Surgical treatment of local renal cell carcinoma recurrence. Surgical aspects and oncological results
M. Ya. Gaas,
A. D. Kaprin,
A. A. Kostin,
M. V. Epifanova,
N. V. Vorobyev,
R. O. Inozemtsev,
A. S. Kalpinsky,
S. A. Guskova,
N. A. Sorochinskiy https://doi.org/10.21294/1814-4861-2025-24-1-15-28
Abstract
Introduction. Treatment of local RCC recurrence is a serious surgical and therapeutic problem. There is no single standard strategy for the treatment of locally recurrent RCC. Objective: to evaluate the short- and long-term results of surgical treatment of patients with local RCC recurrence. Material and methods. Among all participants (n=53), 48 patients had isolated local RCC recurrence (group 1), and 5 had synchronous metastases (group 2). All patients had one or more local foci of RCC and underwent radical removal of all foci from may 2007 to January 2024. In distant metastases, metastasectomy was performed. Results. Laparotomy was the preferred access (75.4 %). The average duration of surgery was 167.5 minutes in group 1 and 300 minutes in group 2 (p=0.008). In the early postoperative period, 10 people had postoperative complications. The median follow-up period was 68.17 ± 9.17 (95 % CI 17.00; 112.50) months in group 1 and 79.60 ± 12.17 (95 % CI 47.50; 123.50) in group 2 (p=0.493). The median RFS in group 1 was 139.86 ± 11.02 (95 % CI 119.00; 154.50) months and 100.67 ± 10.22 (95 % CI 91.00; 121.00) months in group 2 (p=0.375), while the local RFS was 174.80 ± 12.22 (95 % ci 139.00; 194.50) and 126.00 ± 11.40 (95 % CI 109.20; 142.40) months in groups 1 and 2, respectively (p=0.352). The median PFS was 193.00 ± 11.22 (95 % ci 172.02; 209.50) months in group 1 and 121.13 ± 11.14 (95 % CI 111.00; 146.43) months in group 2 (p=0.266). The median OS was 149.70 ± 11.20 (95 % CI 123.12; 161.43) months in the group 1 and 56.50 ± 11.20 (95 % CI 33.20; 78.42) months in the group 2 (p=0.169). The 5-year CSS was 85.7 % in group 1 and 40 % in group 2 (p=0.096). The 10-year CSS rate was 81 % and 4 % in groups 1 and 2, respectively (p=0.109). Conclusion. Surgical intervention is effective treatment for local recurrence, providing good oncological outcomes; however, size and proximity to neighboring organs can significantly impact the risk of perioperative complications.
About the Authors
M. Ya. Gaas
RUDN University
Russian Federation
Russian Federation
Margarita Ya. Gaas - MD, Postgraduate, Department of Urology and Operative Nephrology with the course of oncourology, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
Researcher ID (WOS) AGH-3315-2022, Author ID (Scopus) 57204283122
A. D. Kaprin
RUDN University; National Medical Research Radiological Centre of the Ministry of Health of Russia; P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of The Ministry of Health of Russia
Russian Federation
Russian Federation
Andrey D. Kaprin - MD, Professor, Academician of Russian Academy of Sciences, Corresponding Member of the Russian Academy of Sciences, General Director, National Medical Research Center of Radiology; Director, Moscow P.A. Hertzen Cancer Research Center – branch of National Medical Research Center of Radiology; Professor of the Department of Urology and Operative Nephrology with the course of oncourology of the faculty of medicine, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198; 4, Koroleva St., Obninsk, 249036; 3, 2nd Botkinsky Drive, Moscow, 125284
Researcher ID (WOS) K-1445-2014, Author ID (Scopus) 6602709853
A. A. Kostin
RUDN University
Russian Federation
Russian Federation
Andrey A. Kostin - MD, DSc, Professor, Corresponding Member, Russian Academy of Sciences, First Vice-Rector for research, Head of Department of Urology and Operative Nephrology with course of Oncourology, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
M. V. Epifanova
RUDN University
Russian Federation
Russian Federation
Maya V. Epifanova - MD, DSc, Specialist in the field of research, design and advanced technologies regenerative medicine in urology and andrology, Professor, Department of Urology and Surgical Neurology in the course of oncourology at the Russian Medical Institute, Professor, Department of Urology with courses in oncology, radiology and andrology of the Faculty of Scientific and Medical Education, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
Author ID (Scopus) 57041195800
N. V. Vorobyev
P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of The Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University of The Ministry of Health of Russia
Russian Federation
Russian Federation
Nikolay V. Vorobyev - MD, PhD, Head of Urology Department, P.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia; Urologist, Associate Professor, Department of Oncology, Radiotherapy and Plastic Surgery, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia.
3, 2nd Botkinsky Drive, Moscow, 125284; 8/2, Trubetskaya St., Moscow, 119991
R. O. Inozemtsev
RUDN University
Russian Federation
Russian Federation
Roman O. Inozemtsev - MD, Urologist, Resident of Department Urology and Operative Nephrology with the course of oncourology, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
Researcher ID (WOS) KYR-4883-2024
A. S. Kalpinsky
P.A. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of The Ministry of Health of Russia
Russian Federation
Russian Federation
Aleksey S. Kalpinsky - MD, PhD, Head of the Surgical Department, P.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia.
3, 2nd Botkinsky Drive, Moscow, 125284
Researcher ID (WOS) E-9698-2014, Author ID (Scopus) 57192806201
S. A. Guskova
RUDN University
Russian Federation
Russian Federation
Sofya A. Guskova - Student, Department Urology and Operative Nephrology with the course of oncourology, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
N. A. Sorochinskiy
RUDN University
Russian Federation
Russian Federation
Nikita A. Sorochinskiy - Student, Department Urology and Operative Nephrology with the course of oncourology, RUDN University.
6, Miklukho-Maklaya St., Moscow, 117198
Researcher ID (WOS) KYR-3013-2024
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For citations:
Gaas M.Ya., Kaprin A.D., Kostin A.A., Epifanova M.V., Vorobyev N.V., Inozemtsev R.O., Kalpinsky A.S., Guskova S.A., Sorochinskiy N.A. Surgical treatment of local renal cell carcinoma recurrence. Surgical aspects and oncological results. Siberian journal of oncology. 2025;24(1):15-28. https://doi.org/10.21294/1814-4861-2025-24-1-15-28
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