Relationship between the development of lung squamous cell and grandular carcinoma recurrencesand the character of dysregeneratory changes in bronchial epithelium near the tumor
Abstract
Comparative analysis of the relationship between the character of dysregeneratory changes occurring in the bronchial epithelium adjacent to the tumor and the development of recurrence of squamous cell and grandular carcinomas of the lung was carried out. The study showed no any relationship between such parameters as tumor size, presence of lymphogenic metastasis, tumor stage and tumor recurrences. The incidence of recurrence in non-small cell lung cancer indirectly related to the character of dysregeneratory changes in the respiratory epithelium of the bronchial mucosa outside the tumor. High incidence rates of squamous cell carcinoma and adenocarcinoma of the lung were observed in cases with combination of basal cell hyperplasia and squamous metaplasia (BCH+SM+).
About the Authors
O. V. Pankova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
V. M. Perelmuter
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
E. V. Denisov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
S. A. Tuzikov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
S. V. Miller
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
S. A. Vasilyev
Research Institute of Medical Genetics, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
N. A. Skryabin
Research Institute of Medical Genetics, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
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Review
For citations:
Pankova O.V., Perelmuter V.M., Denisov E.V., Tuzikov S.A., Miller S.V., Vasilyev S.A., Skryabin N.A. Relationship between the development of lung squamous cell and grandular carcinoma recurrencesand the character of dysregeneratory changes in bronchial epithelium near the tumor. Siberian journal of oncology. 2013;1(6):26-30. (In Russ.)
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