Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients
Abstract
BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularly

About the Authors
A. A. KashintsevRussian Federation
G. A. Yanus
Russian Federation
N. Yu. Kokhanenko
Russian Federation
V. M. Moiseenko
Russian Federation
M. D. Hanevich
Russian Federation
L. D. Roman
Russian Federation
A. G. Ievleva
Russian Federation
A. P. Sokolenko
Russian Federation
E. N. Suspitsin
Russian Federation
A. I. Budovskiy
Russian Federation
A. V. Togo
Russian Federation
N. M. Volkov
Russian Federation
R. V. Fadeev
Russian Federation
M. S. Dinikin
Russian Federation
A. K. Ivanova
Russian Federation
K. G. Shostko
Russian Federation
E. N. Imyanitov
Russian Federation
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Review
For citations:
Kashintsev A.A., Yanus G.A., Kokhanenko N.Yu., Moiseenko V.M., Hanevich M.D., Roman L.D., Ievleva A.G., Sokolenko A.P., Suspitsin E.N., Budovskiy A.I., Togo A.V., Volkov N.M., Fadeev R.V., Dinikin M.S., Ivanova A.K., Shostko K.G., Imyanitov E.N. Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients. Siberian journal of oncology. 2013;(5):39-44. (In Russ.)