CHEMOTHERAPY IN COMBINED MODALITY TREATMENT FOR LOCALLY ADVAMCED NON-SMALL CELL LUNG CANCER
Abstract
The comparative analysis of immediate and long-term clinical outcomes in 68 patients with stage III non-small cell lung cancer was carried out. The study group comprised 36 patients who received 2 cycles of neoadjuvant vinorelbin/carboplatin-containing chemotherapy with subsequent assessment of objective response. If complete and partial responses were achieved and in cases with stable disease, patients underwent radical surgery followed by 3 cycles of the same regimen of adjuvant chemotherapy. The control group consisted of 32 patients who underwent surgery alone. The results obtained showed efficacy of the combined modality treatment due to significant decrease in the rate of local recurrences, distant metastases and increase in the rate of overall survival as compared to the group with surgery alone.
About the Authors
Е. L. Yumov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
S. V. Miller
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
N. V. Litvyakov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
National Research Tomsk State University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
Т. V. Polischuk
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
S. А. Tuzikov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Siberian State Medical University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
О. V. Cheremisina
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
V. Е. Goldberg
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
Е. О. Rodionov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Siberian State Medical University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
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Review
For citations:
Yumov Е.L., Miller S.V., Litvyakov N.V., Polischuk Т.V., Tuzikov S.А., Cheremisina О.V., Goldberg V.Е., Rodionov Е.О. CHEMOTHERAPY IN COMBINED MODALITY TREATMENT FOR LOCALLY ADVAMCED NON-SMALL CELL LUNG CANCER. Siberian journal of oncology. 2014;(2):9-13. (In Russ.)
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