Pancreatic ductual carcinoma with isolated liver metastases: is it worth performing surgical resection?
https://doi.org/10.21294/1814-4861-2024-23-5-126-132
Abstract
Pancreatic ductal cancer is one of the most aggressive malignancy with a high incidence of advanced stages at the time of diagnosis and unsatisfactory long-term treatment results. It is believed that pancreatic ductal cancer in the presence of distant metastases identified at the stage of intraoperative revision or before surgery is a contraindication to surgical treatment. There is currently renewed interest in surgical treatment of patients with oligometastatic pancreatic cancer.
Material and Methods. The search for sources was carried out in the PubMed and Elibrary systems from January 1995 to January 2024. Of the 1321 sources found, 37 were used to write the review. Data from both retrospective and prospective clinical studies that focused on the results of combined modality treatment of pancreatic cancer with isolated liver metastases were included.
Results. To date, a standard treatment strategy for patients with oligometastatic pancreatic cancer has not yet been established; there are no definitive criteria for selecting patients who may benefit from surgical treatment. The current selection criteria for surgery for metastatic pancreatic cancer are far from ideal, extremely heterogeneous and, as a rule, are based only on certain clinical and instrumental data. The starting point for developing selection criteria for surgical treatment of patients with metastatic pancreatic cancer is a common understanding of what “oligometastatic pancreatic cancer” is.
About the Authors
V. I. Egorov
Kazan State Medical University of the Ministry of Health of Russia;
Tatarstan Regional Clinical Cancer Center of the Ministry of Health of the Republic of Tatarstan
Russian Federation
Russian Federation
Vasily I. Egorov, MD, PhD, Assistant, Department of Oncology, Radiation Therapy and Diagnostic Imaging, 49, Butlerov St., Kazan, 420012;
Oncologist, Department of Oncology, 29, Sibirsky trakt, Kazan, 420029
A. G. Kotelnikov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Alexey G. Kotelnikov, MD, DSc, Professor, Leading Researcher, Department of Abdominal Oncology No. 2,
23, Kashirskoye shosse, Moscow, 115522
D. M. Kantieva
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Dayana M. Kantieva, MD, Oncologist, 2-nd Chemotherapy Department,
23, Kashirskoye shosse, Moscow, 115522
I. S. Bazin
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Russian Federation
Russian Federation
Igor S. Bazin, MD, DSc, Leading Researcher, 2-nd Chemotherapy Department,
23, Kashirskoye shosse, Moscow, 115522
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Review
For citations:
Egorov V.I., Kotelnikov A.G., Kantieva D.M., Bazin I.S. Pancreatic ductual carcinoma with isolated liver metastases: is it worth performing surgical resection? Siberian journal of oncology. 2024;23(5):126-132. (In Russ.) https://doi.org/10.21294/1814-4861-2024-23-5-126-132
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