CHEMOTHERAPY IN COMBINED MODALITY TREATMENT FOR LOCALLY ADVAMCED NON-SMALL CELL LUNG CANCER
Abstract
The comparative analysis of immediate and long-term clinical outcomes in 68 patients with stage III non-small cell lung cancer was carried out. The study group comprised 36 patients who received 2 cycles of neoadjuvant vinorelbin/carboplatin-containing chemotherapy with subsequent assessment of objective response. If complete and partial responses were achieved and in cases with stable disease, patients underwent radical surgery followed by 3 cycles of the same regimen of adjuvant chemotherapy. The control group consisted of 32 patients who underwent surgery alone. The results obtained showed efficacy of the combined modality treatment due to significant decrease in the rate of local recurrences, distant metastases and increase in the rate of overall survival as compared to the group with surgery alone.
About the Authors
Е. L. Yumov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
S. V. Miller
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
N. V. Litvyakov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
National Research Tomsk State University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
Т. V. Polischuk
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
S. А. Tuzikov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Siberian State Medical University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
О. V. Cheremisina
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
V. Е. Goldberg
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
Е. О. Rodionov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Siberian State Medical University, Tomsk
Russian Federation
12/1 Savinykh Street, 634028-Toms
Russian Federation
12/1 Savinykh Street, 634028-Toms
References
1. Laktionov K.K., Davydov M.I., Polockij B.E., Zborovskaja I.B., Bogatyrev V.N., Nikulichev L.A., Stepanova E.V., Allahverdiev A.K., Ardzinba M.S. Prognostic and predicting factors in patients with non-small cell lung cancer // Prakticheskaja onkologija. 2006. Vol. 7 (3). P. 145–153. [in Russian]
2. Miller S.V., Tuzikov S.A., Gol’dberg V.E., Zav’jalov A.A., Polishhuk T.V., Dobrodeev A.Ju., Jumov E.L., Lobykin A.F. Neoadjuvant chemotherapy with taxanes in combined modality treatment of non-small cell lung cancer // Rossijskij onkologicheskij zhurnal. 2011. № 5. P. 4–8. [in Russian]
3. Trahtenberg A.H., Chissov V.I. Clinical oncopulmonogy. M.: Medicina, 2000. 599 p. [in Russian]
4. Chissov V.I., Starinskij V.V., Petrova G.V. Cancer incidence in Russia in 2011 (morbidity and mortality). M., 2013. 289 p. [in Russian]
5. D’Amato T.A., Landreneau R.J., McKenna R.J., Santos R.S., Parker R.J. Prevalence of in vitro extreme chemotherapy resistance in resected non small-cell lung cancer // Ann. Thorac. Surg. 2006. Vol. 81. P. 440–447. [in Russian]
6. Evans N.R., Li S., Wright C.D., Wright C.D., Allen M.S., Gaissert H.A. The impact of induction therapy on morbidity and operative mortality after resection of primary lung cancer // J. Thorac. Cardiovasc. Surg. 2010. Vol. 139 (4). P. 991–996. doi: 10.1016/j.jtcvs.2009.11.070.
7. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C.D., Parkin D. GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10. Lyon, France: International Agency for Research on Cancer; Year. Available at: http://globocan.iarc.fr. 2010.
8. Gilligan D., Nicolson M., Smith I., Groen H., Dalesio O., Goldstraw P., Hatton M., Hopwood P., Manegold C., Schramel F., Smit H., van Meerbeeck J., Nankivell M., Parmar M., Pugh C., Stephens R. Preoperative chemotherapy in patients with resectable non-small cell lung cancer: results of the MRC LU22/NVaLT2/EORTC 08012 multicentre randomised trial and update of systematic review // Lancet. 2007. Vol. 369. P. 1929–1937.
9. Giuliani J., Piacentini P., Greco F., Mercanti A., Trolese A.R., Furini L., Durante E., Moratello G., Tognetto M., Bonetti A. Carboplatin-containing regimens as front-line treatment for advanced nonsmall-cell lung cancer in two groups of elderly // J. Chemother. 2014. Vol. 26 (2). P. 111–116. doi: 10.1179/1973947813Y.0000000112.
10. Kolek V., Grygarkova I., Hajduch M., Klein J., Cwiertka K., Neoral C., Langova K., Mihal V. Long term follow-up of neoadjuvant-adjuvant combination treatment of IIIA stage non-small-cell-lung cancer: results of neoadjuvant carboplatin/vinorelbine and carboplatin/paclitaxel regimens combined with selective adjuvant chemotherapy according to in-vitro chemoresistance test // Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. 2008. Vol. 152 (2). P. 259–266.
11. Sato Y., Yamamoto N., Kunitoh H., Ohe Y., Minami H., Laird N.M., Katori N., Saito Y., Ohnami S., Sakamoto H., Sawada J., Saijo N., Yoshida T., Tamura T. Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel // J. Thorac. Oncol. 2011. Vol. 6 (1). P. 132–138. doi: 10.1097/ JTO.0b013e318200f415.
12. Scagliotti G.V., Pastorino U., Vansteenkiste J.F., Spaggiari L., Facciolo F., Orlowski T.M., Maiorino L., Hetzel M., Leschinger M., Visseren-Grul C., Torri V. Randomized phase III study of surgery alone or surgery plus preoperative cisplatin and gemcitabine in stages IB to IIIa non-small-cell lung cancer // J. Clin. Oncol. 2012. Vol. 30. P. 172–178. doi: 10.1200/JCO.2010.33.7089.
Review
For citations:
Yumov Е.L., Miller S.V., Litvyakov N.V., Polischuk Т.V., Tuzikov S.А., Cheremisina О.V., Goldberg V.Е., Rodionov Е.О. CHEMOTHERAPY IN COMBINED MODALITY TREATMENT FOR LOCALLY ADVAMCED NON-SMALL CELL LUNG CANCER. Siberian journal of oncology. 2014;(2):9-13. (In Russ.)
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