist. 2010. № 5. P. 46–49. [in Russian]

5. Minkina G.N., Manukhin I.B., Frank G.A. The cervical precancer. M., 2001. 112 p. [in Russian]

6. Tumors of the cervix (the manual for doctors) / Ed. Yu.Yu. Andreeva, G.A. Frank. M., 2012. P. 8–19. [in Russian]

7. Postmortem diagnosis of human tumors / Ed. N.A. Kraevskiy, A.V. Smol’yannikov, D.S. Sarkisov. M., 1993. Vol. 2. P. 222–235. [in Russian]

8. Middleton K., Peh W., Southern S., Griffin H., Sotlar K., Nakahara T., El-Sherif A., Morris L., Seth R., Hibma M., Jenkins D., Lambert P., Coleman N., Doorbar J. Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers // J. Virol. 2003. Vol. 77 (19). P. 10186–10201.

9. Munoz N., Bosch F.X., de Sanjose S., Herrero R., Castellsague X., Shah K.V., Snijders P.J., Meijer C.J. Epidemiologic classification of human papillomavirus types associated with cervical cancer // N. Engl. J. Med. 2003. Vol. 348 (6). P. 518–527.

10. Pathology and Genetics of Tumours of the Breast and Female Genital Organs (WHO Classification of Tumours) / Ed. Fattaneh A. Tavassoli, Peter Devilee. Lyon.: IARCPress. 2003. P. 266–268.

11. Smith J.S., Munoz N., Herrero R., Eluf-Neto J., Ngelangel C., Franceschi S., Bosch F.X., Walboomers J.M., Peeling R.W. Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines // J. Infect. Dis. 2002. Vol. 185 (3). P. 324–331.

12. WHO Classification of Tumours of Female Reproductiw the Organs / Ed. Robert J. Kurman, Maria Luisa Carcangiu, C. Simon Herrington, Robert H. Young. International Agency for Research on Cancer. Lyon, 2014. P. 172–176.


Review

For citations:


Seliakova M.S., Ageeva T.A. FEATURES PATHOMORPHOLOGICAL MANIFESTATIONS OF DYSPLASTIC CHANGES OF VARIOUS DEGREES IN THE CERVIX IN WOMEN OF DIFFERENT AGE GROUPS. Siberian journal of oncology. 2015;1(4):58-62. (In Russ.)

Views: 644


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)