Polarization of macrophages: mechanisms, markers and factors of induction
A. A. Fedorov,
N. A. Ermak,
T. S. Gerashchenko,
E. B. Topolnitskii,
N. A. Shefer,
E. O. Rodionov,
M. N. Stakheyeva https://doi.org/10.21294/1814-4861-2022-21-4-124-136
Abstract
Macrophages are key components of the innate immune system. The variability of the macrophage’s participation in tumor progression, determined by their functional polarization, opens up a wide prospect for modulating their functional profile, primarily in the direction of increasing antitumor activity. The purpose of the study was to provide up-to-date data on the process of macrophage polarization, mechanisms of its regulation, polarization markers and induction factors. Material and methods. A search was made for available literature sources published in Web of Science, Scopus and other databases. more than 160 sources devoted to the study of the process of macrophage polarization were found, of which 121 were included in this review. Results. This review presents data on the molecular mechanisms and gene signatures associated with M1 and M2 polarization of macrophages. We displayed information on metabolic, phenotypic characteristics and cytokine profile of M1- and M2-macrophages, as well as highlighted data on polarization factors and targets of their action. Conclusion. The information presented in the review can serve as an information base for the development of experimental and clinical approaches for editing the functional profile of macrophages in order to control their involvement in various pathological processes.
Supporting agencies: The study was funded by RFBR, project number 20-315-90055.
About the Authors
A. A. Fedorov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Anton A. Fedorov - Postgraduate, Laboratory of Molecular Oncology and Immunology, Junior Researcher of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
5, Kooperativny St., 634050, Tomsk.
Researcher ID (WOS): AAG-8911-2020. Author ID (Scopus): 57211136209.
N. A. Ermak
Siberian State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Nikita A. Ermak - 6th year student, Siberian State Medical University of the Ministry of Health of Russia.
2, Moskovsky trakt, Tomsk, 634050.
T. S. Gerashchenko
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Tatiana S. Gerashchenko - PhD, Researcher of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
5, Kooperativny St., 634050, Tomsk.
Researcher ID (WOS): A-7011-2014. Author ID (Scopus): 55948412900.
E. B. Topolnitskii
Siberian State Medical University of the Ministry of Health of Russia; Tomsk Regional Clinical Hospital
Russian Federation
Russian Federation
Evgenii B. Topolnitskii - MD, Professor of the Department of Surgery with a Course of Mobilization Training and Disaster Medicine, Siberian State Medical University of the Ministry of Health of Russia; Head of the Department Thoracic Surgery, Tomsk Regional Clinical Hospital.
2, Moskovsky trakt, Tomsk, 634050; 96, Ivana Chernykh St., 634063, Tomsk.
Researcher ID (WOS): T-5818-2018. Author ID (Scopus): 35197267200.
N. A. Shefer
Tomsk Regional Oncology Center
Russian Federation
Russian Federation
Nikolay A. Shefer - MD, PhD, Oncologist of the Surgery Department, Tomsk Regional Oncology Center.
115, Lenina Ave., 634009, Tomsk.
Author ID (Scopus): 57211683932.
E. O. Rodionov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Evgenii O. Rodionov - MD, PhD, Senior Researcher of the Thoracic Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Assistant of the Department of Oncology, Siberian State Medical University of the Ministry of Health of Russia.
5, Kooperativny St., 634050, Tomsk; 2, Moskovsky trakt, Tomsk, 634050.
Researcher ID (WOS): B-7280-2017. Author ID (Scopus): 57189622130.
M. N. Stakheyeva
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Marina N. Stakheyeva - MD, DSc, Leading Researcher of the Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
5, Kooperativny St., 634050, Tomsk.
Researcher ID (WOS): C-6184-2012. Author ID (Scopus): 6505941716.
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Fedorov A.A., Ermak N.A., Gerashchenko T.S., Topolnitskii E.B., Shefer N.A., Rodionov E.O., Stakheyeva M.N. Polarization of macrophages: mechanisms, markers and factors of induction. Siberian journal of oncology. 2022;21(4):124-136. (In Russ.) https://doi.org/10.21294/1814-4861-2022-21-4-124-136
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