A global bibliometric analysis of the scientifc landscape and collaborative networks in prostate cancer and bioinformatics research

Background. Prostate cancer is a leading malignancy among men worldwide, presenting signifcant public health challenges due to its complex biology and diverse clinical outcomes. Recent advances in bioinformatics have greatly infuenced cancer research by enabling the integration of multiple disciplines and improving the analysis of biological data.
Objective. To present a comprehensive bibliometric analysis summarizing global research trends in prostate cancer and bioinformatics from 1998 to 2025.
Material and Methods. A bibliometric study was conducted analyzing 3,426 articles sourced from 961 publications. Data on research output, collaboration patterns, citation impact, and thematic clusters were extracted and analyzed.
Results. The feld exhibited a robust annual growth rate of 18.42 %, with an average document age of 5.65 years and 26.34 citations per article, indicating high scientifc impact. Collaborative research is prevalent, with 13,598 authors averaging 7.21 co-authors per publication and over 21 % of research produced via international partnerships. Publication formats included journal articles, reviews, and conference papers. Keyword cooccurrence analysis revealed fve main thematic clusters: computational and omics methodologies; tumor biology and immunology; molecular mechanisms and cancer progression; biomarkers and gene regulation; and interdisciplinary cancer research. Publication patterns indicated steady output before 2013 followed by a marked surge peaking near 500 articles in 2023, driven by advancements in genomics, big data analytics, and precision oncology. Citation data highlighted the United States and China as leading contributors, with China leading in publication count through predominantly domestic research, while the United States featured more international collaborations. Other signifcant contributors included Australia, Germany, Canada, and several European and Asian countries.
Conclusion. Research at the intersection of prostate cancer and bioinformatics is rapidly expanding, highly collaborative, and globally distributed. The multidisciplinary and integrative nature of this feld continues to advance understanding, diagnosis, and treatment of prostate cancer through cutting-edge bioinformatics approaches.

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