Orbital metastases from breast cancer: three case reports
L. A. Danilova,
E. P. Anokhina,
E. A. Toneev,
R. F. Shagdaleev,
A. M. Ponomarenko,
D. V. Glumnushina,
N. D. Krymzalova https://doi.org/10.21294/1814-4861-2024-23-5-185-191
Abstract
Purpose: to describe rare cases of orbital metastases from breast cancer.
Material and Methods. Three cases of Luminal A(1) and B(2) breast cancer with orbital metastases were identified and studied during the period from 01.01.2018 to 01.05.2024. Metastasis to the orbit was detected 5, 2 and 1.5 years after radical mastectomy for breast cancer. Patients received chemotherapy and radiation therapy.
Results. Cases of orbital metastasis originating from breast cancer were found to have a low frequency, but may be associated with a long period between cancer diagnosis and initiation of treatment. Early detection of breast cancer and its active treatment with chemotherapy and radiation therapy are important factors in preventing orbital metastasis.
Conclusion. A routine follow-up surveillance after radical treatment of breast cancer is important because there is an increase risk of developing orbital metastasis. Comprehensive strategies for treating breast cancer metastases can provide long-term disease control.
About the Authors
L. A. Danilova
Regional Clinical Oncology Center;
Ulyanovsk State University
Russian Federation
Russian Federation
Lyudmila A. Danilova, MD, PhD, Deputy Chief Physician, 90, 12 September St., Ulyanovsk, 4320171;
Associate Professor, Department of Oncology and Diagnostic Imaging, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, 42, Lev Tolstoy St., Ulyanovsk, 432017
E. P. Anokhina
Regional Clinical Oncology Center
Russian Federation
Russian Federation
Ekaterina P. Anokhina, MD, Oncologist, Chemotherapy Department No. 1,
90, 12 September St., Ulyanovsk, 4320171
E. A. Toneev
Regional Clinical Oncology Center;
Ulyanovsk State University
Russian Federation
Russian Federation
Evgeny A. Toneev, MD, PhD, Thoracic Surgeon, Thoracic Oncology Department, 90, 12 September St., Ulyanovsk, 4320171;
Associate Professor, Department of Faculty Surgery, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, 42, Lev Tolstoy St., Ulyanovsk, 432017
R. F. Shagdaleev
Ulyanovsk State University
Russian Federation
Russian Federation
Roman F. Shagdaleev, MD, Resident, Department of Hospital Surgery, Anesthesiology, Resuscitation, Urology, Traumatology and Orthopedics, Faculty of Dentistry, Pharmacy and Postgraduate Medical Education, Institute of Medicine, Ecology and Physical Culture,
42, Lev Tolstoy St., Ulyanovsk, 432017
A. M. Ponomarenko
Regional Clinical Oncology Center
Russian Federation
Russian Federation
Anna M. Ponomarenko, MD, Radiologist, X-ray Diagnostics Department,
90, 12 September St., Ulyanovsk, 4320171
D. V. Glumnushina
Ulyanovsk State University
Russian Federation
Russian Federation
Daria V. Glumnushina, Student, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture,
42, Lev Tolstoy St., Ulyanovsk, 432017
N. D. Krymzalova
Ulyanovsk State University
Russian Federation
Russian Federation
Natalia D. Krymzalova, Student, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture,
42, Lev Tolstoy St., Ulyanovsk, 432017
References
1. Wilkinson L., Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022; 95(1130). doi: 10.1259/bjr.20211033.
2. CANCER IN RUSSIA AND WORLDWIDE. Monitoring and expert studies: know and defeat cancer. Issue 55. Superviser: Z.A. Saidova; editor-inchief: A.I. Komarova. Vol. 846(888). Moscow, 2022. 19 p. (in Russian).
3. Saad E.S.P., Bakri H.M., Rayan A., Barakat D., Khalel M.M. Eye metastasis in breast cancer: case report and review of literature. Ecancermedicalscience. 2022; 16: 1353. doi: 10.3332/ecancer.2022.1353.
4. Malignant tumors in Russia in 2020 (morbidity and mortality). Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow, 2021. 252 p. (in Russian).
5. Nelson C.C., Hertzberg B.S., Klintworth G.K. A histo-pathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol. 1983; 95(6): 788–93. doi: 10.1016/0002-9394(83)90066-1.
6. Eliassi-Rad B., Albert D.M., Green W.R. Frequency of ocular metastases in patients dying of cancer in eye bank populations. Br J Ophthalmol. 1996; 80(2): 125–8. doi: 10.1136/bjo.80.2.125.
7. Grishina E.E. Ocular metastases. RMJ. Clinical Ophthalmology. 2001; 2(1): 15–17. (in Russian).
8. Pierson T.M., Tebit E.V., El Sayed A., Smolkin M.E., Dillon P.M. Orbital Metastases from Breast Cancer: Retrospective Analysis at an Academic Cancer Center. Breast J. 2016; 22(4): 447–50. doi: 10.1111/tbj.12604.
9. Grajales-Alvarez R., Gutierrez-Mata A. Orbital metastases from breast cancer: A retrospective analysis of 28 cases. Cancer Treat Res Commun. 2020. doi: 10.1016/j.ctarc.2020.100184.
10. Aralikatti D.A., Nylander A.G. Orbital metastasis from squamous cell carcinoma of the esophagus. Eur J Ophthalmol. 2006; 16(3): 458–60. doi: 10.1177/112067210601600316.
11. González F., López-Couto C. Metástasis orbitarias. Serie de cuatro casos y revisión de la literatura [Orbital metastases. A report of four cases and a review of the literature]. Arch Soc Esp Oftalmol. 2006; 81(8): 451–62. Spanish. doi: 10.4321/s0365-66912006000800006.
12. Freedman M.I., Folk J.C. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 1987; 105(9): 1215–9. doi: 10.1001/archopht.1987.01060090073031.
13. Schick U., Lermen O., Hassler W. Management of orbital metastases. Zentralbl Neurochir. 2006; 67(1): 1–7. doi: 10.1055/s2005-836922.
14. Shields J.A., Shields C.L., Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004; 111(5): 997–1008. doi: 10.1016/j.ophtha.2003.01.002.
15. Günalp I., Gündüz K. Metastatic orbital tumors. Jpn J Ophthalmol. 1995; 39(1): 65–70.
16. Holland D., Maune S., Kovács G., Behrendt S. Metastatic tumors of the orbit: a retrospective study. Orbit. 2003; 22(1): 15–24. doi: 10.1076/orbi.22.1.15.14007.
Review
For citations:
Danilova L.A., Anokhina E.P., Toneev E.A., Shagdaleev R.F., Ponomarenko A.M., Glumnushina D.V., Krymzalova N.D. Orbital metastases from breast cancer: three case reports. Siberian journal of oncology. 2024;23(5):185-191. (In Russ.) https://doi.org/10.21294/1814-4861-2024-23-5-185-191
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