CLINICO-PATHOMORPHOLOGICAL STUDY OF MYELOFIBROSIS IN MULTIPLE MYELOMA
Abstract
Pathomorphology study of bone marrow fibrosis in patients with multiple myeloma by using morphometric image analysis software was performed. It was revealed that bone marrow fibrosis occurs 1.5 times more frequently in relapse of disease than in the initial presentation of the disease and in response to chemotherapy. The highest relative area of fibrous tissue in marrow fibrosis of 2nd and 3rd grade is observed in relapsed multiple myeloma. There is a direct correlation between the relative area of the tumor tissue in the bone marrow and the relative area of fibrous tissue in bone marrow fibrosis of the 1st and the 2nd grade. Chemotherapy is a factor associated with bone marrow fibrosis of the 2nd and the 3rd grade. Gender and age of the patients are not associated with marrow fibrosis.
About the Authors
Yu. A. Dyachkova
Research Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk 2
Russian Federation
Timakova Street, 630117-Novosibirsk, 2
Russian Federation
Timakova Street, 630117-Novosibirsk, 2
T. Yu. Dolgikh
Research Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk 2
Russian Federation
Russian Federation
N. P. Domnikova
Research Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk 2
Russian Federation
Russian Federation
References
1. Russian Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative diseases / Ed. I.V. Poddubnaya, V.G. Savchenko. М.: Media Medika, 2013. 104 p. [in Russian]
2. Abildgaard N., Bendix-Hansen K., Kristensen J.E., Vejlgaard T., Risteli L., Nielsen J.L., Heickendorff L. Bone marrow fibrosis and disease activity in multiple myeloma monitored by the aminoterminal propeptide of procollagen III in serum // Br. J. Haematol. 1997. Vol. 99 (3). P. 641–648.
3. Babarović E., Valković T., Štifter S., Budisavljević I., Seili-Bekafigo I., Duletić-Načinović A., Lučin K., Jonjić N. Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma // Am. J. Clin. Pathol. 2012. 137 (6): 870–8. doi: 10.1309/AJCPT5Y2JRIUUCUB.
4. Bladé J., Samson D., Reece D., Apperley J., Björkstrand B., Gahrton G., Gertz M., Giralt S., Jagannath S., Vesole D. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant // Br. J. Haematol. 1998. Vol. 102 (5). P. 1115–1123.
5. Chen H.S., Liu E.B., Wang T.T., Yang R.C., Fang L.H., Yang Q.Y., Gao J.Y., Yu M.H., Qian L.S. Morphologic and clinical study of 131 cases of plasma cell myeloma // Zhonghua Bing Li Xue Za Zhi. 2004. Vol. 33 (1). P. 44–48.
6. Durie B.G., Salmon S.E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival // Cancer. 1975. Vol. 36 (3). P. 842–854.
7. Huang Y.W., Hamilton A., Arnuk O.J., Chaftari P., Chemaly R. Current drug therapy for multiple myeloma // Drugs. 1999. Vol. 57 (4). P. 485–506.
8. Kyle R.A., Rajkumar S.V. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma // Leukemia. 2009. № 23. P. 3–9. doi: 10.1038/leu.2008.291.
9. Singhal N., Singh T., Singh Z.N., Shome D.K., Gaiha M. Histomorphology of multiple myeloma on bone marrow biopsy // Indian J. Pathol. Microbiol. 2004. Vol. 47 (3). P. 359–363.
10. Subramanian R., Basu D., Dutta TK. Significance of bone marrow fibrosis in multiple myeloma // Pathology. 2007. Vol. 39 (5). P. 512–515.
11. Tadmor T., Shvidel L., Aviv A., Ruchlemer R., Bairey O., Yuklea M., Herishanu Y., Braester A., Rahimi-Levene N., Vernea F., Ben-Ezra J., Bejar J., Polliack A. Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis // Cancer. 2013. Vol. 119 (10). P. 1853–1859. doi: 10.1002/cncr.27930.
12. Thiele J., Kvasnicka H.M., Facchetti F., Franco V., van der Walt J., Orazi A. European consensus on grading bone marrow fibrosis and assessment of cellularity // Haematologica. 2005. Vol. 90. P. 1128–1132.
Review
For citations:
Dyachkova Yu.A., Dolgikh T.Yu., Domnikova N.P. CLINICO-PATHOMORPHOLOGICAL STUDY OF MYELOFIBROSIS IN MULTIPLE MYELOMA. Siberian journal of oncology. 2014;(3):34-38. (In Russ.)
Views:
533
Email this article 
