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SURGICAL RESECTION OF THE PRIMARY TUMOR IN COMBINATION TREATMENT OF PATIENTS WITH STAGE IV BREAST CANCE

https://doi.org/10.21294/1814-4861-2016-15-1-19-25

Abstract

The present paper is devoted to the major treatment modalities for generalized breast cancer. A detailed extensive analysis of recent studies was carried out with the aim to consider whether surgery as a part of multimodality treatment strategy is beneficial for patients with stage IV breast cancer. The study included 196 patients with generalized breast cancer, who were treated at P.A. Gertsen Moscow Oncology Research Institute between 2000 and 2012. All patients were divided into two groups. The first group consisted of 124 patients who underwent surgical resection as a part of multimodality treatment. The second group included 72 patients who received systemic therapy. The factors influencing on the prognosis and life quality of patients with generalized breast cancer, namely: hormone-dependent tumor, Her2/neu hyper-expression, reproductive function status (age, menopause) were also studied.

About the Authors

A. D. Zikiryahodjaev
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia
Russian Federation

MD, DSc, Head of the Department of Oncology and Reconstructive Surgery of the Breast and Skin,

3, 2-nd Botkinsky proezd, 125284-Moscow



L. V. Bolotina
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia
Russian Federation

MD, DSc, Head of Chemotherapy Department,

3, 2-nd Botkinsky proezd, 125284-Moscow



A. S. Sukhotko
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of Russia
Russian Federation

MD, PhD, Researcher, the Department of Oncology and Reconstructive Surgery of the Breast and Skin,

3, 2-nd Botkinsky proezd, 125284-Moscow



References

1. Malignant tumors in Russia in 2013 / Eds. A.D. Kaprin, V.V. Starinskij, G.V. Petrova. М., 2015. 250 с. [in Russian]

2. Pak D.D., Bolotina L.V., Suhotko A.S. Current aspects of comprehensive treatmentfor advanced breast cancer (literature review and analysis of original material) // Sibirskij onkologicheskij zhurnal. 2013. № 5. P. 54–58. [in Russian]

3. Sukhot’ko A.S., Zikiriakhodzhaev A.D., Bolotina L.V., Sidorov D.B., Tyshchenko E.V. A surgical stage in the complex therapy of patients with generalized breast cancer// Onkologija. Zhurnal im. P.A. Gercena. 2014. Vol. 2 (1). P. 24–29. [in Russian]

4. Chissov V.I., Solodkiĭ V.A., Pak D.D., Rozhkova N.I., Ermoshchenkova M.V., Kireeva M.N. Breast cancer screening: history and prospects // Onkologija. Zhurnal im. P.A. Gercena. 2013. № 2. P. 46–51. [in Russian]

5. Andreopoulou E., Hortobagyi G.N. Prognostic factors in metastatic breast cancer: successes and challenges toward individualized therapy // J. Clin. Oncol. 2008. Vol. 26 (22). P. 3660–3662. doi: 10.1200/JCO.2008.16.1026.

6. Babiera G.V., Rao R., Feng L., Meric-Bernstam F., Kuerer H.M., Singletary S.E., Hunt K.K., Ross M.I., Gwyn K.M., Feig B.W., Ames F.C., Hortobagyi G.N. Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor // Ann. Surg. Oncol. 2006. Vol. 13 (6). P. 776–782.

7. Bafford A.C., Burstein H.J., Barkley C.R., Smith B.L., Lipsitz S., Iglehart J.D., Winer E.P., Golshan M. Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival // Breast Cancer Res. Treat. 115 (1). Vol. 2009. P. 7–12. doi: 10.1007/s10549-008-0101-7.

8. Baum M., Demicheni R., Hrushesky W., Retsky M. Does surgery unfavourably perturb the «natural history» of early breast cancer by accelerating the appearance of distant metastases? // Eur. J. Cancer. 2005. Vol. 41 (4). P. 508–515.

9. Bernard-Marty C., Cardoso F., Piccart M.J. Facts and controversies in systemic treatment of metastatic breast cancer // Oncologist. 2004. Vol. 9 (6). Р. 617–632.

10. Blanchard D.K., Shetty P.B., Hilsenbeck S.G., Elledge R.M. Association of surgery with improved survival in stage IV breast cancer patients // Ann. Surg. 2008. Vol. 247 (5). P. 732–738. doi: 10.1097/SLA.0b013e3181656d32.

11. Burzykowski T., Buyse M., Piccart-Gebhart M.J., Sledge G., Carmichael J., Lück H.J., Mackey J.R., Nabholtz J.M., Paridaens R., Biganzoli L., Jassem J., Bontenbal M., Bonneterre J., Chan S., Basaran G.A., Therasse P. Evaluation of tumor response, disease control, progressionfree survival, and time to progression as potential surrogate end points in metastatic breast cancer // J. Clin. Oncol. Vol. 2008. 26 (12). P. 1987–1992. doi: 10.1200/JCO.2007.10.8407.

