HEREDITARY CHARACTERISTICS BRCA1 5382INSC/СHEK2/BLM-ASSOCIATED BREAST CANCER
Abstract
The hereditary breast cancer (HBC) occurs in 5–10 % of all cases of breast cancer. The mutations in the genes of high penetrance – BRCA1, BRCA2 is mainly the reason HBC. In the study presented the features of HBC (age of onset of the disease, cancer family history, primary tumor process multiple character). Depending on the presence of mutations BRCA1 5382insC, BLM, CHEK2 carried out a comparative analysis of the occurrence of hereditary characteristics in breast cancer patients.
About the Author
Е. М. Bit-Sava
St-Petersburg State Pediatric Medical Academy
St-Petersburg I.P. Pavlov State Medical University
Russian Federation
2, Litovskaya Srteet, 194100-St-Petersburg
Russian Federation
2, Litovskaya Srteet, 194100-St-Petersburg
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Review
For citations:
Bit-Sava Е.М. HEREDITARY CHARACTERISTICS BRCA1 5382INSC/СHEK2/BLM-ASSOCIATED BREAST CANCER. Siberian journal of oncology. 2014;(6):15-18. (In Russ.)
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