GASTRIC CANCER: MOLECULAR AND GENETIC DATA (LITERATURE REVIEW)
Abstract
In the review a data about molecular and genetic aspects of different morphological variants of gastric cancer in population and family studies are generalized. Data about multiple genetic and epigenetic damages in oncogenes, tumor suppressor genes, cell cycle regulators, adhesion molecules, DNA repair genes as well as genetic instability and telomerase activation involved in the multistep process of carcinogenesis and making a contribution to uncontrolled growth and ability to form metastases are included in the review. In article possibilities of use of specific molecular markers for early GC diagnostics are discussed.
About the Authors
A. V. Belkovets
Institute of Internal and Prophylactic Medicine of SB RAMS, Novosibirsk
Russian Federation
Russian Federation
O. V. Reschetnikov
Institute of Internal and Prophylactic Medicine of SB RAMS, Novosibirsk
Russian Federation
Russian Federation
S. A. Kurilovich
Institute of Internal and Prophylactic Medicine of SB RAMS, Novosibirsk
Novosibirsk State Medical University, Novosibirsk, Russian Federation2
Russian Federation
175/1, B. Bogatkova st., 630089-Novosibirsk
Russian Federation
175/1, B. Bogatkova st., 630089-Novosibirsk
V. N. Maksimov
Institute of Internal and Prophylactic Medicine of SB RAMS, Novosibirsk
Russian Federation
Russian Federation
References
1. Beljavskaja V.A., Vardosanidze V.K., Smirnova O.Ju., Karakin E.I., Savkin I.V., Gervas P.A., Cherdynceva N.V., Voevoda M.I. Genetic status of p53 in stomach cancer: Somatic mutations and polymorphism of codon 72 // Bjulleten’ jeksperimental’noj biologii i mediciny. 2006. № 2. P. 205–209. [in Russian]
2. Davydov M.I., Aksel’ E.M. Cancer incidence among the population of Russia and the CIS countries in 2006 // Vestnik RONC im. N.N. Blohina RAMN. 2008. Vol. 19 (2). Suppl. 1. P. 52–90. [in Russian]
3. Davydov M.I., Ter-Ovanesov M.D. Current strategy of surgical treatment for gastric cancer // Sovremennaja onkologija. 2000. Vol. 2 (1). P. 4–10. [in Russian]
4. Zaridze D.G. Epidemiology and etiology of cancer. Carcinogenesis. M.: Nauchnyj mir, 2000. P. 26–30; 34–56. [in Russian]
5. Stepanov I.V., Zav‘jalova M.V., Grigor‘eva E.S., Bukurova Ju.A., Afanas‘ev S.G., Cherdynceva N.V. Clinical-morphological and moleculargenetic characteristics of intestinal and diffuse types of gastric carcinomasa // Sibirskij onkologicheskij zhurnal. 2010. № 4. P. 55–66. [in Russian]
6. Anagnostopoulos G.K., Stefanou D., Arkoumani E., Chalkley L., Karagiannis J., Paraskeva K., Mathou N., Dellaporta E., Tsianos E., Agnantis N.J. Expression of Bax protein in gastric carcinomas. A clinicopathological and immunohistochemical study // Acta. Gastroenterol. Belg. 2007. Vol. 70. P. 285–289.
7. Bamias A.T., Bai M.C., Agnantis N.J., Michael M.C., Alamanos Y.P., Stefanaki S.V., Razi E.D., Skarlos D.V., Kappas A.M., Pavlidis N.A. Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma // Cancer Invest. 2003. Vol. 21. P. 333–340.
8. Becker K.F., Keller G., Hoefler H. The use of molecular biology in diagnosis and prognosis of gastric cancer // Surg. Oncol. 2000. Vol. 9. P. 5–11.
9. Boland C.R., Thibodeau S.N., Hamilton S.R., Sidransky D., Eshleman J.R., Burt R.W., Meltzer S.J., Rodriguez-Bigas M.A., Fodde R., Ranzani G.N., Srivastava S. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer // Cancer Res. 1998. Vol. 58. P. 5248–5257.
10. Buffart T.E., Overmeer R.M., Steenbergen R.D., Tijssen M., van Grieken N.C., Snijders P.J., Grabsch H.I., van de Velde C.J., Carvalho B., Meijer G.A. MAL promoter hypermethylation as a novel prognostic marker in gastric cancer // Br. J. Cancer. 2008. Vol. 99. P. 1802–1807. doi: 10.1038/sj.bjc.6604777.