12. Cady B., Nathan N.R., Michaelson J.S., Golshan M., Smith B.L. Matched pair analyses of stage IV breast cancer with or without resection of primary breast site // Ann. Surg. Oncol. 2008. Vol. 15 (12). P. 3384–3395. doi: 10.1245/s10434-008-0085-x.

13. Coffey J.C., Wang J.H., Smith M.J., Bouchier-Hayes D., Cotter T.G., Redmond H.P. Excisional surgery for cancer cure. Therapy at a cost // Lancet Oncol. 2003. Vol. 4 (12). P. 760–768.

14. Field R.C., Jeffe D.B., Trinkaus K., Zhang Q., Arthur C., Aft R., Dietz J.R., Eberlein T.J., Gillanders W.E., Margenthaler J.A. Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site metastasis // Ann. Surg. Oncol. 2007. Vol. 14 (12). P. 3345–3351.

15. Gnerlich J., Jeffe D.B., Deshpande A.D., Beers C., Zander C., Margenthaler J.A. Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER data // Ann. Surg. Oncol. 2007. Vol. 14 (8). P. 2187–2194.

16. Hazard H.W., Gorla S.R., Scholtens D., Kiel K., Gradishar W.J., Khan S.A. Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer // Cancer. 2008. Vol. 113 (8). P. 2011–2019.

17. Khan S.A. Does resection of an intact breast primary improve survival in metastatic breast cancer? // Oncology. 2007. Vol. 21 (8). P. 924–931.

18. Lang J.E., Babiera G.V. Locoregional resection in stage IV breast cancer tumor biology, molecular and clinical perspectives // Surg. Clin. North Am. 2007. Vol. 87 (2). P. 527–538.

19. Leung A.M., Vu H.N., Nguyen K.A., Thacker L.R., Bear H.D. Effects of surgical excision on survival of patients with stage IV breast cancer // J. Surg. Res. 2010. Vol. 161 (1). P. 161–183. doi: 10.1016/j.jss.2008.12.030.

20. Lopez-Tarruella S., Puente J., Lluch A., Climent M., Pastor M., Alba E. Impact on survival of primary tumor resection in woman with metastatic breast cancer at initial diagnosis. The Alamo Project // Cancer Res. 2009. Vol. 69 (24 Suppl.). P. 3104. doi: 10.1158/0008-5472.SABCS-09-3104.

21. Ly B.H., Nguyen N.P., Vinh-Hung V., Rapiti E., Vlastos G. Locoregional treatment in metastatic breast cancer patients: is there a survival benefit? // Breast Cancer Res. Treat. 2010. Vol. 119 (3). P. 537–545.

22. Olson J.A., Marcom P.K. Benefit or bias? The role of surgery to remove the primary tumor in patients with metastatic breast cancer // Ann. Surg. 2008. Vol. 247 (5). P. 739–740. doi: 10.1097/SLA.0b013e3181706140.

23. Rao R., Feng L., Kuerer H.M., Singletary S.E., Bedrosian I., Hunt K.K., Ross M.I., Hortobagyi G.N., Feig B.W., Ames F.C., Babiera G.V. Timing of surgical intervention for the intact primary in stage IV breast cancer patients // Ann. Surg. Oncol. 2008. Vol. 15 (6). P. 1696–1702. doi: 10.1245/s10434-008-9830-4.

24. Rapiti E., Verkooijen H.M., Vlastos G., Fioretta G., NeyroudCaspar I., Sappino A.P., Chappuis P.O., Bouchardy C. Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis // J. Clin. Oncol. 2006. Vol. 24 (18). P. 2743–2749.

25. Ruiterkamp J., Ernst M.F., van de Poll-Franse L.V., Bosscha K., Tjan-Heijnen V.C., Voogd A.C. Surgical resection of the primary tumor is associated with improved survival in patients with distant metastatic breast cancer at diagnosis // Eur.J. Surg. Oncol. 2009. Vol. 35 (11). P. 1146–1151. doi: 10.1016/j.ejso.2009.03.012.

26. Shien T., Kinoshita T., Shimizu C., Hojo T., Taira N., Doihara H., Akashi-Tanaka S. Primary tumor resection improves the survival of younger patients with metastatic breast cancer // Oncol. 2009. Vol. 21 (3). P. 827–832.

27. Sinha P., Clements V.K., Miller S., Ostrand-Rosenberg S. Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression // Cancer Immunol. Immunother. 2005. Vol. 54 (11). P. 1137–1142.

28. Soran A., Ozbas S., Kelsey S.F., Gulluoglu B.M. Randomized trial comparing locoregional resection of primary tumor with no surgery in stage IV breast cancer at the presentation (ProtocolMF07-01): a study of Turkish Federation of the National Societies for Breast Diseases // Breast J. 2009. Vol. 15 (4). P. 399–403.


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For citations:


Zikiryahodjaev A.D., Bolotina L.V., Sukhotko A.S. SURGICAL RESECTION OF THE PRIMARY TUMOR IN COMBINATION TREATMENT OF PATIENTS WITH STAGE IV BREAST CANCE. Siberian journal of oncology. 2016;15(1):19-25. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-1-19-25

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ISSN 1814-4861 (Print)
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