Methods of DNa methylation analysis:possibilities and limitations of their application in oncology
Abstract
Abnormalities of DNA methylation play a significant role in initiation and progression of tumors. In this regard it is necessary to study these aberrations in order to better understand the malignant transformation pathogenesis. For this purpose the adequate and objective methods are required. The principles and possibilities of application of basic methods of DNA methylation analysis are reviewed in the paper
About the Authors
N. A. Skryabin
Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
A. A. Kashevarova
Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
E. V. Denisov
Cancer Research Institute, Siberian Branch, Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Skryabin N.A., Kashevarova A.A., Denisov E.V., Lebedev I.N. Methods of DNa methylation analysis:possibilities and limitations of their application in oncology. Siberian journal of oncology. 2013;1(6):64-69. (In Russ.)
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