11. Buffart T.E., van Grieken N.C., Tijssen M., Coffa J., Ylstra B., Grabsch H.I., van de Velde C.J., Carvalho B., Meijer G.A. High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers // Virchows Arch. 2009. Vol. 455. P. 213–223. doi: 10.1007/s00428-009-0814-y.
12. Cancer incidence in five continents. IARC Press. 1996.
13. Corso G., Pedrazzani C., Marrelli D., Pascale V., Pinto E., Roviello F. Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma // Arch. Surg. 2009. Vol. 144. P. 722–727. doi: 10.1001/archsurg.2009.42.
14. Goldgar D.E., Easton D.F., Cannon-Albright L.A., Skolnick M.H. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands // J. Natl. Cancer Inst. 1994. Vol. 86. P. 1600–1608.
15. Guilford P., Hopkins J., Harraway J., McLeod M., McLeod N., Harawira P., Taite H., Scoular R., Miller A., Reeve A.E. E-cadherin germline mutations in familial gastric cancer // Nature. 1998. Vol. 392. P. 402–405.
16. Hsu P.I., Hsieh H.L., Lee J., Lin L.F., Chen H.C., Lu P.J., Hsiao M. Loss of RUNX3 expression correlates with differentiation, nodal metastasis, and poor prognosis of gastric cancer // Ann. Surg. Oncol. 2009. Vol. 16. Vol. 1686–1694. doi: 10.1245/s10434-009-0428-2.
17. Iacopetta B.J., Soong R., House A.K., Hamelin R. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes // J. Pathol. 1999. Vol. 187. P. 428–432.
18. Imai K., Yamamoto H. Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics // Carcinogenesis. 2008. Vol. 29. P. 673–680.
19. Kim M.S., Kim S.S., Ahn C.H., Yoo N.J., Lee S.H. Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability // Hum. Pathol. 2009. Vol. 40. P. 58–64. doi: 10.1016/j.humpath.2008.06.006.
20. Kouraklis G., Katsoulis I.E., Theocharis S., Tsourouflis G., Xipolitas N., Glinavou A., Sioka C., Kostakis A. Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma? // Dig. Dis. Sci. 2009. Vol. 54. P. 1015–1020. doi: 10.1007/s10620-008-0464-y.
21. La Vecchia C., Negri E., Franceschi S., Gentile A. Family history and the risk of stomach and colorectal cancer // Cancer. 1992. Vol. 70. P. 50–55.
22. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification // Acta Pathol. Microbiol. Scand. 1965. Vol. 64. P. 31–49.
23. Lazar D., Taban S., Ardeleanu C., Simionescu C., Sporea I., Cornianu M., Vernic C. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients’ survival // Rom. J. Morphol. Embryol. 2008. Vol. 49. P. 371–379.
24. Lee H.K., Lee H.S., Yang H.K. Prognostic significance of Bcl-2 and p53 expression in gastric cancer // Int. J. Colorectal. Dis. 2003. Vol. 18. P. 518–525.
25. Leung W.K., To K.F., Chu E.S., Chan M.W., Bai A.H., Ng E.K., Chan F.K., Sung J.J. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer // Br. J. Cancer. 2005. Vol. 92. P. 2190–2194.
26. Liu F., Pan K., Zhang X., Zhang Y., Zhang L., Ma J., Dong C., Shen L., Li J., Deng D., Lin D., You W. Genetic variants in cyclooxygenase-2, expression and risk of gastric cancer and its precursors in a Chinese population // Gastroenterology. 2006. Vol. 130. P. 1975–1984.
27. Liu X.P., Tsushimi K., Tsushimi M., Tsushimi M., Oga A., Kawauchi S., Furuya T., Sasaki K. Expression of p53 protein as a prognostic indicator of reduced survival time in diffuse-type gastric carcinoma // Pathol. Int. 2001. Vol. 51. P. 440–444.
28. Ono H., Kondo H., Gotoda T., Shirao K., Yamaguchi H., Saito D., Hosokawa K., Shimoda T., Yoshida S. Endoscopic mucosal resection for treatment of early gastric cancer // Gut. 2001. Vol. 48. P. 225–229.
29. Otsubo T., Akiyama Y., Yanagihara K., Yuasa Y. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cellcycle arrest and apoptosis // Br. J. Cancer. 2008. Vol. 98. P. 824–831. doi: 10.1038/sj.bjc.6604193.
