DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD
Abstract
Intestinal mucosa is a barrier, preventing bacteria and it’s derivate from penetrating to organism, where it triggers inflammation. In this study the dynamic of intestinal permeability in cancer and cardio surgery patients during perioperative period is evaluated using dual sugar test (lactulose-mannitol). Lactulose and mannitol excretion ratio is increased in group of cancer patients with postoperative complications before and after surgery. This indicates an increased intestinal permeability in these patients. Probably increased permeability cause bacterial lipopolysaccharide translocation into blood, where it induces effectors of innate immunity, leading to system inflammation reaction due to already activated immunity. According to this, evaluation of intestinal permeability can be considered as a prognostic factor of unfavorable early postoperative period in cancer patients.
About the Authors
A. Yu. Karpenko
N.N. Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
D. S. Tsvetkov
FSBI FSCC FMBA, Moscow
Russian Federation
24, Kashirskoye shosse, 115478-Moscow
Russian Federation
24, Kashirskoye shosse, 115478-Moscow
M. V. Kiselevsky
N.N. Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
References
1. Anisimova N.Ju., Gromova E.G., Kuznecova L.S., Kiselevskij M.V. Prognostic value of lipopolysaccharide and lipopolysaccharide-binding protein serum levels in cancer patients with sepsis // Zhurnal mikrobiologii, jepidemiologii i immunobiologii. 2011. № 2. P. 82–84. [in Russian]
2. Anisimova N.Ju., Gromova E.G., Kuznecova L.S., Kiselevskij M.V. The level of bacterial endotoxin in the blood of cancer patients having postoperative complications // Allergologija i immunologija. 2010. Vol. 11 (4). P. 310–313. [in Russian]
3. Pluzhnikova N.A., Anisimova N.Ju., Ivanov Ju.V., Cvetkov D.S., Nechaev D.S., Soshnikova E.V., Jalbueva T.A., Kiselevskij M.V. Predictors of early postoperative period of patients operated on for tumors of the esophagus and stomach // Rossijskij immunologicheskij zhurnal. 2012. № 4. P. 370–375. [in Russian]
4. Pluzhnikova N.A., Ivanov Ju.V., Cvetkov D.S., Kiselevskij M.V. Prognostic factors for purulent-septic complications in early postoperative period in cancer patients // Rossijskij bioterapevticheskij zhurnal. 2013. № 2. P. 66–66a. [in Russian]
5. Pluzhnikova N.A., Cvetkov D.S., Kiselevskij M.V. The study of cellular immunity for identification of prognostic factors in the treatment of purulent-septic complications in early postoperative period in cancer patients // Rossijskij bioterapevticheskij zhurnal. 2013. № 2. P. 66. [in Russian]
6. Chikileva I.O., Karaulov A.V., Anisimova N.Ju., Kiselevskij M.V. The Dual role of Toll-receptors in regulation of antitumorous immunity // Immunologija. 2010. № 1. P. 52–55. [in Russian]
7. Ando T., Brown R.F., Berg R.D., Dunn A.J. Bacterial translocation can increase plasma corticosterone and brain catecholamine and indoleamine metabolism // Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000. Vol. 279 (6). P. 2164–2172.
8. Capaldo C.T., Nusrat A. Cytokine regulation of tight junctions // Biochim. Biophys. Acta. 2009. Vol. 1788 (4). P. 864–871. doi: 10.1016/j. bbamem.2008.08.027.
9. Corcoran A.C., Page I.H. A method for the determination of mannitol in plasma and urine // Fed. Proc. 1946. № 5. P. 130.
10. Harris C.E., Griffiths R.D., Freestone N., Billington D., Atherton S.T., Macmillan R.R. Intestinal permeability in the critically ill // Intensive Care Med. 1992. Vol. 18 (1). P. 38–41.
11. Miki K., Moore D.J., Butler R.N., Southcott E., Couper R.T., Davidson G.P. The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease // J. Pediatr. 1998. Vol. 133 (6). P. 750–754.
12. Nagpal K., Minocha V.R., Agrawal V., Kapur S. Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis // Am. J. Surg. 2006. Vol. 192 (1). P. 24–28.
13. O’Boyle C.J., MacFie J., Mitchell C.J., Johnstone D., Sagar P.M., Sedman P.C. Microbiology of bacterial translocation in humans // Gut. 1998. Vol. 42 (1). P. 29–35.
14. Papa M., Halperin Z., Rubinstein E., Orenstein A., Gafin S., Adar R. The effect of ischemia of the dog’s colon on transmural migration of bacteria and endotoxin // J. Surg. Res. 1983. Vol. 35 (3). P. 264–269.
15. Sagar P.M., MacFie J., Sedman P., May J., Mancey-Jones B., Johnstone D. Intestinal obstruction promotes gut translocation of bacteria // Dis. Colon Rectum. 1995. Vol. 38 (6). P. 640–644.
16. Travis S., Menzies I. Intestinal permeability: functional assessment and significance // Clin. Sci. (Lond). 1992. Vol. 82 (5). P. 471–488.
17. Winchurch R.A., Thupari J.N., Munster A.M. Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size // Surgery. 1987. Vol. 102 (5). P. 808–812.
Review
For citations:
Karpenko A.Yu., Tsvetkov D.S., Kiselevsky M.V. DYNAMIC OF INTESTINAL PERMEABILITY IN CANCER PATIENTS DURING PERIOPERATIVE PERIOD. Siberian journal of oncology. 2014;(6):27-32. (In Russ.)
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