30. Ottini L., Falchetti M., Saieva C., De Marco M., Masala G., Zanna I., Paglierani M., Giannini G., Gulino A., Nesi G., Mariani Costantini R., Palli D. MRE11 expression is impaired in gastric cancer with microsatellite instability // Carcinogenesis. 2004. Vol. 25. P. 2337–2343.
31. Palli D., Galli M., Caporaso N.E., Cipriani F., Decarli A., Saieva C., Fraumeni J.F. Jr., Buiatti E. Family history and risk of stomach cancer in Italy // Cancer Epidemiol. Biomarkers Prev. 1994. Vol. 3. P. 15–18.
32. Sanz-Ortega J., Steinberg S.M., Moro E., Saez M., Lopez J.A., Sierra E., Sanz-Esponera J., Merino M.J. Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer // Histol. Histopathol. 2000. Vol. 15. P. 455–462.
33. Scartozzi M., Galizia E., Freddari F., Berardi R., Cellerino R., Cascinu S. Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches // Cancer Treat. Rev. 2004. Vol. 30. P. 451–459.
34. Schlemper R.J., Kato Y., Stolte M. Review of histological classifications of gastrointestinal epithelial neoplasia: differences in diagnosis of early carcinomas between Japanese and Western pathologists // J. Gastroenterol. 2001. Vol. 36. P. 445–456.
35. Shi H., Xu J.M., Hu N.Z., Xie H.J. Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma // World J. Gastroenterol. 2003. Vol. 9. P. 1421–1426.
36. Simpson A.J., Caballero O.L., Pena S.D. Microsatellite instability as a tool for the classification of gastric cancer // Trends Mol. Med. 2001. Vol. 7. P. 76–80.
37. Sugai T., Habano W., Jiao Y.F., Suzuki M., Takagane A., Nakamura S. Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers // Oncology. 2005. Vol. 68. P. 548–557.
38. Tahara E. Genetic pathways of two types of gastric cancer // IARC Sci. Publ. 2004. P. 327–349.
39. Toyokawa T., Yashiro M., Hirakawa K. Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma // Oncol. Rep. 2009. Vol. 21. P. 875–880.
40. Tsugawa K., Yonemura Y., Hirono Y., Fushida S., Kaji M., Miwa K., Miyazaki I., Yamamoto H. Amplification of the c-met, c-erbB-2 and epidermal growth factor receptor gene in human gastric cancers: correlation to clinical features // Oncology. 1998. Vol. 55. P. 475–481.
41. Ushijima T., Sasako M. Focus on gastric cancer // Cancer Cell. 2004. Vol. 5. P. 121–125.
42. Vidal O., Metges J.P., Elizalde I,. Valentíni M., Volant A., Molina R., Castells A., Pera M. High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer // Br. J. Surg. 2009. Vol. 96. P. 1443–1451. doi: 10.1002/bjs.6780.
43. Watson P., Lynch H.T. Extracolonic cancer in hereditary nonpolyposis colorectal cancer // Cancer. 1993. Vol. 71. P. 677–85.
44. Wynford D., Thomas J., Blaydes J. The influence of cell context on the selection pressure for p53 mutation in human cancer // Carcinogenesis. 1998. Vol. 191. P. 29–36.
45. Yu J., Cheng Y.Y., Tao Q., Lam C.N., Geng H., Tian L.W., Wong Y.P., Tong J.H., Ying J.M., Jin H., To K.F., Chan F.K., Sung J.J. Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer // Gastroenterology. 2009. Vol. 136. P. 640–651. doi: 10.1053/j.gastro.2008.10.050.
46. Zhang X.L., Yang Y.S., Xu D.P., Qu J.H., Guo M.Z., Gong Y., Huang J. Comparative study on overexpression of HER2/neu and HER3 in gastric cancer // World J. Surg. 2009. Vol. 33. P. 2112–2118. doi: 10.1007/ s00268-009-0142-z.
47. Zhao P., Liu W., Lu Y.L. Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients // World J. Gastroenterol. 2005. Vol. 11. P. 5735–5738.
48. Zheng H., Takahashi H. Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray // J. Clin. Pathol. 2007. Vol. 60. P. 273–277.
Review
For citations:
Belkovets A.V., Reschetnikov O.V., Kurilovich S.A., Maksimov V.N. GASTRIC CANCER: MOLECULAR AND GENETIC DATA (LITERATURE REVIEW). Siberian journal of oncology. 2014;(2):56-64. (In Russ.)
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